Please use this identifier to cite or link to this item: http://repository.pdmu.edu.ua/handle/123456789/18019
Title: Dynamics of changes of c-reactive protein level in blood serum in the development and course of experimental periodontitis and their correction by flavonol
Authors: Demkovych, Andrii
Hasiuk, Petro
Korobeinikova, Yuliia
Shcherba, Vitaliy
Korobeinikov, Leonid
Демкович, Андрій Євгенович
Гасюк, Петро Анатолійович
Коробейнікова, Юлія Леонідівна
Щерба, Віталій Володимирович
Коробейніков, Леонід Сергійович
Issue Date: Feb-2022
Publisher: Aluna Publishing
Citation: Dynamics of changes of c-reactive protein level in blood serum in the development and course of experimental periodontitis and their correction by flavonol / A. Demkovych, P. Hasiuk, Y. Korobeinikova [et al.] // Wiadomości Lekarskie. – 2022. – Vol. LXXV, issue 2. – P. 451–455.
Abstract: The aim: To study the value of C-reactive protein in the experimental animals blood serum with bacterial-immune periodontitis and its correction with quercetin. Materials and methods: Modeling of periodontitis was performed by the following method: after thiopental anesthesia (at a dose of 40 mg / kg intramuscularly) rats were fixed. A subcostal injection of 0.01 ml of egg protein with cultures of Streptococcus hemolytic and Staphylococcus aureus at a dose of 4 CFU was performed in the area of periodontal tissues of the lower incisor as an initiating inflammatory factor. To enhance the immune process, a complete Freund’s adjuvant was introduced into the animal’s hind limb at the same time. Results: Analysis of the results of the study of the content of C-reactive protein in the blood serum of animals with experimental bacteria and immune periodontitis, receiving injections of quercetin, showed a significant decrease by 1.31 times, compared with animals with this simulated pathology on the 14th day of the experiment without the use of flavonol. When comparing this indicator on the 14th day of development of experimental periodontitis with correction, it was found that it remained slightly higher than the indicators of the intact group of rats. Conclusions: The level of C-reactive protein in the blood serum of experimental animals is an important indicator of the immune-inflammatory response, which increases its activation of the inflammatory system. The administration of flavonoid quercetin for 7 days helps to reduce the level of C-reactive protein in the blood serum of animals with experimental bacterial and immune periodontitis.
Keywords: protein level
blood serum
experimental periodontitis
flavonol
DOI: 10.36740/WLek202202122
URI: http://repository.pdmu.edu.ua/handle/123456789/18019
Appears in Collections:Наукові праці

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