Сomplex diagnostics of ulceroinfiltrative gastric cancer (english version).

Abstract

Complex diagnostics, made by the histological method, specifying the mitotic regimen, immunohistochemical Ki-67 marker (MIB-1clone) and ISSR-PCR marker of genetic typing showed lesions in gastric mucosa epithelium, specific to gastric mucosa epithelium neoplasia in patients with ulceroinfiltrative gastric cancer. Expansion of ISSR-PCR marker of genetic typing indicates its high sensitivity and informativeness. There is a strong correlation between the indices of histological, immunohistochemical and indices of genetic typing, detected by the ISSR-PCR method. Between the indices of mitotic regimen, proliferative activity of gastric mucosa epithelium of Ki-67 marker and indices of genetic typing of gastric mucosa epithelium, the Pearson's correlation coefficient, rxy, constitutes 0,197, 0,607 and 0,881, respectively, corresponding to the existence of moderate and considerable relationship between indices. The overall result shows statisticaiiy significant dependence with probability of 0,99.