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    Comparative characteristics of the hemomicrocirculatory bed of the sciatic nerve trunk in rats with single administration of cryopreserved placenta and in acute aseptic inflammation
    (Буковинський державний медичний університет, 2020) Svyridyuk, R. V.; Shepitko, K. V.; Polyvyana, O. A.; Klypachenko, I. V.; Свиридюк, Роман Володимирович; Шепітько, Костянтин Володимирович; Полив'яна, Олександра Анатоліївна; Клипаченко, Інна Валеріївна; Свиридюк, Роман Владимирович; Шепитько, Константин Владимирович; Полывяная, Александра Анатольевна ; Клипаченко, Инна Валерьевна
    Objective. To study the response of the sciatic nerve trunk’s hemomicrocirculatory bed to a single administration of cryopreserved placenta and intraperitoneal administration of λ -carrageenan. Material and methods. An experimental study was performed on the sciatic nerve trunk of 100 sexually-mature rats. Histological research methods were used. It was established that when transplanting a cryopreserved placenta, all parts of the hemomicrocirculatory bed (HMCB) respond. Thus, the resistive part of the sciatic nerve trunk HMCB during cryopreserved placenta transplantation was characterized by a gradual increase in the mean diameters with the maximum value on the 5th-7th days and their complete recovery on the 10th day of the study. In the simulation of acute aseptic peritonitis there is a sharp decrease in diameters on the 2nd-3rd days, followed by their increase on the 5th-14th days and recovery on the 30th day. Results. In transplantation of cryopreserved placenta, the exchange link of the HMCB reacted significantly by increasing the mean diameter of the capillaries on the 5th day. In the simulation of acute aseptic peritonitis, the mean diameter of the capillaries increased on the 1st day and did not return to the control group limits on the 30th day of the study. Capacitive link responded to transplantation of cryopreserved placenta by an increase in diameter with the maximum value on the 5th day and recovery on the 10th day of the study (p <0.05). When simulating acute aseptic peritonitis, there is also an increase in diameters with the maximum value on the 7th day. On the 30th day of the study, the index value did not reach the limits of the control group. Conclusions. A single administration of cryopreserved placenta fragment causes shortterm changes in the hemomicrocirculatory bed with the maximum values on the 5th-7th days of the study, in contrast to a single injection of 5 mg of λ-carrageenan (Sigma - USA), which leads to reactive inflammation and lasts for over 30 days.