Изучение механизмов расширения спектра цитотоксичности пегилированных липосомальных систем доставки противоопухолевых препаратов методом спиновых зондов
Ескіз недоступний
Дата
2019
Назва журналу
Номер ISSN
Назва тому
Видавець
RS Global Sp. z O.O.,Warsaw, Poland
Анотація
Pegylated liposomal anticancer drugs, in particular, doxorubicin havean expansion of the spectrum of toxicity. To study the mechanisms of influence of polyethylene glycol (PEG) on the structure of cell membranes, the sensitive biophysical method of spin probes was used. Using the spin probe method, it has been shown that in the presence of an increased prothrombin blood index, increased blood viscosity and a high density of red blood cells and other blood components, large and long fragments of PEG molecules located on the surface of pegylated liposomal delivery systems caneffectively interact with the membranes of neighboring cells. The list of even these possible effects, which were determined and described by us in experiments for bovine serum albumin, liposomes, erythrocytes and skin tissue, suggests that the expansion of the spectrum of the specific toxicity of pegylated liposomes may be directly or indirectly associated with the mechanisms of action of PEG on proteins and cell membranes.
Опис
Ключові слова
cytotoxicity, pegylated liposomal delivery systems, microviscosity of membrane lipids, spin probe method, hydrophobic interaction
Бібліографічний опис
Изучение механизмов расширения спектра цитотоксичности пегилированных липосомальных систем доставки противоопухолевых препаратов методом спиновых зондов / Л. В. Иванов, А. В. Щербак, В. Г. Кравченко, Л. В. Деримедведь, Э. В. Супрун // World Scince. – 2019. – Vol. 3, № 6 (46). – P. 26–36.