Патофізіологічні та морфологічні особливості змін в адренокортикоцитах пучкової зони наднирників за умов дії червоного шламу

Abstract

В дослідженні отримані нові дані відносно характеру і динаміки патофізіологічних та морфологічних змін в адренокортикоцитах пучкової зони кори надниркових залоз за умов тривалої дії на організм червоного шламу. Встановлена залежність змін структури і функції клітин пучкової зони кори наднирників від тривалості дії червоного шламу у тварин різного віку; В исследовании получены новые данные относительно характера и динамики патофизиологических и морфологических изменений в адренокортикоцитах пучковой зоны коры надпочечниковых желез в условиях длительного действия на организм красного шлама. Установлена зависимость изменений структуры и функции клеток пучковой зоны надпочечников от длительности действия красного шлама у животных различного возраста; By means of modern techniques, new data, regarding the character and dynamics of structural and functional changes in adrenal cortical cells under condition of prolonged organism exposure of the red mud, has been obtained. Purpose. To evaluate the dynamics of the structural and functional changes and the direction of reparative processes in adrenal cortical cells of animals of all ages under organism exposure of the red mud. Methods. In the adrenal glands of control and experimental animals was measured in the cortex generally accepted methodology calculated the average volume of the cells, their nuclei and nucleoli. Studying the dynamics of changes in the number of adrenocorticocytes with dark or light and using kits of reagent «steroidIFA-cortisol» determined the concentration of cortisol in peripheral blood of animal. Results. The article investigates the structural changes of zona fasciculata adrenal cortical cells under the prolonged exposure of the red mud. It was established that the red mud exposure on the rats for 14 days causes increased adrenocortical functional, which was accompanied by corresponding changes in the structure of these cells and the morphometric data. The red mud exposure on 45-day-old rats reduces adrenocortical function and causes significant dystrophic and degenerative rearrangement in these cells. On the 180th day of the experiment adrenocorticocytes reduction function is accompanied by structural changes that are characteristic of the depletion stage of general adaptation syndrome. Originality. Using modern biomedical research methods, new data regarding the character and dynamics of structural changes in adrenal cortical cells under the prolonged exposure of the red mud, has been obtained. The dependence of changes of the structure and the function of adrenal cortical cells on the duration of the red mud exposure in animals’ organisms of all ages has been established. Conclusion. The prolonged exposure of the red mud on animals’ organisms leads to significant changes in the structural organization in adrenal cortical cells, the character of which depends on both the duration of the red mud exposure as well as on the animals’ age.