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http://repository.pdmu.edu.ua/handle/123456789/19970
Назва: | Porphyromonas gingivalis and non-alcoholic fatty liver disease as combined factors of periodontitis |
Автори: | Emelyanov, D. V. Petrushanko, T. О. Emelyanova, N. Yu. Ємельянов, Дмитро Вікторович Петрушанко, Тетяна Олексіївна Ємельянова, Наталія Юріївна |
Дата публікації: | 2022 |
Видавець: | Journal of the Italian Society of Orthopaedics and Medicine (OrtoMed). Publisher: Rome: Medimay. Country |
Бібліографічний опис: | Emelyanov D. V. Porphyromonas gingivalis and non-alcoholic fatty liver disease as combined factors of periodontitis / D. V. Emelyanov, T. О. Petrushanko, N. Yu. Emelyanova // International journal of bone fragility. ‒ 2022. ‒ № 2 (2). ‒ Р. 72‒76. |
Короткий огляд (реферат): | Purpose: This study is to determine the quantitative level of Porphyromonas gingivalis (P. gingivalis) in the periodontal pocket and its gingipain virulence factor in patients with non-alcoholic fatty liver disease (NAFLD). Methods: Dental status, composition of P. gingivalis, and levels of gingipain and blood endotoxin were studied in patients with NAFLD and in a control group. The quantitative composition of P. gingivalis was determined by the real-time quantitative polymerase chain reaction method (qRT-PCR). Gingipain K concentration in oral fluid was determined by an immunoenzymatic method. Results: The level of individual oral hygiene in the NAFLD patients was found to be unsatisfactory. Structurally, periodontal pathology was represented mainly by chronic grade B periodontitis. When analysing the correlation interaction, a positive dynamic was found between P. gingivalis and the presence of generalized periodontitis (GP) (r=0.652; p=0.000) and between gingipain and GP (r=0.510; p=0.006). The endotoxemia value correlated positively with the quantitative index of P. gingivalis (r=0.695; p=0.004), which is explained by the fact that periodontopathogen endotoxin (LPS), when entering the vascular bed, increases the systemic endotoxin level in general. Inflammation-causing cytokines and LPS in NAFLD contribute to the formation of an anaerobic environment in the periodontium that favours the quantitative growth of P. gingivalis. Conclusion: The highest levels of P. gingivalis and gingipain were recorded in patients with NAFLD, which is consistent with a background of decreased periodontal adaptive capabilities. The P. gingivalis/gingipain correlation ratio can allow the dentist to monitor the treatment of periodontal patients. |
Ключові слова: | periodontitis chronic inflammation gingipain periodontopathogen |
ISSN: | 2724-4296 (Online) |
DOI: | https:doi.org/10.57582/IJBF.220202.072 |
URI: | http://repository.pdmu.edu.ua/handle/123456789/19970 |
Розташовується у зібраннях: | Наукові праці. Кафедра терапевтичної стоматології |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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Porphyromonas_gingivalis_and_non_alcoholic_fatty_liver_disease.pdf | 395,96 kB | Adobe PDF | Переглянути/Відкрити |
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