Please use this identifier to cite or link to this item:
Title: Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease
Authors: Chekalina, N.
Kazakov, Yu.
Mamontova, T.
Vesnina, L.
Kaidashev, I. P.
Кайдашев, Ігор Петрович
Чекаліна, Наталія Ігорівна
Казаков, Юрій Михайлович
Мамонтова, Тетяна Василівна
Весніна, Людмила Едуардівна
Issue Date: 2016
Publisher: Czasopismo Polskiego Towarzystwa Lekarskiego Wiadomości Lekarskie
Citation: Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease / N. I. Chekalina, Yu. M. Kazakov, T. V. Mamontova [et al.] // Wiadomosci Lekarskie. – 2016. – Vol. 69, № 3 (cz II). – P. 479–483.
Abstract: Objective: to study the effect of polyphenolic antioxidants, resveratrol and quercetin, on endothelial degeneration factors in cad patients. Materials and Methods: the study involved 93 patients with coronary artery disease: stable angina pectoris, fc ii. the cytofluorometric technique was applied to define the level of circulating endothelial microparticles (emP) cd32+cd40+ in peripheral blood in order to identify ed. the content of tumor necrosis factor α (tnf-α), fibrinogen, hemocoagulation and lipid profile parameters were being determined in the blood, as well. Patients were divided into 3 groups. basic therapy (β-blockers, statins, aspirin) was prescribed to 33 persons of the comparison group, patients of the study group 1 (30 persons) additionally received resveratrol at a dose of 100 mg daily, patients of the study group 2 (30 persons) got quercetin at a dose of 3 g per day. in 2 months, the second examination of the patients was performed in the amount indicated. Results: under the influence of resveratrol a significant reduction of the level of tnf-α and the number of emP in peripheral blood was shown, in contrast to the results of other study groups. all groups showed a decrease in total cholesterol and low-density lipoprotein cholesterol, statistical differences between data of groups were not found. indicators of coagulogramma in all study groups did not change significantly, however, there was a statistically significant reduction of fibrinogen in the blood. Conclusions: resveratrol, unlike quercetin, has a positive effect on the endothelial function and systemic inflammation, which may be the result of its influence on intracellular molecular cascades associated with the nuclear transcription factor of nf-kb.
Keywords: coronary artery disease
endothelial dysfunction
circulating endothelial microparticles
ISSN: 0043-5147
Appears in Collections:Наукові праці. Кафедра пропедевтики внутрішньої медицини

Files in This Item:
File Description SizeFormat 
Resveratrol.pdf244,86 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.