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http://repository.pdmu.edu.ua/handle/123456789/15807| Title: | Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes |
| Authors: | Savchenko, L. G. Digtiar, N. I. Selіkhova, l. G. Kaidasheva, E. I. Shlykova, O. A. Vesnina, l. E. Kaidashev, I. P. Савченко, Людмила Гаврилівна Дігтяр, Наталія Іванівна Селіхова, Людмила Григорівна Кайдашева, Єльвіра Іллівна Шликова, Оксана Анатоліївна Весніна, Людмила Едуардівна Кайдашев, Ігор Петрович |
| Issue Date: | 2019 |
| Citation: | Liraglutide exerts an anti-inflammatory action in obese patients with type 2 diabetes / L. G. Savchenko, N. I. Digtiar, l. G. Selikhova [et al.] // ROM. J. INTERN. MED. – 2019. –T. 57, № 3. – P. 233–240. |
| Abstract: | Liraglutide (L) is the analogue of human glucagon-like peptide 1 which stimulates glucose-dependent insulin secretion and can modify the level of inflammatory biomarkers. L can influence NF-kB inflammatory cascade, but the mechanisms of anti-inflammatory activities of L remain to be determined. In animal models L influenced an activity of Sirtuin l(SIRTl). Moreover, recent evidences strongly suggest that SIRT1 up-regulation may serve as a potent therapeutic approach against development and progression of diabetic complications. The aim of this study was to investigate L effects directed on the pro-inflammatory NF-kB pathway and expression of SIRT1 in obese patients with type 2 diabetes mellitus (DM). |
| Keywords: | glucagon-like peptide 1 (GLP-1) liraglutide; diabetes obesity NF-kB SIRT1 mediators of inflammation |
| URI: | http://repository.pdmu.edu.ua/handle/123456789/15807 |
| Appears in Collections: | Наукові праці. Кафедра фізіології |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Liraglutide.pdf | 6,13 MB | Adobe PDF | View/Open |
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