Экспрессия мембранных рецепторов лимфоцитов под влиянием пептидного комплекса почек на фоне действия иммуномодуляторов

Abstract

We studied the effect of a peptide extract from renal cortex on expression of lymphocyte surface immunoglobulin receptors under the action of endogenic immunomodulators 1L-2 and hydrocortisone in direct immunofluorescence reaction. We found out maximal fluorescence (as single clusters and patches), in incubation of lymphocytes with IL-2 (1:8). IL-2 incubation with the peptide extract increased binding of the cells with the antibodies. Hydrocortisone induced a decrease in fluorescence and disappearance of receptor rearrangement. In this case the peptide complex increased amount of fluorescent cells two-fold. The findings suggest that peptide molecules may be involved into interaction between immunocytes and special parenchymal.cells which is controlled by immunomodulators.