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http://repository.pdmu.edu.ua/handle/123456789/2107
Назва: | Multimorbidity in the patients with diabetes mellitus and arterial hypertension as basis for difficulties in diagnostics and treatment |
Автори: | Kulishov, S. K. Iakovenko, O. M. Prikhodko, N. P. Tretiak, N. G. Sulaiman, M. Кулішов, Сергій Костянтинович Яковенко, Олександр Михайлович Приходько, Наталія Петрівна Третяк, Наталія Григорівна |
Дата публікації: | 2012 |
Бібліографічний опис: | Multimorbidity in the patients with diabetes mellitus and arterial hypertension as basis for difficulties in diagnostics and treatment /S. K. Kulishov, O. M. Iakovenko., N. P. Prikhodko [at all] // Programme& Abstracts The 4th World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension, 8–11 November, Barcelona, Spain. – 2012. – P. 19 |
Короткий огляд (реферат): | Aim. Identify multimorbidity triggers in the patients with diabetes mellitus (DM) and arterial hypertension (AH) to optimize the quality of diagnosis, treatment. Patients and Methods: The study involved 81 patients with various combinations of DM (including 5 – with 1st DM) with AH and acute or chronic coronary artery disease (CAD), pathology of the digestive system. Research methods included biochemical, hemostatic, metabolic parameters, cardiac biomarkers, interleukin-10 (IL-10), high sensitive C-reactive protein, auto-antibodies to chaperone 60 (anti-Hsp 60); daily arterial pressure (AP), electrocardiographic monitoring. We used the MiniMed Paradigm Real-Time insulin pump and continuous glucose monitoring system for 1st DM patients. Statistical parametric and nonparametric analysis was made using SPSS v. 13.0. Results: The main predictors of complicated course of CAD in the patients with DM and AH was instability of the glycemic profile, increasing the amount of monocytes and neutrophils above 75% , the index value of leukocytes to the blood cholesterol more than 1,21 conventional union, anti-Hsp 60 over 66,67 ng/ml, IL-10 less than 70 pg/ml (P by ANOVA, Kruskal-Wallis tests <0,05). Diastolic blood pressure and heart rate multiplied by the systolic blood pressure have a direct correlation average force (r=0.645, P=0.0001). AP elevation and hyperglycemia was observed in 84,4% of episodes (P<0.01 by criteria of sign). CONCLUSION: Multimorbidity triggers in the patients with DM and AH are the instability of the glycemic profile, disturbances of lipid metabolism, consumption syndromes of pro-inflammatory and anti-inflammatory, pro-ischemic and anti-ischemic factors. It’s may be basis to optimize treatment, overcoming polypharmacy. |
URI: | http://repository.pdmu.edu.ua/handle/123456789/2107 |
Розташовується у зібраннях: | Наукові праці. Кафедра внутрішньої медицини № 1 |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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multy_in_the_with_diabet.pdf | 126,12 kB | Adobe PDF | Переглянути/Відкрити |
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