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Повний запис метаданих
Поле DC | Значення | Мова |
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dc.contributor.author | Pryimenko, N. O. | - |
dc.contributor.author | Kotelevska, T. M. | - |
dc.contributor.author | Koval, T. I. | - |
dc.contributor.author | Syzova, L. M. | - |
dc.contributor.author | Dubynska, H. M. | - |
dc.contributor.author | Kaidashev, I. P. | - |
dc.contributor.author | Прийменко, Наталія Олегівна | - |
dc.contributor.author | Котелевська, Тетяна Михайлівна | - |
dc.contributor.author | Коваль, Тетяна Ігорівна | - |
dc.contributor.author | Сизова, Людмила Михайлівна | - |
dc.contributor.author | Дубинська, Галина Михайлівна | - |
dc.contributor.author | Кайдашев, Ігор Петрович | - |
dc.date.accessioned | 2020-02-03T09:32:11Z | - |
dc.date.available | 2020-02-03T09:32:11Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Genetic polymorphism Arg753Gln of TLR-2, Leu412Phe of TLR-3, Asp299Gly of TLR-4 in patients with influenza and influenza-associated pneumonia / N. O. Pryimenko, T. M. Kotelevska, T. I. Koval [et al.] // Wiadomosci lekarskie. – 2019. – Т. LXXII, Nr. 12 (1) − P. 2324−2328. | uk_UA |
dc.identifier.uri | http://repository.pdmu.edu.ua/handle/123456789/11787 | - |
dc.description.abstract | The aim of the research is to study the prevalence and to determine the prognostic significance of polymorphism ARG753GLN of the TLR-2 gene, Leu412Phe of TLR-3, Asp299Gly of TLR-4 in influenza. Materials and methods: 112 patients with influenza were examined (63 patients with uncomplicated course and 49 with influenza-associated pneumonia). The genotyping of the polymorphic site of ARG753GLN of the TLR-2 gene, Asp299Gly of the TLR-4 gene, and Leu412Phe of the TLR-3 gene was carried out by polymerase chain reaction using oligonucleotide primers. Results: It has found that the prevalence of the mutant allele 299Gly of TLR-4 in patients with uncomplicated influenza is 6.4 %, with influenza- associated pneumonia – 7.1 %, which exceeds the population control indicators by 3.8-4.3 times (1.7 %, p<0.05). Mutant allele 412Phe of TLR-3 is significantly more common in patients with influenzaassociated pneumonia (42.9%), as compared with uncomplicated influenza (24.6%, p<0.01) and healthy people (30.0%, p<0.05). The increased risk of influenza development is associated with the Asp/Gly genotype of TLR-4 (OR=4.22) and combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2 (OR=15.0); influenza-associated pneumonia − with genotype Phe/Phe of TLR-3 (OR=4.5). Conclusions: It has been found out that among patients with influenza and influenza-associated pneumonia, the mutant allele 299Gly of TLR-4 and combinations of polymorphisms Arg753Gln of TLR-2, Leu412Phe of TLR-3, Asp299Gly of TLR-4 are detected reliably more often. The frequency of the mutant allele 412Phe of TLR-3 is higher among patients with influenza-associated pneumonia. Markers of increased risk of influenza are 299Gly allele and genotype Asp/Gly of TLR-4 and the combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2; for influenza-associated pneumonia − allele 412Phe and genotype Phe/Phe of TLR-3. | uk_UA |
dc.language.iso | en | uk_UA |
dc.publisher | Aluna Publishing | uk_UA |
dc.subject | influenza | uk_UA |
dc.subject | influenza-associated pneumonia | uk_UA |
dc.subject | Arg753Gln polymorphism of the TLR-2 gene | uk_UA |
dc.subject | Asp299Gly polymorphism of the TLR-4 gene | uk_UA |
dc.subject | Leu412Phe polymorphism of the TLR-3 gene | uk_UA |
dc.subject | genotype | uk_UA |
dc.subject | allele | uk_UA |
dc.title | Genetic polymorphism Arg753Gln of TLR-2, Leu412Phe of TLR-3, Asp299Gly of TLR-4 in patients with influenza and influenza-associated pneumonia | uk_UA |
dc.type | Article | uk_UA |
dc.identifier.doi | 10.36740/WLek201912110 | - |
Розташовується у зібраннях: | Наукові праці. Кафедра інфекційних хвороб з епідеміологією |
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