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Title: Application efficiency of bifidobacterium bifidum 1 and lactobacillus reuteri dsm 17938 cell-free extracts in vivo
Authors: Книш, Оксана Василівна
Погоріла, Марина Сергіївна
Полянська, Валентина Павлівна
Зачепило, Світлана Вікторівна
Knysh, O.
Pogorila, M.
Polianska, V.
Zachepylo, S.
Issue Date: 2020
Citation: Knysh O. Application efficiency of BifIdobacterium BifIdum 1 and Lactobacillus reuteri DSM 17938 cell-free extracts in vivo / O. Knysh, M. Pogorila, V. Polianska, S. Zachepylo // Science Review. – 2020. – № 5 (32). – P. 9–15.
Abstract: Insufficient efficiency and safety of cellular probiotics encourages the search for new effective means of correction of microecological disorders. Most of the beneficial effects of probiotics are due to the biological activity of their structural components and metabolites. Recently, great hope is pinned on postbiotic products as a means of restoring the balance of intestinal microbial populations. The data obtained in this experimental study demonstrate the ability of cell-free extracts from Bifidobacterium bifidum 1 and Lactobacillus reuteri DSM 17938 cultures, cultivated in their own disintegrates supplemented with ascorbic acid, to provide anti-infection protection and correct microecological disturbances at modeling an infectious process against a background of antibiotic-induced dysbiosis in mice. The beneficial effects of cell-free extracts showed up in the acceleration of the pathogen elimination and an increase in the number of representatives of the positive intestinal microbiota. The results of the study justify the need for further clinical trials to determine the therapeutic efficacy of cell-free extracts when included in the protocols of dysbiosis treatment.
Keywords: probiotic cell-free extracts,
Bifidobacterium bifidum 1
Lactobacillus reuteri DSM 17938
antibiotic-induced dysbiosis
murine model of intestinal staphylococcal infection
ISSN: 2544-9346
Appears in Collections:Наукові праці. Кафедра мікробіології, вірусології та імунології

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