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Title: | Pathogenetic role of macrophage colony-stimulating factor (csf-1) in predicting endometrioid disease |
Authors: | Orlova, Y. A. Hromova, A. M. Kaidashev, I. P. Shlykova, O. A. Izmailova, O. V. Martynenko, V. B. Орлова, Юлія Андріївна Громова, Антоніна Макарівна Кайдашев, Ігор Петрович Шликова, Оксана Анатоліївна Ізмайлова, Ольга Віталіївна Мартиненко, Віталій Борисович |
Issue Date: | Sep-2021 |
Publisher: | Aluna Publishing |
Citation: | Pathogenetic role of macrophage colony-stimulating factor (csf-1) in predicting endometrioid disease / Y. A. Orlova, A. M. Hromova, I. P. Kaidashev [et al.] // Wiadomości Lekarskie. – 2021. – Vol. LXXIV, issue 8. – P. 1939–1944. |
Abstract: | The aim: To assess the CSF – 1 level in peritoneal fluid and menstrual blood of women with endometrioid disease and to investigate its diagnostic and prognostic specificity. Materials and methods: The study included 80 women of child-bearing age (mean age 30.95 ± 6.49 years) with benign gynaecological pathology of the ovaries and / or fallopian tubes. The women included in the study were divided into two groups: study group (n = 50, mean age 31.04 ± 6.3 years), consisting of patients with confirmed endometrioid disease, and control group (n = 30, mean age 30.8 ± 6.8 years), involving individuals without signs of endometriosis (p> 0.05). Results: We have found significantly higher level of CSF-1 content in the peritoneal fluid in the subjects of the study group (2027.05 ± 732.64 pg / ml) compared with those in the control group (1725.62 ± 466.06 pg / ml) (p = 0.029). There is a tendency towards an increase in CSF-1 level in women with endometriosis in its more severe stages and more severe and extended adhesions. The investigation of CSF-1 content in menstrual blood has demonstrated significant increase in its values in the women of the study group (9431.6 ± 2866.22 pg / ml) compared with the values in the control group (6637.12 ± 954.05 pg / ml), (p = 0.00004). Thus, there is a tendency towards the growth in CSF-1 level in peritoneal fluid and menstrual blood in women with endometriosis and concurrent increase in severity of the disease. Conclusions: There has been found significant increase in CSF-1 content in women with endometrioid disease in both peritoneal fluid and menstrual blood (1.2 and 1.4 times, respectively). Thus, macrophage growth factor (CSF-1) can be used as a diagnostic and prognostic criterion in evaluating the progression of endomertioid disease |
Keywords: | endometriosis peritoneal fluid menstrual blood |
ISSN: | 0043-5147 |
DOI: | 10.36740/WLek202108128 |
URI: | http://repository.pdmu.edu.ua/handle/123456789/17422 |
Appears in Collections: | Наукові праці. Кафедра акушерства і гінекології № 1 |
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