Natural peptide complexes of thymus and kidneys reinforce apoptosis of transformed T-cells, but do not affect the processes of apoptosis in B-cells

Abstract

One of the most important issues in modern medicine is the search for methods for regulating programmed cell death in order to develop new approaches to treatment, including cancer and leukemia. Humoral regulation of theprocesses of apoptosis with the help of cytokines, hormones, growth factors, peptides plays an important role in the mechanisms of regulation of apoptosis. The effect of natural peptide complexes of thymus and kidneys on HPB-ALL (acute T-cell leukemia) and BJAB (Berkita lymphoma) cell apoptosis processes has been studied. It has been shown that the natural peptide complexes of the thymus and the kidneys have little stimulating effect on the apoptosis of BJAB tumor B cells at low concentrations, and when increasing the dose of peptides, they do not affect the processes of apoptosis; it is believed that the processes of elimination of transformed T-cells are enhanced by activating apoptosis processes in them. With the action of the natural peptide complex of thymus, this effect has a dose-dependent nature - increases with raising the dose.