Single nucleotide polymorphism of -174G/C interleukin-6 gene in patients of different weight categories with non-lacunar strokes and its associations with clinical and functional stroke outcomes

Abstract

We studied the single nucleotid polymorphisms (SNP) distribution of -174 G/C interleukin-6 gene (IL-6) and determined its associations with functional outcomes after non-lacunar stroke in 33 patients with normal body weight and in 37 patients with abdominal obesity (AO) II class. The study has involved patients of similar age (56 to 65 years), with the similar clinical disease severity on admission (5-10 points according to NIHS scale), with relatively similar cerebral lesion volumes (from 10 to 20 cm3 ), without diabetes mellitus and severe co-morbidity. Abdominally obese patients II class with non-lacunar strokes have significantly more common 174 C allele of the IL-6 gene compared with patients with normal body weight (65% versus 45%, p<0,05). In patients with normal body weight G/G genotype of -174 G/C gene IL-6 was significantly associated with more severe acute stroke an increased rate of late "disabling" functional states (values of modified Rankin scale more then 2 points) in 12 weeks after stroke. AO II class hasn’t any patterns of clinical and functional outcomes distribution depending on SNP -174 G/C gene IL-6.