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Документ 80-річчю з дня народження доктора медичних наук, професора Скрипнікова Миколи Сергійовича присвячується(Вищий державний навчальний заклад України "Українська медична стоматологічна академія", 2016) Білаш, Сергій Михайлович; Проніна, Олена Миколаївна; Білич, Анатолій Миколайович; Пирог-Заказнікова, Ангеліна Валеріївна; Коптев, Михайло Миколайович; Половик, Олександр Юрійович; Билаш, Сергей Михайлович; Пронина, Елена Николаевна; Билыч, Анатолий Николаевич; Пирог-Заказникова, Ангелина Валериевна; Коптев, Михаил Николаевич; Половик, Александр Юрьевич; Bilash, S. M.; Pronina, O. M.; Bilych, A. N.; Pirog-Zakaznikova, A. V.; Koptev, M. N.; Polovyk, A.Документ A clinical case of cluster headache in a patient with recurrent rhinosinusitis(Полтавський державний медичний університет, 2023) Moskalyk, O. Ye.; Bilash, S. M.; Pronina, O. M.; Rudnytska, Kh. I.; Dats, I. V.; Haba, M. Ye.; Москалик, О. Є.; Білаш, Сергій Михайлович; Проніна, Олена Миколаївна; Рудницька, Х. І.; Дац, І. В.; Габа, М. Є.Given the polygamy of symptoms of rhinosinusitis, including pain in the frontal part of the head, it is sometimes difficult to differentiate the cause of the latter. Therefore, patients with rhinosinusitis, in whom the nature of the pain is not typical, does not correspond to the severity of inflammation of the mucous membrane of the nasal cavity and paranasal sinuses, and is not amenable to treatment, need consultation with related specialists to determine further treatment tactics.Документ A clinical case of cluster headache in a patient with recurrent rhinosinusitis(Полтавський державний медичний університет, 2023-08-28) Moskalyk, O. Ye.; Bilash, S. M.; Pronina, O. M.; Rudnytska, Kh. I.; Dats, I. V.; Haba, M. Ye.; Москалик, О. Є.; Білаш, Сергій Михайлович; Проніна, Олена Миколаївна; Рудницька, Х. І.; Дац, І. В.; Габа, М. Є.Rhinosinusitis is a widespread disease in most countries of the world, has an annual prevalence of 6-15% and is usually a consequence of Acute Respiratory Viral Infection. The purpose of our work was to study the clinical case of a patient with cluster headaches on the background of recurrent rhinosinusitis. The article presents a clinical case of cluster headache in a patient with recurrent rhinosinusitis, who, according to the treatment protocol, was prescribed an antibiotic, nasal rinsing with saline solutions, complex herbal preparations with decongestant, anti-inflammatory and secretolytic effects, analgesics and intranasal glucocorticoids. On the background of the prescribed treatment, inflammation of the mucous membrane of the nasal cavity and paranasal sinuses began to regress; however, the headache intensity did not change. Improvement in the patient’s general condition and clinical recovery was achieved only after consultation and treatment correction by a neurologist. This clinical case indicates that patients with rhinosinusitis, in which the nature of the pain is atypical, does not correspond to the severity of inflammation of the nasal mucosa and paranasal sinuses, and is not treatable, should consult related healthcare specialists to determine further treatment tactics.The analysis of clinical cases of patients with sinus pathology and the study of their structural features, innervation and blood supply significantly complement the teaching of human anatomical variability in age, gender and constitutional aspects.Документ A method for identifying the endocrine cells of the gastrointestinal tract on epoxy thin sections(Федеральное государственное автономное образовательное учреждение высшего образования "Крымский федеральный университет имени В.И. Вернадского" (Медицинская академия имени С.И. Георгиевского - структурное подразделение), 2013) Шепітько, Костянтин Володимирович; Шепітько, Володимир Іванович; Єрошенко, Галина Анатоліївна; Білаш, Сергій Михайлович; Шепитько, Владимир Иванович; Шепитько, Константин Владимирович; Ерошенко, Галина Анатольевна; Shepitko, V. I.; Shepitko, K. V.; Yeroshenko, G. A.; Bilash, S. M.Запропонований нами спосіб використовується для виявлення та оцінки кількості, розмірів, локалізації та ступеня враження ендокриноцитів в слизовій оболонкамиці шлунково-кишкового тракту при запальних процесах. Спосіб ідентифікації ендокриноцитів на тотальних препаратах включає в себе методику ущільнення тотального препарату в ЕПОН-812. Такий метод ущільнення, а потім імпрегнації солями срібла дає змогу ідентифікувати, визначити гістотопографію, кількісний та якісний склад ендокриноцитів на тотальному препараті в різних відділах шлунково-кишкового тракту та визначити ділянки для прицільного подальшого гістохімічного та електрономікроскопічного дослідження. Предложенный нами метод может применяться для выявления и оценки количества, размеров, локализации и степени поражения ендокриноцитив в слизистой оболочке желудочно-кишечного тракта при воспалительных процессах. Данный способ идентификации ендокриноцитив на тотальных препаратах включает в себя методику помещения тотального препарата в ЭПОН-812. Такой метод уплотнения, а затем импрегнации солями серебра позволяет идентифицировать, определить гистотопографию, количественный и качественный состав ендокриноцитив на тотальном препарате в различных отделах желудочно-кишечного тракта и определить участки для прицельного дальнейшего гистохимического и електрономикроскопичного исследования. Our method can be used to identify and to evaluate the quantity, sizes, location and degree of damage of endocrine cells in the mucosa of the gastrointestinal tract during the inflammatory processes. This method of identification of endocrine cells on total specimens includes a method of placing of total specimen in EPON 812. This compaction method and further impregnation with silver salts makes it possible to identify and to define the histotopography, the qualitative and quantitative composition of the endocrine cells on the total specimen in the different parts of the gastrointestinal tract and to define the areas for the further impact histochemical and electron-microscopic examination.Документ Abraham Flexner: a man, teacher, and reformer(Вісник проблем біології і медицини, 2024) Bieliaieva, O. M.; Bilash, S. M.; Lysanets, Yu. V.; Rozhenko, I. V.; Taran, Z. M.; Buhaienko, K. S.; Hurai, L. P.; Бєляєва, Олена Миколаївна; Білаш, Сергій Михайлович; Лисанець, Юлія Валеріївна; Роженко, Інеса Віталіївна; Таран, Зінаїда Михайлівна; Бугаєнко, Ксенія Сергіївна; Гурай, Людмила ПорфирьевнаEngaging in an interdisciplinary exploration at the crossroads of United States history and medical pedagogy, this study focuses on Abraham Flexner's biography. A thorough analysis unfolds against the backdrop of historical epochs shaping Flexner's impactful contributions. The study highlights the imperative nature of the radical reforms enacted in the early 20th century. Flexner led the way in these transformative actions, which included closing and radically reorganizing institutions that trained future doctors. This initiative was carried out at the request of the American Medical Association for Medical Education, with steadfast support from the Carnegie Foundation for the Advancement of Teaching. This paper highlights the necessity of these reforms for the "sanitation" and progressive evolution of both medical education and the US healthcare system, despite encountering staunch opposition from the academic and medical communities of the time. Central to the discussion are the criteria put forth by Flexner for evaluating the quality of medical education. Emphasizing crucial aspects like the quality of students, having an educational license, standardized admission procedures, a strong material and technical setup, qualified faculty, and students' access to clinical facilities, the study clarifies the essential role these elements played in Flexner's vision. The research sheds light on the success of Flexner's reforms, attributing a significant portion to his personal qualities and pedagogical education. His ability to dispassionately evaluate medical schools across the USA and Canada showcases the depth of his insights. Despite some critical remarks, the study emphasizes the invaluable contribution Flexner made to the radical transformation of the American medical school, elevating his figure to an almost legendary status.Документ Analysis of early morphological and functional perivulnar changes in the mucosa of the cecum after suturing with different surgical threads(Національний університет охорони здоров'я України імені П. Л. Шупика, 2024) Bilash, S. M.; Pronina, O. M.; Ksyonz, I. V.; Koptev, M. M.; Oliinichenko, Ya. O.; Kononov, B. S.; Білаш, Сергій Михайлович; Проніна, Олена Миколаївна; Ксьонз, Ігор Володимирович; Коптев, Михайло Миколайович; Олійніченко, Ярина Олександрівна; Кононов, Богдан СергійовичThe correct choice of suture material is the key to successful treatment in abdominal surgery, particularly pediatric surgery. Given this, experimental studies on the effect of sutures made with different surgical threads are one of the most urgent surgery needs. The aim – to conduct a comparative analysis of early morphological and functional changes in the perivulnar region of the mucosa of the rabbit cecum after suturing with polyglactin-910 and polycaprolactone modified with L-arginine. Materials and methods. The study was conducted on 25 rabbits aged 8–10 months in compliance with all bioethical standards and recommendations. The control group consisted of 5 animals; the first experimental group, in which synthetic surgical polyfilamentous absorbable suture polyglactin-910 was used to close the wound defect, and the second experimental group, in which monofilamentous absorbable suture polycaprolactone modified with L-arginine was used to close the wound defect, consisted of 10 rabbits each. All stages of surgical access and sampling of intact cecal wall tissues were performed in the control group. The rabbits of the experimental groups underwent colotomy followed by suturing of the large intestine with appropriate suture material. Each experimental group was divided into two subgroups 5 rabbits in each), in which the condition of the perivulvar region was studied on days 3 and 7, respectively. The animals were not euthanised; during the second operation, tissues of the cecum were taken from the sutured area and the formed scar at the appropriate time. Histological, semi-thin serial sections, electron microscopic, morphometric, and statistical methods were used. Discussion. The average thickness of the cecal mucosa after colotomy increased significantly on days 3–7 when using both surgical threads, but when using polycaprolactone modified with L-arginine, the above indicator was 63.06% and 22.46% lower, respectively, due to a decrease in hyperhydration of the connective tissue component of the mucosa, leukocyte infiltration in the perivulnar area and acceleration of reparative processes. Conclusions. Polycaprolactone modified with L-arginine has a positive effect on the course of morphological and functional processes in the perivulnar region of the rabbit cecum’s mucosa. In terms of its characteristics, it is not worse than polyglactin-910. У черевній хірургії, зокрема, дитячого віку, правильний вибір шовного матеріалу є запорукою успішного лікування. Зважаючи на це, експериментальні дослідження з вивчення впливу швів, накладених різними хірургічними нитками, є однією з нагальних потреб хірургії. Мета – провести порівняльний аналіз ранніх морфофункціональних змін у перивульнарній ділянці слизової ділянки сліпої кишки кролів при зшиванні поліглактином-910 та полікапролактоном, модифікованим L-аргініном. Матеріали та методи. Дослідження проведено на 25 кролях віком 8–10 місяців із дотриманням усіх біоетичних норм і рекомендацій. Контрольна група налічувала 5 тварин; перша експериментальна група, у якій для зашивання ранового дефекту використовували синтетичну хірургічну поліфіламентну розсмоктувальну нитку поліглактин-910, та друга експериментальна група, у якій для зашивання ранового дефекту користувалися монофіламентною розсмоктувальною ниткою полікапролактоном, модифікованим L-аргініном, складалися з 10 кролів кожна. У тварин контрольної групи проведено усі етапи оперативного доступу та забір інтактних тканин стінки сліпої кишки. Кролям експериментальних груп виконано колотомію з подальшим ушиванням товстої кишки відповідним шовним матеріалом. Кожну експериментальну групу поділено на дві підгрупи (по 5 кролів у кожній), у яких вивчали стан перивульнарної ділянки на 3 та 7-му добу відповідно. Евтаназію тварин не проведено, під час повторної операції у визначені строки взято тканини товстої кишки з ділянки накладання швів і сформованого рубця. Застосовано гістологічний, напівтонких серійних зрізів, електронномікроскопічний, морфометричний, статистичний методи. Результати. Показник середньої товщини слизової оболонки сліпої кишки після колотомії достовірно на 3–7-му добу зростав при використанні обох хірургічних ниток, але при застосуванні полікапролактону, модифікованого L-аргініном, вищеозначений показник був відповідно на 63,06% та 22,46% меншим за рахунок зменшення процесів гіпергідратації сполучнотканинного компонента слизової оболонки, лейкоцитарної інфільтрації у перивульнарній ділянці та прискорення репаративних процесів. Висновки. Полікапролактон, модифікований L-аргініном, позитивно впливає на перебіг морфофункціональних процесів у перивульнарній ділянці слизової оболонки сліпої кишки кролів та за своїми характеристиками не поступається поліглактину-910.Документ Application of platelet-riched plasma in the complex treatment of patients with complete dislocation of maxillary teeth(Полтавський державний медичний університет, 2024-03-20) Ivanytska, O. S.; Bilash, S. M.; Lychman, V. O.; Toropov, O. A.; Avetikov, D. S.; Horban, I. I.; Іваницька, Олена Сергіївна; Білаш, Сергій Михайлович; Личман, Віталій Олександрович; Торопов, Олександр Анатолійович; Аветіков, Давид Соломонович; Горбань, І. І.Restoring the connection between the tooth and the periodontium is the primary goal of complex treatment, which involves the formation of new bone and cement, restoring the periodontal ligament and blood supply to the pulp from the surrounding tissues. The study aimed to investigate the effect of platelet-rich plasma as a medium for temporarily storing a dislocated tooth on the regeneration and reconstruction of its tissues after replantation of an extracted tooth compared to saline and water. In this study, 30 adult male Wistar rats were used, and a tooth was extracted and then replanted. A fibroblast cell activity analysis was performed after 72 hours to determine cell viability. Cells incubated in platelet-rich plasma medium had a higher percentage of cell viability (82.7±5.1), followed by saline (74.3±4.2) with statistical significance (p>0.001). The minimum percentage was recorded in cells in the medium with tap water (68.8±3.9). The pulp, dentin and cementum of the group where the teeth were placed in platelet-rich plasma showed normal histological features, demonstrating optimal tissue remodelling and attachment to the surrounding bone. There were no signs of root resorption. In summary, this study used several temporary storage procedures and evaluated changes in histological events that occurred during the storage of extracted teeth and replantation until the time of recording of the success of the replantation. The study's results indicate the use of platelet-rich plasma as a storage medium, as it significantly preserves the viability of dental cells compared to water and saline solutions.Документ Axiological dimensions of medical deontology in pediatric surgery(ТОВ «Група компаній Мед Експерт», м. Київ, Україна, 2023) Dubinina, V. O.; Ksonz, I. V.; Bilash, S. M.; Abyzova, L.V; Bilanov, O. S.; Ksonz, V. I.; Дубініна, Віра Олександрівна; Ксьонз, Ігор Володимирович; Білаш, Сергій Михайлович; Абизова, Лариса Віталіївна; Біланов, Олег Сергійович; Ксьонз, Володимир ІгоровичPhilosophy and axiology constitute the worldview and methodological basis of medical deontolo gy, particularly in surgery. The genesis of knowledge about moral and ethical principles and the professional duty of a pediatric surgeon is presented in the form of a logical chain: philosophy – axiology – deontology – medical deontology – deontology in surgery – deontology in pediatric surgery. The process of forming the deontological competence of medical professionals in pediatric surgery will be successful if the organization of deontological training for future healthcare providers is based on principles of humanism, in compliance with the requirements of the social environment, and implemented in the educational process through a productive mechanism. No conflict of interests was declared by the authors.Документ Changes in venules of gum(Полтавський державний медичний університет, 2023-03-13) Oleksiienko, Vladyslav; Олексієнко, Владислав Віталійович; Bilash, S. M.; Pronina, O. M.In conclusion, while food additives can enhance the sensory qualities of food, their impact on the morphology of living tissues is a cause for concern. Further research is needed to better understand the effects of food additives on human health and to develop strategies to minimize their negative impact.Документ Clinical Anatomy and Operative Surgery of areas and organs of head, neck, chest and abdomen(Українська медична стоматологічна академія, 2018) Bilash, S. M.; Pronina, O. M.; Koptev, M. M.; Білаш, Сергій Михайлович; Проніна, Олена Миколаївна; Коптев, Михайло МиколайовичThe manual on clinical anatomy and operative surgery for international students specializing in medicine corresponds to the syllabus and curriculum of the subject. The main issues for practical training and also recommendations on the methodology of the subject are represented sequentially. The manual includes theoretical material, assignments for self-control, situational tasks and the list of recommended literature for self-training. It provides development of learning effectiveness of the students and is directed on mastering the subject "Clinical anatomy and operative surgery", gaining practical experience and skills which is of great importance in future medical practice.Документ Clinical thinking аs an important element of effective professional activity of the future medical worker(Полтавський державний медичний університет, 2023) Bobukh, V. V; Andreiko, S. S.; Bilanova, L. P.; Bilash, V. P.; Oliinichenko, Ya. O.; Shkolna, O. V.; Bilash, S. M.; Бобух, Валерія Валеріївна; Андрейко, Світлана Станіславівна; Біланова, Лариса Павлівна; Білаш, Валентина Павлівна; Олійніченко, Ярина Олександрівна; Школьна, Олена Віталіївна; Білаш, Сергій МихайловичClinical thinking plays a significant role in training highly qualified medical workers, as it creates the basis for transforming acquired knowledge into the ability to apply it in practical activities. For healthcare workers, the formation of professional competence is significant, a combination of a high level of theoretical knowledge, professional skills, practical skills, the creative potential of an individual and a culture of communication. A significant role in this is played by the ability of medical workers to think "clinically", to learn to express their own opinions, to analyze and think logically, and to react quickly and highly qualified in critical situations. The formation of clinical thinking begins already during training in a medical institution and is further improved during one's professional activity. In addition, various modern teaching methods play a significant role in forming clinical thinking. These include the case method, the business game method, the "brainstorming" method, as well as the use of situational tasks. All these methods aim to teach students to fulfil their professional duties with dignity and apply the acquired knowledge in practical activities. In addition, the combination of these methods contributes not only to the formation of clinical thinking but also has a direct impact on both creative and critical thinking since it is impossible to draw a clear line between these concepts, especially when it comes to medical workers. Therefore, nurses' combination of essential, creative and clinical thinking elements is a crucial element of effective professional activity.Документ Comprehensive morphological studies as an intergal part of modern medical science. Literature review(Українська медична стоматологічна академія, 2019-06-02) Білаш, Сергій Михайлович; Билаш, Сергей Михайлович; Bilash, S. M.; Проніна, Олена Миколаївна; Пронина, Елена Николаевна; Pronina, O. M.; Коптев, Михайло Миколайович; Коптев, Михаил Николаевич; Koptev, M. M.Сучасна анатомія синтезує дані суміжних і споріднених із нею дисциплін: гістології, цитології, ембріології, біохімії, порівняльної анатомії, фізіології тощо. Тому на сьогодні глибоке вивчення актуальних проблем морфології не можливе лише за допомогою рутинних морфологічних методів дослідження. Сучасні науковці-анатоми проводять комплексні дослідження, які дозволяють усебічно розглянути морфологічну проблему, яка ними вивчається. Метою роботи стало проаналізувати методологічні підходи українських вчених при проведенні сучасних морфологічних досліджень. Аналіз літературних даних показав що саме комплексні дослідження нині використовуються як у дослідженнях структурно-функціональних характеристик різних органів і систем, так і в науково-експериментальних морфологічних дослідженнях. Ефективне вирішення актуальних завдань морфології у наш час можливе лише завдяки проведенню комплексних досліджень, які дозволяють усебічно розглянути проблему, що вивчається;Современная анатомия синтезирует данные смежных и родственных с ней дисциплин: гистологии, цитологии, эмбриологии, биохимии, сравнительной анатомии, физиологии и др. Поэтому сегодня глубокое изучение актуальных проблем морфологии невозможно только с помощью рутинных морфологических методов исследования. Современные ученые-анатомы проводят комплексные исследования, которые позволяют всесторонне рассмотреть изучаемую морфологическую проблему. Целью работы стало проанализировать методологические подходы украинских ученых при проведении современных морфологических исследований. Анализ литературных данных показал, что именно комплексные исследования в настоящее время используются как в исследованиях структурно-функциональных характеристик различных органов и систем, так и в научно-экспериментальных морфологических исследованиях. Эффективное решение актуальных задач морфологии в наше время возможно лишь благодаря проведению комплексных исследований, которые позволяют всесторонне рассмотреть изучаемую проблему; Current anatomical studies synthesize data of related disciplines: Histology, Cytology, Embryology, Biochemistry, Comparative Anatomy, Physiology, etc. Nowadays, a comprehensive study of the current morphological problems requires new investigation methods and approaches. Modern scientists-anatomists carry out comprehensive studies applying new methods, which provide profound evaluation of the morphological problems. The aim: Methodological approaches of Ukrainian scientists while conducting modern comprehensive morphological studies have been analysed. Analysis of the literary data has determined, that the comprehensive investigations are currently used both in the studies on structural-functional characteristics of various organs and systems, and in scientific experimental morphological researches. Modern scientific morphological studies are mainly based on the comprehensive investigations, which are considered as the future of the medical science. Nowadays, the effective solution of current morphological problems is possible while carrying out comprehensive investigations, which provide extensive study of the problem.Документ Current studies of ukrainian researchers of stress impact on chest organs: literature review(Aluna, 2018) Vynnyk, N. I.; Koptev, M. M.; Sovhyrya, S. M.; Filenko, B. M.; Bilash, S. M.; Винник, Наталія Іванівна; Коптев, Михайло Миколайович; Совгиря, Світлана Миколаївна; Филенко, Борис Миколайович; Білаш, Сергій МихайловичIntroduction: Stress reactions allow the body to adapt to the various environmental factors using the universal complex of neurohumoral reactions. Excessive stress reduces adaptability of the body and can initiate the onset and development of various pathologies. In recent years, Ukrainian scientists have completed a series of studies on the analysis of various aspects of the stress effect on the body. Aim: The paper was aimed at the analysis of the national medical publications, devoted to the study of the impact of stress on the chest organs. Material and Methods: The bibliosemantic method has been used during the study. Findings of the contemporary scientific studies devoted to the effect of stress on the chest organs have been analyzed. Results: The analysis shows that despite a long history of stress-related investigations, the study of the problem of stress remains relevant to date. Scientific researches elicit the new aspects of the impact of stress on the body, particularly on the chest organs. Conclusion: Recent investigations of Ukrainian scientists assist In better understanding of the essence of the stress-related morphofunctional changes that occur in the lungs, heart and esophagus. The findings will be helpful in the search for ways to prevent and treat stress-induced pathological processes, since the problem of stress remains to be solved to date.Документ Features of anthropometric indicators and dimensions of the coronary sinus and relationships between these indicators in patients without coronary artery pathology(Official Journal of the Scientific Society of Anatomists, Histologists, Embryologists and Topographic Anatomists of Ukraine, 2023-07-11) Liulka, Ye. M.; Bilash, S. M.; Білаш, Сергій Михайлович; Люлька, Євген МиколайовичRecently, in Ukraine, there has been a significant increase in the possibilities of invasive treatment of cardiovascular pathologies, the number of open-heart cardiosurgical operations and endovascular interventions is increasing. Each of these interventions requires endovascular catheterization of the coronary venous sinus of the heart, the variety of anatomical features of which requires a detailed study of the anatomy of the venous system of the heart. The purpose of the work is to establish the features of the coronary sinus dimensions and anthropometric indicators in men and women without coronary artery pathology, as well as the relationships between these indicators. Weight, body length, body mass index, anterior-posterior size of the chest, as well as the dimensions of the coronary sinus were determined (the length of the coronary sinus from the mouth to the oblique atrial vein, the transverse size of the coronary sinus in the area of the mouth in the sagittal and axial planes, the transverse size of the coronary sinus in the middle third in the sagittal and axial plane, the transverse dimension of the coronary sinus at the level of the oblique vein of the atrium in the sagittal and axial plane) in 15 men and 9 women aged 44 to 60 years (average age according to the age classification of the World Health Organization) without pathology of the coronary arteries, who underwent CT coronary angiography at the "Amosov National Institute of Cardiovascular Surgery NAMS of Ukraine". Statistical processing of the obtained results was carried out in the license package "Statistica 6.0" using non-parametric estimation methods. As a result of the conducted research, the limits of the percentile range of anthropometric indicators and the size of the coronary sinus in men and women without coronary artery pathology were established. When analyzing the value of these indicators between men and women, only significantly higher values of body mass and length were established in men. Therefore, when analyzing the relationship between the dimensions of the coronary sinus and the anthropometric parameters of the body, the distribution of indicators by sex was not carried out. When analyzing the correlations between age, sex, weight, body length, body mass index, signs of body mass index (indicates underweight, equivalent to normal body weight, indicates the presence of excess weight, or is a sign of obesity) and the anterior-posterior size of the chest with almost all dimensions of the coronary sinus, multiple reliable direct strong (r=0.64 and r=0.67) and medium strength (r=0.44 and r=0.47), as well as unreliable medium strength direct correlations with the anterior-posterior size of the chest were established (r=0.40 in both cases). In addition, multiple nonreliable average strength direct correlations of more than half of coronary sinus dimensions were established with body weight (r= from 0.32 to 0.35). When analyzing the correlations between the sizes of the coronary sinus, multiple reliable direct strong (r= from 0.60 to 0.65) and medium strength (r= from 0.41 to 0.59), as well as unreliable medium strength direct (r= from 0.30 to 0.40) correlations were established with half the size of these indicators.Документ Features of the influence of ubistesin on the state of pulp microcirculation and the quality of the anesthetic effect during mandibular anesthesia in adolescent children(Полтавський державний медичний університет, 2022) Avetikov, D. S.; Lokes, K. P.; Bilash, S. M.; Pronina, O. M.; Streblovkyi, D. V.; Аветіков, Давид Соломонович; Локес, Катерина Петрівна; Білаш, Сергій Михайлович; Проніна, Олена Миколаївна; Стебловський, Дмитро ВалерійовичCurrently, in modern children's dentistry, various local anesthetics and methods of anesthesia are actively used, which affect the characteristics of pulpal blood flow and pulpal anesthesia in human teeth. This study aims to study the effect of ubisthesin injection during mandibular anesthesia on the state of pulp microcirculation and the quality and prolongation of the anesthetic effect in the treatment of molars and premolars of the lower jaw. Thirty adolescents who underwent treatment of medium and deep caries under mandibular anesthesia took part in the study. The pulp reopletismography technique was used to determine the quality of the effect of ubistezin on the above parameters. The Pulptest-Pro device was used to assess tooth sensitivity and pulp anesthesia. The obtained data made it possible to establish the probable absence of significant changes in the microcirculation of the pulp and the prolonged effect of this medicine on pain sensations and pain syndrome. The duration of mandibular anesthesia was 81.40 min for molars and 83.50 min for premolars. The impact of ubisthesin on blocking the inferior alveolar and lingual nerves without creating a depot of anesthetic, without reducing the blood flow of the pulp of molars and premolars of the lower jaw with the delayed removal of the local anesthetic solution from the affected tissues was established.Документ Frequency analysis of isolated and combined lesions of the maxillary and frontal sinuses according to X-ray data(Полтавський державний медичний університет, 2023) Rudnytska, Kh. I.; Moskalyk, O. E.; Pronina, O. M.; Bilash, S. M.; Chelpanova, I. V.; Chaly, I.-V. T.; Diskovska, Yu. B.; Рудницька, Х. І.; Москалик, О. Є.; Проніна, Олена Миколаївна; Білаш, Сергій Михайлович; Челпанова, І. В.; Чалий, І.-В. Т.; Дісковська, Ю. Б.One of the actual problems of modern otorhinolaryngology is a significant increase in the incidence of paranasal sinuses, in particular acute and chronic sinusitis, which, according to the literature, is 1.5-2% per year. The purpose of our research was to study and compare the frequency of isolated and combined sinusitis of the maxillary and frontal sinuses according to radiographic examination data. 100 anonymized radiographs of persons of mature age (50 men and 50 women) who were examined by referral for inflammatory lesions of the paranasal sinuses were analyzed. All images were taken in the occipito-mental projection according to Waters, which allowed visualization of the maxillary and frontal sinuses. Different variants of isolated or combined inflammatory lesions of the maxillary and frontal sinuses were found in the studied sample. Signs of one- or two-sided catarrhal or exudative sinusitis were observed in all processed Xrays. In 84% of the examined persons, a lesion of only the maxillary sinuses was diagnosed, in 16% of the examined, a combined lesion of the maxillary and frontal sinuses was detected. Not a single case of isolated frontitis was found in the studied sample. According to radiographic examination, inflammatory processes in the maxillary sinuses are observed 6 times more often than in the frontal sinuses. Isolated lesions of the maxillary sinuses are found 5 times more often than combined lesions of the maxillary and frontal sinuses.Документ Hodgkin's Lymphoma: Current Views on the Problem(Ectodermal Dysplasia Group Turkey, 2022) Vynnyk, N. I.; Koptev, M. M.; Filenko, B. M.; Starchenko, I. I.; Bilash, S. M.; Sydorenko, A. H.; Kokovska, O. V.; Sovhyria, S. M.; Proskurnya, S. A.; Pronina, O. M.; Винник, Наталія Іванівна; Коптев, Михайло Миколайович; Старченко, Іван Іванович; Білаш, Сергій Михайлович; Сидоренко, Антоніна Григорівна; Коковська, Оксана Валеріївна; Совгиря, Світлана Миколаївна; Проскурня, Сергій Анатолійович; Проніна, Олена МиколаївнаLymphogranulomatosis holds a unique position in both oncological and oncohematological studies owing to the extremely polymorphic morphology of tumor tissue, non-specific clinical presentations of the disease, and a high recovery rate ensured by modern treatment protocols. Analysis of the body of literature showed that the development of Hodgkin’s lymphoma is associated with malignant B-cell transformation, which is primarily observed in young people. Histologically, there can be distinguished classical and nodular forms with lymphoid predominance. In the classical form of Hodgkin’s lymphoma, Hodgkin’s and Reed-Sternberg’s cells predominate among tumor cells and are accompanied by reactive inflammation. Modern scientific advances make it possible to perform immunophenotyping of pathological cells and determine the histogenesis of lymphogranulomatosis, however, to the present moment, diagnosing Hodgkin’s lymphoma can pose a significant challenge even for experienced professionals, especially in atypical cases. In most cases, immunohistochemical examination can confirm the diagnosis of classical Hodgkin’s lymphoma. A panel comprising CD3, CD20, CD15, CD30, and PAX5 markers is usually enough for its initial identification. Modern treatment standards of the classical form make it possible to achieve remission in over 80% of cases. However, late complications associated with the impact of specific therapy significantly worsen the outcomes of Hodgkin’s lymphoma treatment. Therefore, choosing the optimal therapy for this category of patients remains controversial. Chemotherapy and radiation regimens need to be improved, as they are often accompanied by side effects and are difficult for patients to tolerate. At present, there is a need for further studies in prevention, diagnosis, and treatment of Hodgkin’s lymphoma.Документ Immunohistochemical characteristics of structural changes in the cortex and medulla of the adrenal glands under the influence of a food additive complex(Полтавський державний медичний університет, 2023) Donchenko, S. V.; Bilash, S. M.; Донченко, Світлана Владиславівна; Білаш, Сергій МихайловичNowadays, food additives are widely used worldwide. They allow you to give food a specific taste, store products for a longer time and improve their appearance. Consumers do not even understand or realize the presence of chemical impurities in their products. However, food additives, even in small amounts, can lead to diseases of the organs and systems of the body, and in this case they can affect the functioning of the adrenal glands.Документ Immunohistochemical characteristics of structural changes in the cortex and medulla of the adrenal glands under the influence of a food additive complex(Полтавський державний медичний університет, 2023) Donchenko, S. V.; Bilash, S. M.; Донченко, Світлана Владиславівна; Білаш, Сергій МихайловичThe data obtained during the experiment allow us to conclude that the influence of the complex of food addi tives sodium glutamate, sodium nitrite and Ponceau 4R is a mechanism of activation of the focus of inflammation and changes in the structural elements of the adrenal glands and hemomicrocirculatory bed. According to the data of an immunohistochemical study, it was established that in the cortex and medulla of the adrenal glands, Ki-67 positive cells are elements of the local protective barrier. The largest number of Ki 67-positive cells was determined in the walls of fenes trated capillaries that permeate the cortex and medulla of the adrenal glands. Ki-67-positive cells formed clusters of 2-10 cells at the border of the glomerular and reticular zones. The total number of Ki-67-positive cells varied ac cording to the week of the experimental study. Starting from the first week, the number of cells expressing Ki-67 increases dramatically in the adrenal cortex’s glomerular, fasciculate and reticular zones. In the fourth week of the experiment, the level of labeled cells with Ki-67 reached almost control values. However, at the 12th week, the number of cells expressing Ki-67 increases in the cortex and the medulla. On the 16th week, the indicators remain within the 12th week, with an increase in the number of Ki-67-positive cells in the fasciculate zone of the cortical substance of the adrenal glands.Документ Immunohistochemical characterization of mucosal glands of the human frontal sinus septum mucosa in normal state(WHO Office in Azerbaijan, 2023) Pronina, O. M.; Bilash, S. M.; Koptev, M. M.; Pirog-Zakaznikova, A. V.; Kononov, B. S.; Oliinichenko, Ya. O.; Donchenko, S. V.; Oleksiienko, V. V.; Mamai, O. V.; Проніна, Олена Миколаївна; Білаш, Сергій Михайлович; Коптев, Михайло Миколайович; Пирог-Заказнікова, Ангеліна Валеріївна; Кононов, Богдан Сергійович; Олійніченко, Ярина Олександрівна; Донченко, Світлана Владиславівна; Олексієнко, Владислав Віталійович; Мамай, Олександр ВолодимировичThe immunohistochemical characteristics of the glands of the mucous membrane of the septum of the human frontal sinus were studied in normal conditions. The study was conducted on 120 preparations of the glands of the mucous membrane of the septum of the frontal sinus in 52 corpses of people of both sexes aged from 30 to 87 years who died from causes not related to the pathology of the paranasal sinuses. Our study used such methods as collecting material from corpses and the subsequent method of preparing the material for histochemical studies, serial semi-thin sections, and immunohistochemical analysis. According to an immunohistochemical study, it was established that in the stroma of the septal glands, there are CD 3-positive cells, which are elements of the local protective barrier, as well as a large number of periacinar T-lymphocytes. The number of CD 20-positive cells is negligible in the periacinar connective tissue of the septum. The number of B lymphocytes in the periductal stroma was significant. Many plasma cells were identified in the periacinar stroma of both protein and mucous glands of the mucous membrane of the human frontal sinus. The cells formed chains of 10-12 cells along the basement membrane. The number of CD 138-positive cells in the periductal connective tissue was lower compared to the periacinar tissue.