Efficiency of local therapy with the use of a new preparation for oral care at periodontitis in the course of hyperpeptic gastritis after tobacco smoke intoxication

Abstract

Introduction: Periodontal diseases, arising against a background of stomach pathology at tobacco addiction remain an acute problem of modern dentistry. The aim of the work is an experimental study of efficiency of application of the new preparation for oral care during treatment of periodontitis simulated against a background of hyperpeptic gastritis under conditions of intoxication by tobacco smoke. Materials and methods: At the first stage all experimental animals were divided into 4 groups: І - intact, II - with simulated periodontitis, III - with simulated periodontitis against a background of simulated hyperpeptic gastritis, IV - with simulated periodontitis against a background of hyperpeptic gastritis under conditions of tobacco smoking. Biochemical researches at periodontitis in rats were conducted for determination of influencing stomach pathology and tobacco smoke. On the II stage efficiency of local therapy was studied with the use of the new preparation for oral care and a comparator agent.Results: At experimental periodontitis against a background of hyperpeptic gastritis under conditions of smoking the considerable changes in periodontal tissues typical for the inflammatory process develop. The local therapy at rats with the use of the new preparation resulted in accelerating removing harmful influence of damaging factors and restoring the state of periodontal tissues, than in case of application of the comparator agent. Conclusions: The efficiency of the new preparation consists in normalizing influence on processes of lipid peroxidation, inflammation and activation of the protective systems of oral cavity during periodontitis which arises up against a background of hyperpeptic gastritis.