Please use this identifier to cite or link to this item: http://repository.pdmu.edu.ua/handle/123456789/7875
Title: Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease
Authors: Chekalina, N.
Burmak, Y.
Petrov, Ye.
Borisova, Z.
Manusha, Y.
Kazakov, Yu.
Kaidashev, I. P.
Кайдашев, Ігор Петрович
Чекаліна, Наталія Ігорівна
Бурмак, Юрій Григорович
Петров, Євген Євгенович
Борисова, Зінаїда Олексіївна
Мануша, Юлія Іванівна
Казаков, Юрій Михайлович
Issue Date: 2018
Publisher: Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy”, Str. Shevchenka, 23, 36000, Poltava, Ukraine
Citation: Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease [Electronic resource] / N. Chekalina, Yu. Burmak, Ye. Petrov [et al.] // Indian Heart Journal. – 2018. – V. 70, Issue 5. – P. 593–597. – URL: https://doi.org/10.1016/j.ihj.2018.04.006
Abstract: The aim of this study was to determine the effect of quercetin on the indicators of chronic systemic inflammation (CSI) in stable coronary artery disease (CAD). Methods: This study included 85 patients with CAD, stable angina pectoris, functional class (FC) II, and heart failure (=F) 0-y. Each patient was prescribed beta-blockers, statins, and aspirin. In addition, a total of 30 patients, forming the study group received quercetin at a daily dose of 120 mg for two months, while the remaining 55 patients made up the control group. The levels of cytokines, such as tumor necrosis factor (TNF-a), interleukin-1b (IL-1b), and interleukin-10 (IL-10) in serum and the expression of the inhibitor of kappa B a (IkBa) gene in blood mononuclear cells, were determined.
Keywords: Coronary artery disease
Quercetin
Chronic systemic inflammation
Cytokines
Nuclear factor of transcription kappa B
ISSN: 0019-4832
URI: http://elib.umsa.edu.ua/jspui/handle/umsa/7875
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