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Повний запис метаданих
Поле DC | Значення | Мова |
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dc.contributor.author | Emelyanov, D. V. | - |
dc.contributor.author | Petrushanko, T. О. | - |
dc.contributor.author | Emelyanova, N. Yu. | - |
dc.contributor.author | Ємельянов, Дмитро Вікторович | - |
dc.contributor.author | Петрушанко, Тетяна Олексіївна | - |
dc.contributor.author | Ємельянова, Наталія Юріївна | - |
dc.date.accessioned | 2023-02-07T13:09:51Z | - |
dc.date.available | 2023-02-07T13:09:51Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Emelyanov D. V. Porphyromonas gingivalis and non-alcoholic fatty liver disease as combined factors of periodontitis / D. V. Emelyanov, T. О. Petrushanko, N. Yu. Emelyanova // International journal of bone fragility. ‒ 2022. ‒ № 2 (2). ‒ Р. 72‒76. | uk_UA |
dc.identifier.issn | 2724-4296 (Online) | - |
dc.identifier.uri | http://repository.pdmu.edu.ua/handle/123456789/19970 | - |
dc.description.abstract | Purpose: This study is to determine the quantitative level of Porphyromonas gingivalis (P. gingivalis) in the periodontal pocket and its gingipain virulence factor in patients with non-alcoholic fatty liver disease (NAFLD). Methods: Dental status, composition of P. gingivalis, and levels of gingipain and blood endotoxin were studied in patients with NAFLD and in a control group. The quantitative composition of P. gingivalis was determined by the real-time quantitative polymerase chain reaction method (qRT-PCR). Gingipain K concentration in oral fluid was determined by an immunoenzymatic method. Results: The level of individual oral hygiene in the NAFLD patients was found to be unsatisfactory. Structurally, periodontal pathology was represented mainly by chronic grade B periodontitis. When analysing the correlation interaction, a positive dynamic was found between P. gingivalis and the presence of generalized periodontitis (GP) (r=0.652; p=0.000) and between gingipain and GP (r=0.510; p=0.006). The endotoxemia value correlated positively with the quantitative index of P. gingivalis (r=0.695; p=0.004), which is explained by the fact that periodontopathogen endotoxin (LPS), when entering the vascular bed, increases the systemic endotoxin level in general. Inflammation-causing cytokines and LPS in NAFLD contribute to the formation of an anaerobic environment in the periodontium that favours the quantitative growth of P. gingivalis. Conclusion: The highest levels of P. gingivalis and gingipain were recorded in patients with NAFLD, which is consistent with a background of decreased periodontal adaptive capabilities. The P. gingivalis/gingipain correlation ratio can allow the dentist to monitor the treatment of periodontal patients. | uk_UA |
dc.language.iso | en | uk_UA |
dc.publisher | Journal of the Italian Society of Orthopaedics and Medicine (OrtoMed). Publisher: Rome: Medimay. Country | uk_UA |
dc.subject | periodontitis | uk_UA |
dc.subject | chronic inflammation | uk_UA |
dc.subject | gingipain | uk_UA |
dc.subject | periodontopathogen | uk_UA |
dc.title | Porphyromonas gingivalis and non-alcoholic fatty liver disease as combined factors of periodontitis | uk_UA |
dc.type | Article | uk_UA |
dc.identifier.doi | https:doi.org/10.57582/IJBF.220202.072 | - |
Розташовується у зібраннях: | Наукові праці. Кафедра терапевтичної стоматології |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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Porphyromonas_gingivalis_and_non_alcoholic_fatty_liver_disease.pdf | 395,96 kB | Adobe PDF | Переглянути/Відкрити |
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