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Title: Targeting oxidative stress mechanisms to treat Alzheimer's and Parkinson's disease: a critical review
Authors: Aborode, Abdullahi Tunde
Pustake, Manas
Awuah, Wireko Andrew
Alwerdani, Mariam
Shah, Parth
Yarlagadda, Rohan
Ahmad, Shahzaib
Correia, Inês F. Silva
Chandra, Ayush
Nansubug, Esther Patience
Abdul-Rahman, Toufik
Mehta, Aashna
Ali, Omar
Amaka, Shekinah Obinna
Zuñiga, Yves Miel H.
Shkodina, A. D.
Inya, Oko Christian
Shen, Bairong
Alexiou, Athanasios
Шкодіна, Анастасія Дмитрівна
Issue Date: 2022
Publisher: Hindawi
Citation: Targeting oxidative stress mechanisms to treat alzheimer's and parkinson's disease: a critical review / A. T. Aborode, M. Pustake, W. A. Awuah [et al.] // Oxidative Medicine and Cellular Longevity. – 2022. – Article ID 7934442. doi: 10.1155/2022/7934442.
Abstract: Neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are becoming more frequent as the age increases. Contemporary therapies provide symptom resolution instead of targeting underlying pathological pathways. Consequently, there is considerable heterogeneity in response to treatment. Research has elucidated multiple potential of pathophysiological mechanisms contributing to neurodegenerative conditions, among which oxidative stress pathways appear to be suitable drug targets. The oxidative stress pathway has given rise to numerous novel pharmacological therapies that may provide a new avenue for neurodegenerative diseases. For example, SKQ (plastoquinone), MitoVitE, vitamin E, SOD mimic, MitoTEMPO (SOD mimetic), and bioactive molecules like curcumin and vitamin C have indeed been examined. To better understand how oxidative stress contributes to neurodegenerative diseases (such as Alzheimer’s and Parkinson’s), we analyzed the medicinal qualities of medicines that target markers in the cellular oxidative pathways. The specific pathway by which mitochondrial dysfunction causes neurodegeneration will require more investigation. An animal study should be carried out on medications that tackle cellular redox mechanisms but are not currently licensed for use in the management of neurodegenerative conditions.
Keywords: alzheimer’s disease
parkinson’s disease
oxidative Stress
Appears in Collections:Наукові праці. Кафедра нервових хвороб

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