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Документ Eponymous terms in the morphology of angioarchitectonics of the human head(Aluna Publishing, 2022) Hryn, Volodymyr; Yudina, Kseniia; Donchenko, Viktoriia; Zhamardiy, Valeriy; Horoshko, Viktoriia; Гринь, Володимир Григорович; Юдіна, Ксенія Євгеніївна; Донченко, Вікторія Іванівна; Жамардій, Валерій ОлександровичThe aim: The aim of the study is to investigate and describe eponymous terms of angioarchitectonics of the human head and to determine their features and possibilities of their functioning in modern medical terminology. Materials and methods: The work uses general philosophical and general scientific research methods: dialectical, historical-chronological, bibliographic-descriptive, analytical, etc. This bibliographic analysis is based on published peer-reviewed articles, books, textbooks, monographs. The search period covered the period from 2010 to 2021. Conclusions: The study of eponymous terms contributes to the disclosure of the evolution of clinical disciplines, the diagnostic process of thinking, as well as the formation of terminological competence in applicants for higher medical education, their mastery of the language of the specialty.Документ Experimental analysis of ways of viral infections into the human body(Aluna Publishing, 2022) Hryn, Volodymyr; Kostylenko, Yurij; Pinchuk, Viktoriia; Zhamardiy, Valeriy; Donchenko, Viktoriia; Honchar, Olha; Hordiienko, Oksana; Гринь, Володимир Григорович; Костиленко, Юрій Петрович; Пінчук, Вікторія Анатоліївна; Жамардій, Валерій Олександрович; Донченко, Вікторія Іванівна; Гончар, Ольга ОлександрівнаThe aim:The aim of the study is to experimentally test the process of viral infection and determine the ways of its penetration into the human body. Materials and methods: This experimental analysis is based on systematic research, published peer-reviewed articles, books, textbooks, monographs. It should also be noted that in order to identify some immunocompetent lymph node cells and the ability to visualize certain sites in the lymphoid nodes of Peyer’s patches, where the initial processes are presented below, we resorted to sampling anatomical material. The study involved 10 adult albino rats weighing 200.0 ± 20.0 g. The search period covered the period from 2010 to 2021, but the experimental analysis contains some valuable data from previous years, as these literature sources have significant scientific value. Results: According to immunohistochemical analysis of the epithelium associated with the dome of the lymph nodes of the small intestine of white rats, the bulk was B-lymphocytes (about 47%) and T-lymphocytes (about 35%), while plasma cells, macrophages and dendritic cells accounted for approximately 5% for each of them. Conclusions:Рrocess of development of viral infection can be represented in the form of the following targeted steps: 1) massive invasion of viruses into the body; 2) the pathway of viruses to the intended target (target cells) is carried out by the blood flow; 3) аchieving the target by viruses and their penetration into target cells. Іn the pathogenesis of viral diseases, the role is played by the preparedness of the particular body, which directly depends on the functional state of its immune system, which determines the possibility, severity and outcome of the disease.Документ General morphological characteristics of the results of experimental modeling of aseptic peritonitis(Annals of Anatomy, 2023) Hryn, Volodymyr; Kostylenko, Yuriy; Maksymenko, Oleksandr; Гринь, Володимир Григорович; Костиленко, Юрій Петрович; Максименко, Олександр СергійовичBackground: Aseptic peritonitis is a reaction of the local immune system aimed at rejection of a foreign body, which, having antigenic properties, does not (unlike a pathogen) counteract the immune system. The suture materials, namely catgut thread, used in intracavitary surgical operations possess xenogenic properties and can be used for antigenic stimulation of the immune system of the peritoneal cavity. Consequently, we decided to use a catgut suture for antigenic stimulation of the immune system of the peritoneal cavity and to study the morphological features of the results of experimental modeling of aseptic peritonitis in albino rats. Method: The study involved 15 Wistar albino male rats, weighing 286,13 ± 6,26 g. To study the dynamics of destructive changes made by the catgut implant in the peritoneal cavity of the experimental animals, the animals were assigned into three groups in accordance with the time interval of their euthanasia at 3, 7, and 14 days of the experiment. Results: After modeling an aseptic peritonitis, the investigation the abdominal cavity showed that in four out of five animals of the first group, that is, on day 3 of the experiment, the catgut implant had adhered to the greater omentum. The search for the fifth implant led to an unexpected discovery: we found it conjoined with the second derivative of the visceral peritoneum, similar in structure to the greater omentum, but related to the testes. On day 7, the implant embedded into the peritoneal cavity of the animals, had adhered to the serous formations of the testes in all five cases (100%, three of them – to the left epididymal omentum, and another two – to the right one). On day 14 (n = 5) it was found that in three cases it had adhered to the serous formations of the testes (60%, one of them to the left epididymal omentum, another two – to the right one) and in two cases it had adhered to the greater omentum (40%). Conclusion: During the experiment on implantation of a xenogenic substrate in the form of flat bundles made from the catgut thread into the peritoneal cavity of sexually mature male rats, it was found for the first time that their acceptors were not only the greater omentum, but also two derivatives of the peritoneum, homeomorphic to it and associated with the epididymides, which we reasonably called epididymal omenta and described in details.Документ Histological structure of the albino rat`s stomach(International Translational Medicine Congress Of Students And Young Physicians., Oscon, Croatia, 2022) Maryniak, Daria; Hryn, Volodymyr; Мариняк, Дар'я Костянтинівна; Гринь, Володимир ГригоровичДокумент Morphological aspects of the guinea pig submandibular salivary gland structure(Riga Stradins University Student Union, 2022) Maryniak, Daria; Zakaznykova, Ilona; Hryn, Volodymyr; Bilash, Valentyna; Мариняк, Дар'я Костянтинівна; Заказникова, Ілона Володимирівна; Гринь, Володимир Григорович; Білаш, Валентина ПавлівнаДокумент The issue of histological identification of m-cells in the peyer’s patches of albino rat small intestine(Wudawnictwo Aluna, 2022) Hryn, Volodymyr; Kostylenko, Yurij; Svintsytska, Natalia; Bilash, Valentyna; Lytovka, Volodymyr; Гринь, Володимир Григорович; Костиленко, Юрій Петрович; Свінцицька, Наталія Леонідівна; Білаш, Валентина Павлівна; Литовка, Володимир ВікторовичThe aim: Based on the above cytological signs of M-ceiis, we set the goal o f more detailed clarification o f some of their topological relationships with other enterocytes in the follicle-associated epithelium of Peyer's patches of albino rat small intestine. Materials and methods: 10 mature albino male rats weighted 200,0+20,0 g were involved into the study. Anatomical dissection with the sampling o f the sections of the small intestine containing Peyer's patches was carried out with subsequent embedment of the latter into paraffin blocks and making o f serial histological sections o f4 [im thick in the cross-section o f the small intestine, followed with hematoxylin-eosin staining. The specimens were studied and documented on the"Konus" light microscope equipped. Morphometric characteristics o f the specimen tissue structures were studied using the Sigeta X 1 mm/100 Div.x0.01 mm stage micrometer. Results: The findings of the study revealed enterocytes with phagocytic properties found in the lymphoid-associated epithelium of Peyer's patches o f the small intestine o f albino rats. Moreover, if they are clearly visualized at the light-optical level, then M-ceiis are poorly recognizable, which is consistent with a similar assessment made by other authors. Conclusions: Given this, the issue on the topology and functional purpose of M-ceiis remains uncertain to date and, thereby, the prospect o f further research is being outlined, which, in our opinion, can be successful using the method o f stereomorphological analysis. For this purpose, multilayer plastic reconstruction methods can be used for serial semi-thin sections o f Peyer's patches embedded in epoxy resin, according to the requirements of transmission electron microscopy.Документ The issue of histological identification of M-cells in the peyer’s patches of albino rat small intestine(Aluna Publishing, 2022) Hryn, Volodymyr; Kostylenko, Yurij; Svintsytska, Natalia; Bilash, Valentуna; Lytovka, Volodymyr; Гринь, Володимир Григорович; Костиленко, Юрій Петрович; Свінцицька, Наталія Леонідівна; Білаш, Валентина Павлівна; Литовка, Володимир ВікторовичThe aim: Based on the above cytological signs of M-cells, we set the goal of more detailed clarification of some of their topological relationships with other enterocytes in the follicle-associated epithelium of Peyer’s patches of albino rat small intestine. Materials and methods: 10 mature albino male rats weighted 200,0±20,0 g were involved into the study. Anatomical dissection with the sampling of the sections of the small intestine containing Peyer’s patches was carried out with subsequent embedment of the latter into paraffin blocks and making of serial histological sections of 4 μm thick in the cross-section of the small intestine, followed with hematoxylin-eosin staining. The specimens were studied and documented on the “Konus” light microscope equipped. Morphometric characteristics of the specimen tissue structures were studied using the Sigeta X 1 mm/100 Div.x0.01mm stage micrometer. Results: The findings of the study revealed enterocytes with phagocytic properties found in the lymphoid-associated epithelium of Peyer’s patches of the small intestine of albino rats. Moreover, if they are clearly visualized at the light-optical level, then M-cells are poorly recognizable, which is consistent with a similar assessment made by other authors. Conclusions: Given this, the issue on the topology and functional purpose of M-cells remains uncertain to date and, thereby, the prospect of further research is being outlined, which, in our opinion, can be successful using the method of stereomorphological analysis. For this purpose, multilayer plastic reconstruction methods can be used for serial semi-thin sections of Peyer’s patches embedded in epoxy resin, according to the requirements of transmission electron microscopy.