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http://repository.pdmu.edu.ua/handle/123456789/1038
Повний запис метаданих
Поле DC | Значення | Мова |
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dc.contributor.author | Chekalina, N. | - |
dc.contributor.author | Kazakov, Yu. | - |
dc.contributor.author | Mamontova, T. | - |
dc.contributor.author | Vesnina, L. | - |
dc.contributor.author | Kaidashev, I. P. | - |
dc.contributor.author | Кайдашев, Ігор Петрович | - |
dc.contributor.author | Чекаліна, Наталія Ігорівна | - |
dc.contributor.author | Казаков, Юрій Михайлович | - |
dc.contributor.author | Мамонтова, Тетяна Василівна | - |
dc.contributor.author | Весніна, Людмила Едуардівна | - |
dc.date.accessioned | 2017-10-13T06:33:15Z | - |
dc.date.available | 2017-10-13T06:33:15Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease / N. I. Chekalina, Yu. M. Kazakov, T. V. Mamontova [et al.] // Wiadomosci Lekarskie. – 2016. – Vol. 69, № 3 (cz II). – P. 479–483. | uk_UA |
dc.identifier.issn | 0043-5147 | - |
dc.identifier.uri | http://repository.pdmu.edu.ua/handle/123456789/1038 | - |
dc.description.abstract | Objective: to study the effect of polyphenolic antioxidants, resveratrol and quercetin, on endothelial degeneration factors in cad patients. Materials and Methods: the study involved 93 patients with coronary artery disease: stable angina pectoris, fc ii. the cytofluorometric technique was applied to define the level of circulating endothelial microparticles (emP) cd32+cd40+ in peripheral blood in order to identify ed. the content of tumor necrosis factor α (tnf-α), fibrinogen, hemocoagulation and lipid profile parameters were being determined in the blood, as well. Patients were divided into 3 groups. basic therapy (β-blockers, statins, aspirin) was prescribed to 33 persons of the comparison group, patients of the study group 1 (30 persons) additionally received resveratrol at a dose of 100 mg daily, patients of the study group 2 (30 persons) got quercetin at a dose of 3 g per day. in 2 months, the second examination of the patients was performed in the amount indicated. Results: under the influence of resveratrol a significant reduction of the level of tnf-α and the number of emP in peripheral blood was shown, in contrast to the results of other study groups. all groups showed a decrease in total cholesterol and low-density lipoprotein cholesterol, statistical differences between data of groups were not found. indicators of coagulogramma in all study groups did not change significantly, however, there was a statistically significant reduction of fibrinogen in the blood. Conclusions: resveratrol, unlike quercetin, has a positive effect on the endothelial function and systemic inflammation, which may be the result of its influence on intracellular molecular cascades associated with the nuclear transcription factor of nf-kb. | uk_UA |
dc.language.iso | en | uk_UA |
dc.publisher | Czasopismo Polskiego Towarzystwa Lekarskiego Wiadomości Lekarskie | uk_UA |
dc.subject | coronary artery disease | uk_UA |
dc.subject | endothelial dysfunction | uk_UA |
dc.subject | resveratrol | uk_UA |
dc.subject | quercetin | uk_UA |
dc.subject | circulating endothelial microparticles | uk_UA |
dc.title | Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease | uk_UA |
dc.type | Article | uk_UA |
Розташовується у зібраннях: | Наукові праці. Кафедра пропедевтики внутрішньої медицини |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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Resveratrol.pdf | 244,86 kB | Adobe PDF | Переглянути/Відкрити |
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