The role of genes polymorphism of Toll- like receptors 2,4 and clara cell protein in the development of asthma in adults

Abstract

Genetic aspects of asthma and atopy have been widely studied. Candidate genes and loci of chromosomes probably responsible for the occurrence of bronchial asthma (BA) is defined by a large amount. The aim of our work was to study polymorphisms 2258G / A gene TLR2 (rs5743708) and 896A / G genaTLR4 (rs4986791), Clara cell protein gene (A38G), with a specific weight of 16 kDa (CC16) in the adult population. Materials and Methods. We examined 45 patients with asthma in the period without exacerbation. Diagnosis of asthma severity and installed in accordance with the approved criteria. Results: Рatients with BA significantly more common had genotype GA (11,1%) gene TLR2 (p = 0.04) compared with the control group. In patients who are carriers of a mutant allele of a gene TLR2 A history pneumonia frequently observed (p = 0.046) and there were signs of candidiasis (p = 0.034) compared with patients with no polymorphism. In the study of polymorphism of TLR 4 found that genotype AG statistically more likely (p = 0.04) is found in the BA group (15.6%) than in the control group. Patients with polymorphism 896A / G TLR4 gene disease begins in childhood (p = 0.03) in the spectrum of sensitization were dietary factors (p = 0.02) and there were other manifesta- tions of allergic diseases (p = 0.045). Polymorphic variant gene 38G CC16 significantly more common in patients with BA than in the control population (p = 0.019). Clinical manifestations in patients with ВA who are carriers of the gene allele 38G CC16 are fungal sensitization, atopic dermatitis and history of tuberculosis, the need for frequent doses of glucocor ticoids