Світ медицини та біології. 2023

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https://repository.pdmu.edu.ua/handle/123456789/20379

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Перегляд Світ медицини та біології. 2023 за Автор "Boruta, N. V."

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    Characteristics of structural components of intrahepatic biliary tracts in humans
    (Полтавський державний медичний університет, 2023) Dubinin, D. S.; Shepitko, V. I.; Dubinin, S. I.; Stetsuk, Ye. V.; Boruta, N. V.; Levchenko, O. A.; Ulanovska-Tsyba, N. A.; Дубінін, Дмитро Сергійович; Шепітько, Володимир Іванович; Дубінін, Сергій Іванович; Стецук, Євген Валерійович; Борута, Наталія Володимирівна; Левченко, Ольга Анатоліївна; Улановська-Циба, Наталія Аркадіївна
    Among the most common diseases of the hepatobiliary system are chronic cholecystitis, cholangitis, gallstone disease, and post-cholecystectomy syndrome, which are increasingly prevalent. Gallstone disease affects more than 10 % of the adult population in various countries around the world. There is a doubling of the number of patients every ten years in all economically developed countries. This pathology is found in women 3-4 times more often than in men. The incidence of the disease increases with age. The intrahepatic bile ducts of humans consist of two layers: an outer adventitial layer and an inner mucosal layer. In the initial part of the liver's biliary system, the biliary pathways in the mucous membrane are composed of cuboidal epithelium resting on the basal membrane. In the middle section of the human biliary system, not only cuboidal but also columnar epithelial cells appear. In the terminal section of the biliary system, the number of columnar epithelial cells in the inner lining increases. Epithelial cells change their shape from cuboidal to columnar. The outer layer is composed of loose connective tissue, with fibroblastic cell rows and an intercellular substance containing collagen fibers and amorphous material.
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    Morphofunctional characteristics of the structural components of the pancreas exocrine part in chemical castration
    (Полтавський державний медичний університет, 2023) Boruta, N. V.; Shepitko, V. I.; Stetsuk, Y. V.; Dubinin, D. S.; Levchenko, O. A.; Sydorenko, A. V.; Mykhaylenko, V. V.; Борута, Наталія Володимирівна; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Дубінін, Дмитро Сергійович; Левченко, Ольга Анатоліївна; Сидоренко, Андрій Вячеславович; Михайленко, В. В.
    Throughout a person's life, the pancreas, which is the second largest gland (after the liver), is significantly affected by various adverse factors. It is a unique organ that combines external and internal secretory activity, playing an important role in the carbohydrate metabolism of the human body. Today, diseases of the pancreas are one of the most important problems in medicine. Established dystrophic changes of the gland, which were expressed by the formation of fibrous fields, the thickness of the capsule and interlobular connective tissue between the lobes visually increased, a decrease in the area of acini and exocrinocytes was observed, acini lost clear contours and shape due to swelling of the connective tissue. Exocrinocytes of acini lost apical eosinophilia and basal basophilia of the cytoplasm, there was a decrease in the area of the nuclei, which were changed in shape and location. The introduction of triptorelin causes destructive-degenerative changes in the exocrine apparatus of the pancreas, which are characterized by compensatory mechanisms in the early periods of observation, and in the later periods – dystrophic changes in the structural components of the gland are determined, which corresponds to the stage of partial decompensation, a decrease in the activity and functionality of the cellular component of the exocrine apparatus of the pancreas.
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    Morphogenesis of the minor salivary glands of the hard palate during triptorelin administration in the early observational terms in rats
    (Полтавський державний медичний університет, 2023) Shepitko, V. I.; Stetsuk, Ye. V.; Shtepa, K. V.; Boruta, N. V.; Voloshyna, O. V.; Pelipenko, L. B.; Serbin, S. I.; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Штепа, Катерина Вікторівна; Борута, Наталія Володимирівна; Волошина, Олена Валеріївна; Пелипенко, Лариса Борисівна; Сербін, Сергій Ігорович
    Minor salivary glands are very sensitive to pathological processes in the body. However, until now, the reactivity of minor salivary glands in response to neuroendocrine changes in the body has not been sufficiently studied and is, therefore, one of the unsolved problems of modern morphology. Triptorelin administration has a negative effect on the structural components of the secretory and excretory ducts of the minor salivary glands of rats. They were manifested by a statistically significant increase in all structural elements with a maximum on the 30th day, without restoring them to the indicators of the control group on the 180th. Comparing the morphometric indicators of the experimental group on the 30th and 180th days, a statistically significant decrease in morphometric indicators was determined. Mucous cell height decreased by 21 %, the outer diameter of the terminal secretory unit – by 22 %, the lumen of the terminal secretory unit – by 27 %; the height of the principal cells of the excretory ducts – by 9 %, the outer diameter of the excretory ducts – by 24 %, the lumen of the excretory ducts – by 27 %. In our opinion, this happened due to decreased compensatory properties of the tissues of the minor salivary glands.
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    Quantitative and qualitative changes in red bone marrow monocyte dipherone and microenvironmental cells during long-term triptorelin acetate administration in the experiment
    (Полтавський державний медичний університет, 2023) Martynenko, R. V.; Shepitko, V. I.; Pelypenko, L. B.; Boruta, N. V.; Martynenko, V. B.; Vilhova, O. V.; Stetsuk, Y. V.; Мартиненко, Роман Віталійович; Шепітько, Володимир Іванович; Пелипенко, Лариса Борисівна; Борута, Наталія Володимирівна; Мартиненко, Віталій Борисович; Вільхова, Олена Вікторівна; Стецук, Євген Валерійович
    States. Huggins and Hodges demonstrated the therapeutic effect of testosterone deficiency in the gonads in the 1940s and thus confirmed the concept that prostate cancer is an androgen-dependent disease. Androgen deprivation therapy (ADT) is the main palliative treatment for men with locally advanced and metastatic prostate cancer, with the goal of reducing testosterone levels to the level obtained by surgical castration. The long-term chemical castration with triptorelin acetate leads to quantitative and qualitative changes in monocytic sprout cells at all levels of differentiation and proliferation with a complementary reaction of microenvironmental cells. The maximum quantitative changes in monocyte cells were observed at the 3rd month of the study, followed by a gradual recovery to the control group. Changes in the microenvironment cells: macrophages and reticular cells, were characterized by a stable reaction in the early stages of the study in the form of a decrease in the number and ratio of NSCs, with subsequent recovery of quantitative and qualitative changes to the level of the control group of animals. The adipocyte reacts at all stages of the study with a steady increase in quantitative and qualitative characteristics.