Please use this identifier to cite or link to this item: http://repository.pdmu.edu.ua/handle/123456789/18198
Title: Host gene variability and SARS-CoV-2 infection: A review articleI.
Authors: Kaidashev, I.
Shlykova, O.
Izmailova, O.
Torubarа, O.
Yushchenko, Ya.
Tyshkovska, T.
Kyslyi, V.
Belyaeva, A.
Maryniak, D.
Кайдашев, Ігор Петрович
Шликова, Оксана Анатоліївна
Ізмайлова, Ольга Віталіївна
Торубара, Олександра Олексіївна
Ющенко, Яна Олександрівна
Кислий, Владислав Федорович
Мариняк, Дар'я Костянтинівна
Беляєва, Антоніна Олександрівна
Issue Date: 2021
Citation: Host gene variability and SARS-CoV-2 infection: A review article / I. Kaidashev, O. Shlykova, O. Izmailova [et al.] // Heliyon, 2021. – Vol. 7, issue 8. – e 07863.
Abstract: SARS-CoV-2 is a global threat that influenced healthcare systems around the world. This virus caused an infection in humans with different clinical signs and syndromes, severity, and mortality. The key components of the COVID-19 molecular pathogenesis are coronavirus entry and replication, antigen presentation, humoral and cellular immunity, cytokine storm, coronavirus immune evasion. The analysis of recent literature displayed possible molecular targets in the key components of the COVID-19 pathogenesis. Some of these targets might have gene polymorphisms that influenced the COVID-19 course. Un- fortunately, several findings are still putative or extrapolated from SARS and MERS experimental investigations orclinical trials. We systematised original data about gene polymorphisms of possible molecular targets and associations with the COVID-19 course. Most data were obtained for angiotensin-converting enzymes 1 and 2, TMPRSS2 gene polymorphisms. Only a few results were found for gene polymorphisms of adhesion molecules, interferon system components, cytokines, and transcriptional factors, oxidative stress and metabolic molecules, as well as haemocoagulation. Understanding the host gene variability and its associations with COVID-19 can provide insights into the disease pathogenesis, individual susceptibility to SARS-CoV-2 infection, severity, complications, and mortality prognosis for the disease. Besides, these data might help in the identification of appropriate targets for intervention.
Keywords: gene
polymorphism
Infection
SARS-CoV-2
COVID-19
pathogenesis
URI: http://repository.pdmu.edu.ua/handle/123456789/18198
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