The use of the domestic enzyme preparation Pancreatin 8000 in the rehabilitation of patients with chronic pancreatitis after surgery

Abstract

Aim: To investigate the clinical efficacy of the domestic enzyme drug Pancreatin 8000 in the rehabilitation of patients with chronic pancreatitis after operations on the pancreas. Materials and Methods: A study of 32 patients with chronic pancreatitis who received the drug Pancreatin 8000 (8000 lpolytic Ph. U., 5800 amylolytic Ph. U. and 380 proteolytic Ph. U.) The course of treatment was 21 days. In the course of the study we evaluated the growth rate index (calculated by the formula: В/P – 100, where В is weight in kilograms, Р is growth in centimeters) and data of clinical examinations. А pain syndrome was estimated by the nature, expressed and depending on a meal and daypart. Results: In average, normalization of the frequency of vomiting was noted on the 2nd - 8th day, on the 8th day, vomiting in all the patients was once a day and formalized. Pain decreased and disappeared in the period from the 2nd to the 7th day. In 3 (7%) patients the pain did not decrease, that is why it was necessary to use pain-relieving drugs. The dynamics of body weight increase was from 1 to 4 kg during 3 months of taking the drug in different patients. No increase in body weight was noted in 1 (2%) patients. The disappearance of symptoms of gastrointestinal and intestinal dyspepsia was noted on the 2nd to 6th day. Conclusions: Thus, the positive clinical effect of the drug Pancreatin 8000 is not only the result of the substituted enzyme therapy, but also the transition of the pancreas into a mode of functional calmness.