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Title: Diagnostic algorithm and peculiarities of monitoring for infants with disorders of the gastrointestinal tract
Other Titles: Діагностичний алгоритм і особливості спостереження за дітьми раннього віку з гастроінтестинальними розладами
Authors: Kryuchko, T. A.
Крючко, Тетяна Олександрівна
Nesina, I. M.
Несіна, Інна Миколаївна
Tkachenko, O. Ya.
Ткаченко, Ольга Ярославівна
Крючко, Татьяна Александровна
Несина, Инна Николаевна
Ткаченко, Ольга Ярославовна
Issue Date: 2017
Publisher: Wydawnictwo Aluna
Citation: Kryuchko T. O. Diagnostic algorithm and peculiarities of monitoring for infants with disorders of the gastrointestinal tract / T. O. Kryuchko, I. M. Nesina, O. Ya.Tkachenkо // Wiadomości Lekarskie. — 2017. — T. LXX, nr 2, cz II. — S. 275—282.
Abstract: Introduction: The most common medical conditions in infants, which belong to pediatric and gastroenterological disease areas, are functional gastrointestinal disorders, food hypersensitivity and food allergy. First of all, these symptoms can disguise lactase deficiency, cow’s milk protein allergy, eosinophilic gastroenteritis, allergic proctocolitis, gastrointestinal manifestations of atopic dermatitis, functional disorders of gastrointestinal and biliary tract, etc. The aim of our study was to develop an algorithm of monitoring for infants with disorders of the gastrointestinal tract and to study the efficacy of probiotic and enzyme replacement therapy. Materials and metods: 47 children aged 1 to 3 years with gastrointestinal and atopic dermatitis symptoms underwent clinical and laboratory examinations. Results: Analysis of additional examination revealed the causes of gastrointestinal disorders, and the following diagnoses were made: 15 children (32 %) had secondary lactase deficiency, 9 children (19 %) had sensitization to cow’s milk protein and caseins. Molecular-genetic analysis of С > Т polymorphism at position 13910 of lactase gene (LСT) demonstrated that C/C-13910 genotype was observed in 44.7 % of children, С/Т-13910 heterozygous genotype was found in 36.2 %, and 19.1 % of children had Т/Т-13910 genotype; these were interpreted in conjunction with other clinical criteria for verification of secondary lactase deficiency diagnosis. Conclusions: Assessment of children over time during their treatment showed that combined therapy using lactase preparation and probiotics contributed to relief of clinical symptoms. All patients had their fecal pH increased (> 5.5), whereas the majority of children demonstrated improvement yet on days 2–3 (i.e., decrease in pain syndrome, flatulency, and stool frequency; restoration of normal stool consistency). Based on the obtained data, we proposed a practical algorithm for verification and monitoring of children with gastrointestinal disorders.
Keywords: infants
functional gastrointestinal disorders
food allergy
lactase deficiency
діти раннього віку
функціональні гастроінтестинальні розлади
харчова алергія
лактазна недостатність
Appears in Collections:Наукові праці. Кафедра педіатрії № 2

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