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Документ Anti-inflammatory activity of resveratrolin coronary heart disease(Publishing Group "Vědecká perspektiva", 2023) Chekalina, N. I.; Чекаліна, Наталія ІгорівнаTreatment of Coronary Heart Disease (CHD) remains an open pressing issue of modern medicine. Worldwide, despite the numerous methods of correction of CHD that are being developed, there has been no improvement in the situation with morbidity and mortality. In developed countries, CHD remains in the first place in the structure of mortality from all causes. In Ukraine over the past decade, CHD accounted for 65-68% of all deaths in the structure of cardiovascular diseases (CVD). Among the able-bodied population in Ukraine, CHD leads to disability in 38.5%, and the average age of patients becomes younger.Документ Anti-inflammatory effects of resveratrol in stable coronary artery disease and concomitant autoimmune thyroiditis(2016) Chekalina, N. I.; Чекалина, Наталья Игоревна; Чекаліна, Наталія ІгорівнаThis study aims to examine the effect produced by resveratrol on markers of chronic systemic inflammation in patients with coronary artery disease (CAD) and concomitant autoimmune thyroiditis (Hashimoto's thyroiditis).The study enrolled 85 patients with coronary artery disease: stable exertional angina, class II, 30 of them were found out to have diagnosis of autoimmune thyroiditis (AIT) in its euthyroid state (experimental group), 55 patients made up the control group. In a month of CAD stabilization therapy (β-blockers, statins, aspirin), the levels of interleukin-1β (IL-1β), IL-10, tumor necrosis factor (TNF-α) and expression of mRNA inhibitor of kappa B gene (IkB) nuclear factor kB (NF-kB) transcription were measured in the blood of the patients. Then, the experimental group was additionally prescribed to take resveratrol in a dose of 100 mg per day. In 2 months since the beginning of the therapy including resveratrol the patients underwent re-examination. The patients with CAD and AIT comorbidity were found to have increased levels of IL-1β and TNF-α, moderate increase in IL-10. The findings obtained did not significantly differ from the data from those in the control group. Expression of mRNA IkB was identical in both groups. Under the influence of resveratrol in the patients of the experimental group the levels IL-1β and TNF-α were significantly decreased, the level of IL-10 was unchanged, and the expression of mRNA IkBα decreased (p <0,05). All these findings of the control group stayed unchanged. The results of the study demonstrate the anti-inflammatory properties of resveratrol in cases of CAD and concomitant AIT that are associated with reduced transcriptional activity of NF-kB; Целта на проучването е да се изследва ефекта на ресвератрол върху маркери на хронично системно възпаление при пациенти с исхемична болест на сърцето (CHD) във връзка с автоимунно тиреоидит (тиреоидит на Хашимото). В изследването са участвали 85 пациенти с исхемична болест на сърцето: ангина, стабилно напрежение, FC II, 30 от които имаше допълнителна диагностика на тиреоидит (проучвателна група) на Хашимото, тиреоиден опция, 55 пациенти, направени от групата сравнение. След един месец за стабилизиране CHD терапия (бета-блокери, статини, аспирин), при пациенти определяне нивата на интерлевкин-1β кръвта (IL-1β), IL-10, тумор некрозен фактор (TNF-α) и експресия на ген мРНК инхибитор капа В (IkB ) ядрен транскрипционен фактор kB (NF-kB). След това групата на проучване допълнително назначен ресвератрол в доза от 100 мг на ден и 2 месеца са повтори проучвания. ИБС пациенти в комбинация с повишени нива на AIT намерени IL-1β, TNF-α, IL-умерено повишаване на 10, данните не са значително различни от резултатите на контролната група. Експресията на мРНК IkB е идентичен и в двете групи. Под влиянието на ресвератрол при пациенти с нива на изследването IL-1β, TNF-α значително намалява нивото на IL-10 не се променя експресията на мРНК IkBα намалява (р <0,05), в сравнение, тези показатели не са се променили група. Тези резултати показват, противовъзпалителните свойства на ресвератрол в комбинация с CHD AIT, свързани с намалена транскрипционна активност на NF-кВ.Документ Application of the principles of socionics in the work of the curator of the academic group(Полтавський державний медичний університет, 2023-10) Chekalina, N. I.; Чекаліна, Наталія ІгорівнаRelationships in an academic group are an essential component of the effectiveness of the educational process. Achieving psychological comfort and building friendly relations between students based on mutual respect and tolerance is also the responsibility of the academic group curator. One of the useful tools for implementing this task is socionics. The aim is to substantiate the feasibility of the practical application of socionics to create optimal relationships in the team and effective creative interaction in the educational process.Документ Bronchial obstruction as a factor of hemodynamic disturbances and electrical instability of the myocardium(Полтавський державний медичний університет, 2023-03-23) Olatunji, Victor Oluwatimilehin; Чекаліна, Наталія Ігорівна; Боряк, Віктор Петрович; Chekalina, N. I.; Boriak, V. P.Chronic obstructive pulmonary disease (COPD) is characterized by significant morbidity, which is contributed by risk factors of the modern environment, as well as high mortality due to respiratory failure and cardiovascular complications.Документ Changes in the indicators of stiffness and remodeling of magistral arteries in young patients at the early stage of essential hypertension under conditions of syntropy with obesity(Aluna Publishing, 2024) Ivanytska, T. A.; Kazakov, Y. M.; Petrov, Y. Y.; Burmak, Y. H.; Ivanytskyi, I. V.; Chekalina, N. I.; Shut, S. V.; Іваницька, Тетяна Анатоліївна; Казаков, Юрій Михайлович; Петров, Євген Євгенович; Бурмак, Юрій Григорович; Іваницький, Ігор Валерійович; Чекаліна, Наталія Ігорівна; Шуть, Світлана ВолодимирівнаThe study and analysis of indicators of remodeling and rigidity of magistral vessels in young essential hypertension patients with abdominal obesity and determination of the detected changes as a possible criterion for their remodeling.Документ Comparative evaluation of the effectiveness of resveratrol and quercetin in patients with coronary heart disease according to daily Holter monitoring of electrocardiogram(Видавнича група «Наукові перспективи», 2023) Chekalina, N. I.; Чекаліна, Наталія ІгорівнаThe leading cause of death in the world remains Coronary Heart Disease (CHD), despite the many treatments being developed. Therefore, the search for new effective methods of treating CHD is extremely relevant. One of the pathogenetic mechanisms of atherosclerosis progression, which is the morphological basis of CHD, is chronic systemic inflammation. Anti-inflammatory activity at different levels of pro-inflammatory signaling has polyphenols of plant origin, which determined the direction of our scientific search.Документ Gender and age aspects in the pathogenesis of bone mineral density disorders(Aluna Publishing, 2023-09) Chekalina, N. I.; Plaksa, V. M.; Kazakov, Yu. M.; Tribrat, T. A.; Shut, S. V.; Petrov, Ye. Ye.; Ivanytskay, T. A.; Чекаліна, Наталія Ігорівна; Плакса, Вікторія Михайлівна; Казаков, Юрій Михайлович; Трибрат, Тетяна Анатоліївна; Шуть, Світлана Володимирівна; Петров, Євген Євгенович; Іваницька, Тетяна АнатоліївнаOsteoporosis is a systemic progressive disease of the musculoskeletal system, caused by the loss of bone mass with the disrupted microarchitectonics of bone tissue, which leads to an increase in bone fragility and the risk of fractures. This disease is observed in all age groups, regardless of gender and race, but the highest prevalence is observed in Caucasians (white race), postmenopausal women, and the elderly. With an aging population and a decrease in life expectancy, osteoporosis is increasingly becoming a global epidemicДокумент Influence of postmenopause on the formation of chronic heart failure in women with arterial hypertension(Полтавський державний медичний університет м.Полтава, Україна, 2022-11-02) Казаков, Юрій Михайлович; Чекаліна, Наталія Ігорівна; Плакса, Вікторія Михайлівна; Kazakov, Y. M.; Chekalina, N. I.; Plaksa, V. M.Chronic heart failure (CHF) is the leading cause of disability and mortality in the population, the prevalence of which is steadily increasing. CHF is three times more common in late postmenopausal women. The purpose of the work is the analysis of modern scientific ideas about the pathogenesis of CHF with arterial hypertension (AH) in postmenopausal conditions. The review presents the main ideas about the pathogenesis of CHF, the influence of hypoestrogeny on the molecular mechanisms of the development of hypertension, endothelial dysfunction, myocardial fibrosis, myocardial remodeling, and osteodysmetabolism. The leading role of the activation of systemic inflammation in the development of CHF, their importance in the postmenopausal period is indicated. The pro-inflammatory molecular cascades involved in the formation of CHF in postmenopausal women are presented. Common links were found in the pathogenesis of hypertension, CHF and processes accompanying postmenopause. Potential early markers of the development of CHF are presented, and possible directions of therapeutic influence are indicated. The review systematizes modern ideas about the pathogenetic mechanisms of the development of CHF in postmenopausal women against the background of hypertension, which determines the prospects for solving the problematic issues of diagnosis and treatment of CHF.Документ Justification of increasing the blood flow velocity in the arteries of the thyroid gland in autoimmune thyroiditis as a reflection of endothelial changes due to inflammatory status(Bentham Science, 2019) Chekalina, N. I.; Burmak, Yu. H.; Petrov, Ye. Ye.; Borysova, Z. O.; Trybrat, T. A.; Shut, S. V.; Kazakov, Yu. M.; Чекаліна, Наталія Ігорівна; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Борисова, Зінаїда Олексіївна; Трибрат, Тетяна Анатоліївна; Шуть, Світлана Володимирівна; Казаков, Юрій МихайловичAbstract: Objective: The aim of the research was to determine the dependence of the blood flow velocity in the thyroid arteries in patients with autoimmune thyroiditis (AIT) on the presence of atherosclerotic carotid disease and the level of systemic blood pressure. Method: The research involved 20 patients with AIT in euthyroid state, 30 patients AIT in euthyroid state with stable coronary heart disease (CHD), 30 patients with stable CHD and 30 healthy individuals. Participants of the research were examined using ultrasound of carotid arteries and inferior thyroid arteries. Parameters of blood flow velocity were compared with the level of systemic blood pressure. Results: In AIT peak systolic velocity and resistance index in the inferior thyroid arteries were sig- nificantly higher than in healthy individuals and patients with CHD (p<0.05). In patients with CHD velocity parameters in carotid arteries were high, unlike in the healthy individuals and patients with AIT (p<0.05). In patients with AIT without CHD the atherosclerotic changes of carotid arteries were not found. Increased systemic blood pressure was noticed in all patients with CHD without significant differences between groups.Документ Markers of chronic systemic inflammation in patients with ischemic heart disease in combination with autoimmune thyroiditis influenced by resveratrol(2019) Ghalwash, Y.; Chekalina, N. I.; Kazakov, Yu. M.; Чекаліна, Наталія Ігорівна; Казаков, Юрій МихайловичДокумент Medical ethics and deontology in clinical practice(ТОВ НВП «Укрпромторгсервіс», 2015) Чекаліна, Наталія Ігорівна; Петров, Євген Євгенович; Chekalina, N. I.; Petrov, Ye. Ye.The textbook for students contains information about moral and ethical postulates in the relationship of the doctor and the patient, the solution of complex problems associated with moral choice, with respect of the patient’s rights, ethics in relationships in the medical team. A large section is devoted to medical errors, rules of clinical trials, issues of bioethics. The textbook for students is recommended for students who are learning English, but can also be useful to masters, residents, intern-doctors, trainees, medical practitioners and teachers; У навчальному посібнику наведені основні морально-етичні принципи професійної діяльності лікаря. Розглянуті моделі стосунків між лікарем та хворим, питання морального вибору, правової відповідальності лікаря. Велику увагу приділено правилам проведення медичних досліджень, біоетиці. Навчальний посібник призначений для самостійної підготовки до практичних занять, перш за все, студентів, які навчаються англійською мовою, проте може бути корисним магістрам, аспірантам, лікарям-інтернам, курсантам, практикуючим лікарям, викладачам.Документ Resveratrol more significantly than quercetin improves central hemodynamics in patients with ischemic heart disease(Полтавський державний медичний університет, 2023) Chekalina, N. I.; Чекаліна, Наталія ІгорівнаThe leading cause of death in the world remains coronary heart disease (IHD), despite the numerous treatments being developed. Therefore, the search for new effective methods of treatment of IHD is extremely relevant. One of the pathogenetic mechanisms for the progression of atherosclerosis, which is the morphological basis of coronary heart disease, is chronic systemic inflammation. Anti-inflammatory activity at different levels of proinflammatory signaling have polyphenols of plant origin. The purpose of the work is to assess the impact of polyphenols of respheratrol and quercetin on the indicators of central hemodynamics in patients with IHD.Документ The features of hepatic vascular blood flow under conditions of non-alcoholic fatty liver disease and its relation to chronic systemic inflammation(Українська медична стоматологічна академія, 2020) Olatunji, V. O.; Chekalina, N. I.; Manusha, Yu. I.; Чекаліна, Наталія Ігорівна; Мануша, Юлія ІванівнаДокумент The level of systemic inflammation and the state of central hemodynamics in patients with coronary heart disease(2018) Shut’, S. V.; Chekalina, N. I.; Trybrat, T. A.; Sakevych, V. D.; Boriak, V. P.; Шуть, Світлана Володимирівна; Чекаліна, Наталія Ігорівна; Трибрат, Тетяна Анатоліївна; Сакевич, Вікторія Дмитрівна; Боряк, Віктор ПетровичMaterials and methods. An open clinical trial was conducted. 230 patients with CHD were examined: stable angina pectoris, II FC, CH 0-I (119 men and 111 women aged 57 + 8.3 years) and 30 healthy subjects (control group). The criteria for inclusion in the study were the age of men and women (40-75 years), the presence of CHD: exertional angina of II FC in the absence of destabilization of the course for at least two months, the informed consent of the patient to participate in the study. The exclusion criteria were the presence of chronic heart failure higher than stage I, high blood pressure, complications of cardiac rhythm and conduction disorders, rheumatism, cancer, anemia, diabetes mellitus, renal and hepatic insufficiency. To achieve the aim of the research, patients’ blood was tested for levels of IL-1β and TNFα by the immune enzyme method; fibrinogen (FG) plasma levels – by weight method and echocardiography (echo) [7]. The global contractile ability of LV was estimated by the stroke volume (SV), the ejection fraction (EF), and the velocity of the blood flow (v) in the external path (EP) of the LV. The diastolic function of LV was investigated by recording the transmitral blood flow rates by the ratio of the velocities of the early (E) and late (L) diastolic filling of the LV (E / A), the delay time of early diastolic filling of the LV (DT) and the time of isovolumic LV relaxation (IVRT) [7].Документ The level of systemic inflammation and the state of central hemodynamics in patients with coronary heart disease with metabolic syndrome(2019) Shut’, S. V.; Chekalina, N. I.; Trybrat, T. A.; Sakevych, V. D.; Boriak, V. P.; Шуть, Світлана Володимирівна; Чекаліна, Наталія Ігорівна; Трибрат, Тетяна Анатоліївна; Сакевич, Вікторія Дмитрівна; Боряк, Віктор ПетровичMetabolic syndrome (MS) is one of the possible risk factors for coronary heart disease (CHD) [2,7]. Meanwhile, cardiovascular disease, and first and foremost, CHD, is one of the leading causes of death in developed countries of the world [1,8]. The prognosis for patients with coronary heart disease depends, predominantly, on the progression of coronary atherosclerosis (CA). Clinical significance of MS is determined by its important prognostic value in the development of cardiovascular diseases (CVD), and in particular, CHD, due to disturbance of the function of endothelial and smooth muscle cells of the vessels, local intravascular inflammation, increased platelets function and thrombosis [4,8]. The achievement of recent years is the concept as to the important role of chronic systemic inflammation (CSI) and insulin resistance (IR) in the pathogenesis of CA and CHD, which is especially relevant for MS patients [3, 8, 9].Документ The peculiarities of the changes of some cardiohemodynamic and microcirculatory indices in conditions of the comorbid course of essential hypertension(The New Armenian medical Journal., 2020) Burmak, Yu. G.; Petrov, Ye. Ye.; Kazakov, Yu. M.; Chekalina, N. I.; Treumova, S. I.; Tribrat, T. A.; Ivanitskaya, T. A.; Kozlenko, T. V.; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Казаков, Юрій Михайлович; Чекаліна, Наталія Ігорівна; Треумова, Світлана Іванівна; Трибрат, Тетяна Анатоліївна; Іваницька, Тетяна Анатоліївна; Козленко, Тетяна ВікторівнаThe peculiarities of cardiohemodynamics, microcirculation, and microvasculature are presented in the article; their correlation with significance of the oxidative stress, the level of antioxidative blood potential and endothelial function in the isolated course of essential hypertension and in conditions of its comorbidity with duodenal peptic ulcer was carried out. The structural-functional indices and parameters of cardiohemodynamics, indices of microcirculation and microvasculature, the content of the intermediate and the final products of lipid peroxidation in the blood, activity of enzymes of the antioxidant protection system and indices of endothelial function were estimated. It was established that the presence of the remodeling left ventricle (a significant increase of the left heart chambers, symmetrical myocardial hypertrophy) with the unchanged contractile function, and maximal intensity of both resistivity of the peripheral vascular system (р <0.001), and disorders of microcirculation and microvasculature on the perivascular, vascular, and intravascular levels (р <0.001) is typical of the patients with the comorbid course of essential hypertension. The next results showed that manifestations of oxidative stress were the most significant (the increase of diene conjugates and malondialdehyde content (p <0.001) among the patients with the combinative pathology. The index of the antioxidative ability of blood serum was low in these patients (p <0.001); besides, it had the negative correlation relationship with the index of the total changes of microhemocirculation and microvasculature (r = -0.467; p <0.05). At the same time the index of ristomycin- inducted platelet aggregation as reflection of the changed endothelial function and a marker of the thrombogenic risk was also the highest in case of the comorbid course of essential hypertension (p <0.001); besides, its positive correlation relationship with the index of the total changes of microhemocirculation and microvasculature (r = +0.465; p <0.05) was established.Документ The use of innovative training methods in teaching general practice – family medicine to students of the international faculty(Полтавський державний медичний університет, 2024) Shut, S. V.; Trybrat, T. A.; Chekalina, N. I.; Kazakov, Yu. M.; Myhal, V. M.; Шуть, Світлана Володимирівна; Трибрат, Тетяна Анатоліївна; Чекаліна, Наталія Ігорівна; Казаков, Юрій Михайлович; Мигаль, Вікторія МихайлівнаWhen studying general practice – family medicine at the department, innovative methods are used to ensure the improvement of the quality of the educational process and mastering of the necessary competencies by international students, enhancing their academic performance and results of the educational process.Документ Взаємозв’язки показників системного запалення, ліпідного спектру крові та структурно-функціонального стану серця при стабільній ішемічній хворобі серця(Українська медична стоматологічна академія, 2017) Чекаліна, Наталія Ігорівна; Чекалина, Наталья Игоревна; Chekalina, N. I.Мета: дослідити взаємозв’язки між показниками системного запалення, ліпідного спектра крові й структурно-функціонального стану серця у хворих на стабільну ішемічну хворобу серця (IXC). Об’єкт і методи. Проведено одномоментне відкрите клінічне дослідження за участю 30 пацієнтів з діагнозом IXC: стенокардія напруги стабільна, II ФК, CH 0-I. Вивчено кореляційні зв’язки між показниками ліпідного спектру крові, маркерами хронічного системного запалення, запальної активації ендотелію, показниками ішемії міокарда та параметрами центральної гемодинаміки. Проведено багатофакторний регресійний аналіз даних. Результати. Дані кореляційного аналізу дозволили виявити взаємозв’язок хронічного системного запалення, дисліпідемії та запальної активації ендотелію, негативний вплив зазначених чинників на систолічну та діастолічну функцію лівого шлуночка, їх взаємозв’язок з ішемією міокарда. За результатами регресійного аналізу визначено предиктори ішемії міокарда і порушень центральної гемодинаміки у пацієнтів зі стабільною IXC. Висновки. Отримані результати визначають хронічне системне запалення як провідний чинник розвитку і прогресування IXC, що є підґрунтям розробки патогенетично обґрунтованих лікувальних заходів.Документ Впровадження методів соціоніки у виховний процес(Івано-Франківський національний медичний університет, 2023-09) Чекаліна, Наталія Ігорівна; Казаков, Юрій Михайлович; Трибрат, Тетяна Анатоліївна; Шуть, Світлана Володимирівна; Мигаль, Вікторія Михайлівна; Chekalina, N. I.; Kazakov, Yu. M.; Trybrat, T. A.; Shut’, S.V.; Myhal, V. M.Психологічний комфорт у освітньому середовищі є запорукою успішної реалізації освітніх програм, розвитку творчих здібностей та формування професійних навичок у здобувачів освіти. Адаптація і побудова здорових відносин у новоствореному колективі має дуже важливе значення і лежить у площині компетентності всього педагогічного колективу. На даному етапі особливо важливою є роль куратора – мудрого наставника, порадника, який бере участь у вирішенні усіх нагальних питань, зокрема, у побудові гармонійних, доброзичливих, продуктивних стосунків у групі.Документ Гемодинамічні ефекти та особливості електричної активності серця при гострому міокардиті, асоційованому з коронавірусною інфекцією (COVID-19)(Полтавський державний медичний університет, 2021-10-08) Казаков, Юрій Михайлович; Чекаліна, Наталія Ігорівна; Борисова, Зінаїда Олексіївна; Кіруша, Ірина Сергіївна; Івашута, І. М.; Kazakov, Yu. M.; Chekalina, N. I.; Borysova, Z. O.; Kirusha, I. S.; Ivashuta, I. M.
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