Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease

Abstract

Objective: to study the effect of polyphenolic antioxidants, resveratrol and quercetin, on endothelial degeneration factors in cad patients. Materials and Methods: the study involved 93 patients with coronary artery disease: stable angina pectoris, fc ii. the cytofluorometric technique was applied to define the level of circulating endothelial microparticles (emP) cd32+cd40+ in peripheral blood in order to identify ed. the content of tumor necrosis factor α (tnf-α), fibrinogen, hemocoagulation and lipid profile parameters were being determined in the blood, as well. Patients were divided into 3 groups. basic therapy (β-blockers, statins, aspirin) was prescribed to 33 persons of the comparison group, patients of the study group 1 (30 persons) additionally received resveratrol at a dose of 100 mg daily, patients of the study group 2 (30 persons) got quercetin at a dose of 3 g per day. in 2 months, the second examination of the patients was performed in the amount indicated. Results: under the influence of resveratrol a significant reduction of the level of tnf-α and the number of emP in peripheral blood was shown, in contrast to the results of other study groups. all groups showed a decrease in total cholesterol and low-density lipoprotein cholesterol, statistical differences between data of groups were not found. indicators of coagulogramma in all study groups did not change significantly, however, there was a statistically significant reduction of fibrinogen in the blood. Conclusions: resveratrol, unlike quercetin, has a positive effect on the endothelial function and systemic inflammation, which may be the result of its influence on intracellular molecular cascades associated with the nuclear transcription factor of nf-kb.