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Повний запис метаданих
Поле DC | Значення | Мова |
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dc.contributor.author | Zaporozhets, T. | - |
dc.contributor.author | Sanyk, O. | - |
dc.contributor.author | Запорожец, Татьяна Николаевна | - |
dc.contributor.author | Саник, Александр Владимирович | - |
dc.contributor.author | Запорожець, Тетяна Миколаївна | - |
dc.contributor.author | Саник, Олександр Володимирович | - |
dc.date.accessioned | 2017-10-24T15:13:13Z | - |
dc.date.available | 2017-10-24T15:13:13Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | Zaporozhets T. Bone marrow cells apoptosis in experimental anemia / T. Zaporozhets, O. Sanyk // Faseb J. – 2014. – Vol. 28. – P. 1093–1094. | uk_UA |
dc.identifier.uri | http://repository.pdmu.edu.ua/handle/123456789/1640 | - |
dc.description.abstract | Environmental pollution consisting of toxic metals and ionizing radiation is a serious problem throughout the world. Our objective was to compare the level of markers (BCL- 2 and p53) of the bone marrow cells apoptosis in experimental gamma- irradiation and chronic lead intoxication. Methods: guinea pigs (n = 24) were divided into two groups. The first group of animals received a single dose of 4.5 Gr of gamma irradiation extracorporeal (aplastic anemia model). The second group received a 4% lead acetate solution for 60 mg/kg body weight per day for 27 days (anemia associated with violation of the synthesis of porphyrins). The level of Bcl- 2 and p53 was determined immunohistochemically. We observed:1) In the irradiated animals the number of cells with a marker protein Bcl- 2 was reduced to 45.23 % and the number of cells with p53 marker was increased to 112.8 % compared to control animals. 2) In animals with chronic lead intoxication the number of cells with a marker protein Bcl- 2 was decreased to 16.42 % and the number of cells with p53 marker was increased to 61.37 % compared to control animals. We conclude that apoptosis of bone marrow cells increases with aplastic anemia and anemia associated with violation of the synthesis of porfirins, which is a major pathogenetic mechanism of anemia. It may be one of the factors capable of causing deficiency of stem cells in this pathology. | uk_UA |
dc.language.iso | en_US | uk_UA |
dc.publisher | FASEB | uk_UA |
dc.relation.ispartofseries | J April 2014; | - |
dc.subject | bone marrow | uk_UA |
dc.subject | cells apoptosis | uk_UA |
dc.subject | костный мозг | uk_UA |
dc.subject | кістковий мозок | uk_UA |
dc.subject | апоптоз клеток | uk_UA |
dc.subject | клітинний апоптоз | uk_UA |
dc.title | Bone marrow cells apoptosis in experimental anemia | uk_UA |
dc.title.alternative | Апоптоз клітин кісткового мозку при експериментальній анемії | uk_UA |
dc.title.alternative | Апоптоз клеток костного мозга в экспериментальной анемии | uk_UA |
dc.type | Thesis | uk_UA |
Розташовується у зібраннях: | Наукові праці. Кафедра фізіології |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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EB 2014.pdf | T. Zaporozhets, O. Sanyk.Bone marrow cells apoptosis in experimental anemia | 83,08 kB | Adobe PDF | Переглянути/Відкрити |
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