Please use this identifier to cite or link to this item: http://repository.pdmu.edu.ua/handle/123456789/2239
Title: Effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease
Authors: Chekalina, N.
Shut`, S.
Trybrat, T.
Burmak, Yu.
Petrov, Ye.
Manusha, Y.
Kazakov, Yu.
Чекаліна, Наталія Ігорівна
Шуть, Світлана Володимирівна
Трибрат, Тетяна Анатоліївна
Бурмак, Юрій Григорович
Петров, Євген Євгенович
Мануша, Юлія Іванівна
Казаков, Юрій Михайлович
Issue Date: 2017
Publisher: Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy” — Poltava, Ukraine
Citation: Effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease / N. I. Chekalina, S. V. Shut`, T. A. Trybrat [et al.] // Wiadomosci Lekarskie. – 2017. – Vol. LXX, № 4. – P. 707–711.
Abstract: The aim: The aim of our research was to study the effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease (CHD). Material and methods: The research involved 85 patients with CHD: stable angina pectoris, FC II, and 30 healthy individuals made up the control group. After 1.5 months of stabilizing therapy (β-blockers, statins, aspirin) patients with CHD were randomized into 2 groups — the research group (30 people) and the comparison group (55 people). Quercetin at a dose of 120 mg per os daily was added to standard treatment of the patients of the research group (with CHD), patients of the comparison group continued receiving the same treatment. The day before randomization and 2 months after prescribing differentiation therapy to the patients, echocardiography (echo) and 24 hour Holter ECG monitoring were made. Results: Clinical evaluation of echocardiography revealed that diastolic dysfunction of the left ventricle (LV) had been found in 100% of patients studied: in 97.6% — in the form of violation of relaxation (type I), in 2.4% of patients — in the form of pseudonormalization (type II). The 24 hour Holter ECG monitoring revealed episodes of myocardial ischemia (10.7+2.7 episodes a day), premature atrial contractions (PACs) and premature ventricular contractions (PVCs) in patients with stable CHD. After a two-month term of therapy in patients of both research and comparison groups left ventricular systolic function in terms of ejection fraction (EF) of LV significantly improved (by 4.5% and 3.2% respectively). LV diastolic function improved in both groups in terms of the ratio of the phases of the transmitral flow E/A, also IVRT significance decreased (p<0.05). DT value dropped significantly influenced by quercetin, in the comparison group it didn`t change. According to the 24 hour Holter ECG monitoring, the total time and number of episodes of ST segment depression decreased with dominative results in quercetin group. PVC number was significantly reduced only by influence of therapy with quercetin (р=0.0022). Conclusions: The data have shown cardioprotective properties of quercetin in conditions of CHD.
Keywords: coronary heart disease
quercetin
central hemodynamics
myocardial ischemia
echocardiography
24 hour Holter ECG monitoring
ISSN: 0043-5147
URI: http://elib.umsa.edu.ua/jspui/handle/umsa/2239
Appears in Collections:Наукові праці. Кафедра пропедевтики внутрішньої медицини

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