Роль антиоксидантов и антигипоксантов в комплексном лечении одонтогенной флегмоны челюстно-лицевой области

Abstract

Мета роботи - систематизація данних спеціальної літератури для найбільш чіткого визначення напрямків вивчення ефективності застосування антиоксидантних і антігіпоксантних препаратів у комплексному лікуванні хворих з гнійно-запальними захворюваннями щелепно-лицевої ділянки. У представленій оглядовій статті показаний аналіз результатів застосування антиоксидантної та антігіпоксантної терапії при гнійно- запальних процесах різної локалізації. Визначено напрямки дослідження впливу антиоксидантної та антігіпоксантной терапії на біологічно-біохімічні показники тканин щелепно-лицевої ділянки та організму хворого в цілому; OBJECTIVE : Among the urgent problems of surgical dentistry issue of improving the methods of diagnosis and treatment of inflammatory diseases of the maxillofacial area is one of the leading. This is due to the frequency of occurrence and severity of complications of this pathology , despite holding a whole range of preventive measures. Tendency to increase the number of such patients have a 60 - 70 - hgodov last century and , despite the measures taken has no tendency to decrease . According to the Department of Maxillofacial Surgery , about 50 % of patients admitted to hospital undergoing treatment for inflammatory processes of the maxillofacial region . Along with this increased interest in specialists to study acute odontogenic infection maxillofacial currently explained by polymorphism of microbial associations and the emergence of antibiotic-resistant strains causing inflammation, atypical clinical picture of the disease and the lack of efficacy of standard treatments . However, the lack of conclusive data on the biochemical mechanisms underlying the basis and development of acute odontogenic infection and reliable diagnostic and prognostic tests difficult to assess the severity of disease and clinical entities timeliness pathogenetic treatment of choice , which often leads to the development of mediastinitis , facial vein thrombophlebitis , thrombosis of the cavernous sinus , meningitis, sepsis and other complications are often the cause of disability and death . Thus, it appears that further study of the etiology and pathogenesis , improved methods of diagnosis and treatment of inflammatory diseases of the maxillofacial area , remains as the most important problem in modern dentistry and maxillofacial surgery . At this stage, there is no doubt that aggressiveness infectious agent and the state of nonspecific resistance physiological systems , mechanisms of adaptation of the body in many ways determine the possibility of character development and outcome of acute inflammatory processes admaxillary soft tissues. In recent years, much attention is paid to clarify the role of free radical oxidation in normal and pathological state, defining the location of antioxidants and antihypoxants correction and regulation of free radical oxidation (CPO ) . Imbalance in the system and antioxidant protection SRO characteristic of oxidative stress is an important pathogenic factor in the development of the disease.