Вісник проблем біології і медицини, 2023, Випуск 2 (169)

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Перегляд Вісник проблем біології і медицини, 2023, Випуск 2 (169) за Автор "Boychenko, O. M."

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    Effectiveness of herbal antiseptics in the complex treatment of generalized periodontitis
    (Полтавський державний медичний університет, 2023) Moshel, T. M.; Gancho, O. V.; Boychenko, O. M.; Krutikova, A. D.; Мошель, Тетяна Миколаївна; Ганчо, Ольга Валеріївна; Бойченко, Ольга Миколаївна; Крутікова, Анна Дмитрівна
    Abstract. The source of antimicrobial agents in the treatment of periodontal diseases can be extracts from medicinal plants, the peculiarity of which is that their biologically active substances are in a certain ratio, which contributes to the optimal effect on the human body. Phytopreparations rarely cause allergic reactions, macro – and microorganism adaptation does not develop to them, they are low-toxic. The purpose of this research is to study the antimicrobial action and clinical effectiveness of the herbal antiseptic «Timsal» in comparison with the well-known drugs «Rotokan» and «Phytodent». The study of the antimicrobial activity of «Timsal», «Rotokan» and «Phytodent» was carried out by the method of serial dilutions. Museum strains were used as test cultures: gram-positive bacteria – Staphylococcus aureus, gram-negative – Escherichia coli, fungi – Candida albicans. The periodontological status of patients with chronic generalized periodontitis of the I and II degrees of severity against the background of the combined course of chronic cholecystitis and pancreatitis was determined on the basis of clinical examination, functional tests, indices of PMA, PI according to Russel, orthopantomography. The hygienic condition of the oral cavity was studied according to the Fedorov-Volodkina index. In the course of microbiological studies, it was established that «Rotokan» and «Phytodent» had a bactericidal effect only against E. coli at a concentration of 12.5% (1:32 dilution). Antiseptic «Timsal» had a bactericidal effect on S. aureus in the form of a 6% solution (dilution 1:16), and in relation to fungi of the genus C. albicans – undiluted preparation. After a course of treatment with the use of the herbal preparation «Timsal» in patients with generalized periodontitis, the intensity of gum inflammation decreased by 2,5 times, and the depth of periodontal pockets by 1,28 times. There was also an improvement in the hygienic condition of the oral cavity by 1,7 times. On the basis of clinical and laboratory indicators, the high clinical effectiveness of the use of «Timsal» in the form of instillations in periodontal pockets has been established.