Please use this identifier to cite or link to this item:
http://repository.pdmu.edu.ua/handle/123456789/2463
Title: | Особенности воздействия пептидного комплекса почек на экспрессию антигенных детерминант лимфоцитов, обработанных интерлейкином-2 и гидрокортизоном |
Other Titles: | Peculiar influence of the kidney peptide complex on expression of antigenic determinants of the lymphocytes treated by interleukin-2 and hydrocortisone |
Authors: | Веснина, Людмила Эдуардовна Кайдашев, Игорь Петрович Vesnina, L. Kaidashev, I. Кайдашев, Ігор Петрович Весніна, Людмила Едуардівна |
Issue Date: | Mar-2000 |
Publisher: | Медицина |
Citation: | Веснина Л. Э. Особенности воздействия пептидного комплекса почек на экспрессию антигенных детерминант лимфоцитов, обработанных интерлейкином-2 и гідрокортизоном / Л. Э. Веснина, И. П. Кайдашев // Иммунология. – 2000. – № 2. – С. 17–21. |
Abstract: | We studied the influence of the peptide complex obtained from the kidney cortex substance on the expression of antigenic determinants CD3, CD4, CD8, CD72 and H LA-DR of peripheral blood lymphocytes during the action of interleukin-2 (IL-2) and hydrocortisone. The indirect immunofluorescence reaction has shown that IL-2 increased CD4, CD8, CD72 and CD3, HLA-DR expression. The treatment with the kidney peptide complex (KPC) enhanced CD3 expression and reduced CD4, CD8 and CD72 expression precultured with IL-2. Hydrocortisone decreased CD3, CD4, CD8 expression and increased HLA-DR expression. KPC increased CD3 and CD8 expression and decreased that of CD4 and HLA-DR. It is suggested that KPC has an immunomodulative effect at the memebrane level. It changes early activation of immunocompetent cells modulating enzymes activity in the signal transduction. A direct influence on cell membrane is not excluded. Thus, regulative peptides take part in regulation of the lymphocyte function. |
URI: | http://repository.pdmu.edu.ua/handle/123456789/2463 |
Appears in Collections: | Наукові праці. НДІ ГІОРПФ |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.