The level of systemic inflammation and the state of central hemodynamics in patients with coronary heart disease

Abstract

Materials and methods. An open clinical trial was conducted. 230 patients with CHD were examined: stable angina pectoris, II FC, CH 0-I (119 men and 111 women aged 57 + 8.3 years) and 30 healthy subjects (control group). The criteria for inclusion in the study were the age of men and women (40-75 years), the presence of CHD: exertional angina of II FC in the absence of destabilization of the course for at least two months, the informed consent of the patient to participate in the study. The exclusion criteria were the presence of chronic heart failure higher than stage I, high blood pressure, complications of cardiac rhythm and conduction disorders, rheumatism, cancer, anemia, diabetes mellitus, renal and hepatic insufficiency. To achieve the aim of the research, patients’ blood was tested for levels of IL-1β and TNFα by the immune enzyme method; fibrinogen (FG) plasma levels – by weight method and echocardiography (echo) [7]. The global contractile ability of LV was estimated by the stroke volume (SV), the ejection fraction (EF), and the velocity of the blood flow (v) in the external path (EP) of the LV. The diastolic function of LV was investigated by recording the transmitral blood flow rates by the ratio of the velocities of the early (E) and late (L) diastolic filling of the LV (E / A), the delay time of early diastolic filling of the LV (DT) and the time of isovolumic LV relaxation (IVRT) [7].