Histological features of rats’ normal lung tissue

Abstract

Modeling on laboratory animals is widely used for experimental morphological studies. To interpret the findings properly it is crucial to know the specific differences of their anatomical organization. The purpose of the research was the study of histological features of normal lung texture of Wistar white rats. Histological analysis showed that areas of destructive changes of alveolar walls with accumulation of alveolocytes in the alveoli lumen on different stages of destruction, as well as fibrin and individual red blood cells were observed in some of the test samples of rats’ normal lung tissue. In the hollows of some alveoli few alveolar macrophages and the Type II alveolocytes were found. The special feature of hemomicrocirculatory flow of rats’ normal lungs is accumulation of erythrocyte in the capillaries of alveolar septums. In the areas of erythrocyte accumulation a local damage, destruction and demolition of cytolemma of capillaries endothelium has been detected, resulted in endothelium basal membrane exposure and accumulation of pinocytic vesicles in the lumen of capillaries.