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Документ A case of combining follicular cysts of the lower jaw with eruption cysts in a child(Полтавський державний медичний університет, 2024) Tkachenko, P. I.; Bilokon, S. O.; Dolenko, O. B.; Starchenko, I. I. ; Korotych, N. N.; Popelo, Yu. V.; Lokhmatova, N. M.; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Доленко, Ольга Борисівна; Старченко, Іван Іванович; Коротич, Наталія Миколаївна; Попело, Юлія Вікторівна; Лохматова, Наталія МихайлівнаThe literature describes clinical cases combining follicular cysts of the jaws with other pathological processes. We performed a clinical and morphological analysis of a case of a combination of bilateral follicular cysts of the lower jaw with eruption cysts in a 7-year-old patient. The final clinical diagnosis is follicular cysts of the lower jaw from the 36th and 46th teeth and eruption cysts in the lateral parts of the lower jaw in the 36th and 46th teeth. Cystostomy was performed on the patient. At the same time, 75 and 85 teeth were left in the tooth rows, partially exposed crowns of 36 and 46 teeth. We did not find any peculiarities in the morphological picture of the postoperative material. At the same time, an eruption cyst that occurs above an erupting tooth does not lead to the appearance of a defect in the form of bone cavities, but the hydraulic pressure of its contents inhibits the tooth's eruption. However, it should not be forgotten that the variety of combinations of jaw cysts, particularly follicular cysts, with other pathology of the jaw bones requires a balanced, differentiated, individualized approach to diagnostic measures, treatment, and rehabilitation tactics for each patient. В літературі описані клінічні випадки сполучення фолікулярної кісти щелеп з іншими патологічними процесами. Нами проведено клініко-морфологічний аналіз випадку поєднання двосторонньої фолікулярної кісти нижньої щелепи з кістами прорізування у 7-річного пацієнта. Остаточний клінічний діагноз: фолікулярні кісти нижньої щелепи від 36 і 46 зубів, кісти прорізування в бокових відділах нижньої щелепи в ділянках 36 та 46 зубів. Пацієнту проведено цистотомію. При цьому 75 та 85 зуби залишені в зубних рядах; частково оголені коронки 36 і 46 зубів. Якихось особливостей морфологічної картини післяопераційного матеріалу ми не виявили. В той же час кіста прорізування, яка виникає над зубом, що прорізується, не призводить до виникнення дефекту у вигляді кісткових порожнин, однак гідравлічний тиск її вмісту гальмує прорізування зуба. Отже, не слід забувати, що розмаїття сполучень кіст щелеп, зокрема і фолікулярних, з іншою патологією щелепних кісток, вимагає виваженого, диференційованого, індивідуалізованого підходу при проведенні діагностичних заходів та виборі лікувально-реабілітаційної тактики для кожного пацієнта.Документ Adverse factors that can affect on the course of chronic parenchimatic parotitis in children(Wydawnictwo Aluna, 2020) Tkachenko, P. I.; Bilokon, S. O.; Popelo, Yu. V.; Lokhmatova, N. M. ; Dolenko, O. B.; Korotych, N. M.; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Попело, Юлія Вікторівна; Лохматова, Наталія Михайлівна; Доленко, Ольга Борисівна; Коротич, Наталія МиколаївнаThe aim: The study of the presence of disorders in the ante- and postnatal periods of development of children from 2 months to 15 years with chronic parenchimatic parotitis, which may affect its course. Materials and methods: It has been examined and treated 88 children, aged from 2 months to 15 years with chronic parenchimatic parotitis, and their mothers were interviewed, who indicated the pathological course of pregnancy, childbirth and indicated the type of breastfeeding babbies. The scope of the survey included general, additional methods, consultations by related specialists and statistical processing of results. Results: 88 children with the exacerbation of chronic parenchimatic parotitis were examined (42 – (47%) with active course and 46 – (53%) with inactive). The exacerbation occurred on the background of acute infectious processes or coincided with the exacerbation of one of the chronic diseases. The first manifestations occurred in spring (55%) and autumn (36%) periods, 44% of children were hospitalized with other diagnoses. The presence of pathological conditions during pregnancy and birth defects in their mothers were recorded more often 3,5 and 3,3 times, respectively, compared with control. 70% of children received mixed and artificial feeding and were more likely to become ill. Conclusions: The severity of clinical manifestations of inflammation and disorders of the general condition depended on the activity of the course of chronic parenchymatic parotitis and were more pronounced when active. During the remission period, no apparent clinical manifestations were detected in 72% of observations, however, in 28%, the identified signs indicated a latent course, which required additional treatment and rehabilitation measures.Документ Application of immunostimulants in combination with antioxidants in the comprehensive treatment of patients with odontogenic phlegmons(Poltava State Medical University, 2025-03-06) Ivanytska, O. S.; Tkachenko, P. I.; Bilash, S. M.; Voloshina, L. I.; Faustova, M. O.; Yaroshenko, I. R.; Haggag, Abdelrazik; Іваницька, Олена Сергіївна; Ткаченко, Павло Іванович; Білаш, Сергій Михайлович; Волошина, Людмила Іванівна; Фаустова, Марія Олексіївна; Ярошенко, І. Р.; Хаггаг, АбдельразікPurulent-inflammatory diseases of the maxillofacial region occupy a significant place in the clinic of surgical dentistry. The work is devoted to the study of the issue of stabilizing general immunity in odontogenic phlegmons by improving the standard protocol for providing surgical dental care, namely, including immunostimulants in combination with antioxidants in the composition of conservative therapy. Patients with odontogenic phlegmons (50 persons) were divided into 2 groups: the control group, whose treatment was carried out according to the standard protocol, the main group – patients, who were treated according to the protocol with an addition. The conservative treatment additionally included "Filgrastim" and "Cytoflavin". It was revealed that an improvement in the general condition of 22 patients of main group was noted on the 4th day after surgery, in 4 patients – on the 6th day, a decrease in pain syndrome was observed on average on the 5th day. In 19 patients, the absence of purulent exudate was noted on the 4th day, the appearance of granulations on the 6th, and complete epithelialization of the wound on the 7-8th day. The number of peripheral blood erythrocytes during the treatment tended to increase only in patients of the main group – on the 9th day the values approached the normal level and were significantly higher than those of patients of the control group. The level of hemoglobin concentration in the main group of patients also increased slightly. The tendency to normalization of the number of cellular elements in patients of the main group was noted already from the 5th day of the postoperative period. The results of the study demonstrated that the use of a protocol with an addition that includes immunostimulants and antioxidants in the comprehensive treatment of patients with odontogenic phlegmons allows achieving optimal functional and cosmetic results. Гнійно-запальні захворювання щелепно-лицевої ділянки займають значне місце в клініці хірургічної стоматології. Робота присвячена вивченню питання стабілізації загального імунітету при одонтогенних флегмонах шляхом удосконалення стандартного протоколу надання хірургічної стоматологічної допомоги, а саме, включення до складу консервативної терапії імуностимуляторів у поєднанні з антиоксидантами. Пацієнти з одонтогенними флегмонами (50 осіб) були розподілені на 2 групи: контрольну, лікування яких проводилося за стандартним протоколом, основну – пацієнти, які отримували лікування за протоколом з доповненням. Консервативне лікування додатково включало «Філграстим» та «Цитофлавін». Виявлено, що покращення загального стану у 22 пацієнтів основної групи відмічалося на 4-ту добу після операції, у 4 пацієнтів – на 6-ту добу, зменшення больового синдрому спостерігалося в середньому на 5-ту добу. У 19 пацієнтів відсутність гнійного ексудату відмічено на 4-ту добу, появу грануляцій – на 6-ту, повну епітелізацію рани – на 7-8-му добу. Кількість еритроцитів периферичної крові в процесі лікування мала тенденцію до збільшення лише у пацієнтів основної групи – на 9 добу показники наближалися до норми і були достовірно вищими, ніж у пацієнтів контрольної групи. Рівень концентрації гемоглобіну в основній групі пацієнтів також дещо підвищився. Тенденція до нормалізації кількості клітинних елементів у пацієнтів основної групи відзначалася вже з 5-го дня післяопераційного періоду. Результати дослідження продемонстрували, що використання в комплексному лікуванні пацієнтів з одонтогенними флегмонами протоколу з доповненням, що включає імуностимулятори та антиоксиданти, дозволяє досягти оптимальних функціональних та косметичних результатів.Документ Bitten wounds of the maxillofacial area in children(Wydawnictwo Aluna, 2020) Tkachenko, P. I.; Bilokon, S. O.; Dolenko, O. B.; Korotych, N. M.; Popelo, Yu. V.; Bilokon, N. P.; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Доленко, Ольга Борисівна; Коротич, Наталія Миколаївна; Попело, Юлія Вікторівна; Білоконь, Наталія ПавлівнаThe aim of the work is to determine the frequency, structure, features of clinical manifestations and treatment of bitten wounds of the face and neck in children of Poltava region. Materials and methods: It has been analyzed 91 histories of disease of thematic patients undergone treatment at the Surgical Department of Pediatric town clinical hospital of Poltava. Results: In the structure of traumatic injuries of maxillofacial area in children 5.3% were patients with bitten wounds of the face and neck. Among the injured were children of the age 7-12 years old (30.2%). In 74.7% of cases, the bites were complicated by acute inflammatory processes. Urban residents accounted for 71.8% of the total number of cases, while rural residents accounted for 28.2%. Boys were injured by 53.6% and girls by 46.4%. Sharps (74.5%), punctures (19.3%) and lacerations (6.2%) differed in form. The comprehensive treatment of patients with bitten maxillofacial area wounds was carried out according to the protocol of care. Conclusions: The clinical picture and severity of bitten wounds of maxillofacial area in children have individual features, which are largely due to topographic and anatomical localization of injuries. The choice of the optimal variant of primary surgical treatment of wounds and the amount of surgery should be determined individually depending on the severity of the injury, the time of injury. Special attention should be paid to normalization of psycho-emotional state of patients and prevention of scar formation.Документ Change in the dimensions and hemodynamics of the parotid salivary glands after the first course of polychemotherapy(Полтавський державний медичний університет, 2024) Tkachenko, P. I.; Popelo, Yu. V.; Lokhmatova, N. M.; Bilokon, S. O.; Dolenko, O. B.; Korotych, N. M.; Okulov, Yu. V.; Ткаченко, Павло Іванович; Попело, Юлія Вікторівна; Лохматова, Наталія Михайлівна; Білоконь, Сергій Олександрович; Доленко, Ольга Борисівна; Коротич, Наталія Миколаївна; Окулов, Юрій ВалерійовичToday, the algorithm for carrying out diagnostic and planning and control of the treatment and preventive measures involves the use of ultrasound examination with doppler scanning of intra-organ blood vessels.Документ Clinical and morphological features of follicular cysts of jaw in children(2023) Tkachenko, P. I.; Bilokon, S. O.; Dolenko, O. B.; Lokhmatova, N. M.; Popelo, Yu. V.; Korotych, N. M.; Bilokon, Yu. S.; Lachabi, Reda; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Доленко, Ольга Борисівна; Лохматова, Наталія Михайлівна; Попело, Юлія Вікторівна; Коротич, Наталія Миколаївна; Білоконь, Юлія СергіївнаДокумент Clinical characteristic of different types of conservative treatment os pathological scars of head and neck(Полтавський державний медичний університет, 2023) Tkachenko, P. I.; Lokes, K. P.; Bondarenko, V. V.; Bilokon, S. O.; Ivanytska, O. S.; Rezvina, K. Y.; Ivanicky, I. O.; Ткаченко, Павло Іванович; Локес, Катерина Петрівна; Бондаренко, Валерій Володимирович; Білоконь, Сергій Олександрович; Іваницька, Олена Сергіївна; Резвіна, Катерина Юріївна; Іваницький, Ігор ОлексійовичThere are a lot of different types of conservative and surgical treatment of pathological scars. The purpose of study was to analyze the result of using of ultraphonophoresis of Contractubex and electrophoresis with lidase in case of conservative treatment of scars of maxillofacial region. The study involved 40 patients of the Department of Maxillofacial Surgery of the Poltava Regional Clinical Hospital with pathological scars of maxillofacial localization. All patients were divided into two clinical groups of 20 people each. Patients of the first clinical group were administered the Contractubex daily using ultraphonophoresis. Patients of the second clinical group underwent electrophoresis with lidase. The nature of the scars was assessed by four clinical signs (type, texture, color and sensitivity), expressed on a 4-point scale. Both methods of conservative treatment of maxillofacial scars have a predominant effect on subjective indicators, such as itching. A more pronounced effect of treatment was noted after the use of ultraphonophoresis of contractubex, in this group of patients there was also a significant improvement in such an objective clinical indicator as the color of the scar. The use of lidase electrophoresis led only to a reliable improvement in subjective feelings (P4), in the absence of such in relation to three objective indicators. Thus, the investigated methods of conservative treatment mainly affect the subjective characteristics of scar tissue. Moreover, the use of contractubex ultraphonophoresis has a more pronounced effect than the use of lidase electrophoresis.Документ Clinical-morphological characteristics and peculiarities of treatment of paraururicular fistulas in children(Wydawnictwo Aluna, 2020) Tkachenko, P. I.; Starchenko, I. I.; Bilokon, S. O.; Popelo, Yu. V.; Lokhmatova, N. M.; Dolenko, O. B.; Korotych, N. M.; Hohol, A. M.; Bilokon, N. P.; Ткаченко, Павло Іванович; Старченко, Іван Іванович; Білоконь, Сергій Олександрович; Попело, Юлія Вікторівна; Лохматова, Наталія Михайлівна; Доленко, Ольга Борисівна; Коротич, Наталія Миколаївна; Гоголь, Андрій Михайлович; Білоконь, Наталія ПавлівнаThe aim: Determining the frequency of occurrence of paraauricular fistula in children and comparing the results of their own experience regarding their clinical manifestations, treatment principles and morphological features with existing scientific data. Materials and methods: The results of a comprehensive examination and surgical treatment of 25 children with paraauricular fistulas. Results: Most often, para-auricular fistula was observed in infants 22 – (88%). In 18 persons (72%), they were unilateral, in 10 – (40%) hereditary. In 8 – (32%), fistula was diagnosed immediately after birth. In 17 – (68%) the pathology was not clinically manifested, but was an accidental finding during the next medical examination. Morphological research has shown that congenital paraauricular fistula is a formed canal intimately associated with the epithelium and cartilage, and the presence of epithelial lining on the fistula wall with constant support of the inflammatory process makes it impossible to heal even against the background of multicomponent treatment. Conclusions: Due to the topographic-anatomical localization, features of the clinic of the born fistula, surgical treatment does not always allow to achieve the desired results, and requires repeated interventions during recurrence. It is possible to prevent recurrence by the extensive use of additional diagnostic manipulДокумент Clinicomorphological characteristics of the wound process at the early postoperative period after radical uranostaphyloplasty(Українська медична стоматологічна академія, 2019) Tkachenko, P. I.; Dolenko, O. B. ; Lokhmatova, N. M.; Bilokon, S. O.; Dobroskok, V. O.; Ткаченко, Павло Іванович; Доленко, Ольга Борисівна; Лохматова, Наталія Михайлівна; Білоконь, Сергій Олександрович; Доброскок, Віталіна Олексіївна; Ткаченко, Павел Иванович; Доленко, Ольга Борисовна; Лохматова, Наталия Михайловна; Белоконь, Сергей Александрович; Доброскок, Виталина АлексеевнаThe purpose of the paper was to study the clinical situation and the morphological structure of the biopsy material of the hard palate mucoperiosteal grafts in children with the congenital cleft palate before surgery and at the early postoperative period after radical uranostaphyloplasty. The study of clinical characteristics and general somatic state of children with this pathology before operative intervention enables to reveal the marked anatomical and functional disorders. The study of the wound process at the early postoperative period after radical uranostaphyloplasty with the help of morphological structure of the biopsy material of the hard palate mucoperiosteal grafts enables to predict the degree of probability of the formation of dense scar and make individual plan of treatment-and-prophylactic and rehabilitation measures for this category of patients. Метою роботи було вивчення клінічної ситуації та морфологічної структури біоптатів слизово-окісних клаптів піднебіння у дітей з його вродженими незрощеннями до оперативного втручання та в ранньому післяопераційному періоді після радикальної ураностафілопластики. Дослідження клінічної характеристики та загально соматичного стану у дітей з цією патологією до оперативного втручання дозволило виявити у них виражені анатомічні та функціональні порушення. Вивчення ранового процесу в ранньому післяопераційному періоді після радикальної ураностафілопластики за допомогою морфологічної структури біоптатів слизово-окісних клаптів піднебіння дає змогу спрогнозувати ступінь вірогідності формування щільного рубця, та скласти індивідуальний план лікувально-профілактичних і реабілітаційних заходів для цієї категорії хворих.Целью работы было изучение клинической ситуации и морфологической структуры биоптатов слизистонадкостничных лоскутов неба у детей с его врожденными несращениями до оперативного вмешательства и в раннем послеоперационном периоде после радикальной ураностафилопластики. Исследование клинической характеристики и общего соматического состояния у детей с этой патологией до оперативного вмешательства позволило выявить у них выраженые анатомические и функциональные нарушения. Изучение раневого процесса в раннем послеоперационном периоде после радикальной ураностафилопластики с помощью морфологической структуры биоптатов слизисто-надкостничных лоскутов неба позволяет спрогнозировать степень достоверности формирования плотного рубца, и составить индивидуальный план лечебно-профилактических и реабилитационных мероприятий для этой категории больных.Документ Diagnostic information of computed tomography of the upper jaw in patients required implant rehabilitation(Wydawnictwo Aluna, 2018) Tkachenko, P. I.; Pankevych, A. I.; Kolisnyk, I. A.; Gogol, A. M.; Ткаченко, Павло Іванович; Панькевич, Артур Іванович; Колісник, Інна Анатоліївна; Гоголь, Андрій МихайловичIntroduction: Dental implantation in conditions of bone deficiency in the loss of lateral group of teeth of the upper jaw is impossible without the maxillary sinus floor augmentation. Preparation for surgical intervention requires a thorough assessment of the anatomical features of the sinus, relationship between the sinus and adjacent teeth, detection of foci of chronic infection of the Schneiderian membrane. In the complex of the objective methods of investigation, computed tomography is the most informative approach to study the state of the bone and soft tissue structure of the sinus. The aim of the paper is to evaluate the state of the bone structures and maxillary sinus membrane to determine the technique for selection the optimum alternative for management of patients, who required sinus lift, based on the computed tomography. Materials and methods: Computed tomographic examination of 206 patients with bounded and free-end edentulous spaces in the lateral area of the upper jaw was carried out over a period of 2010-2017 to evaluate the appropriateness of sinus lift approach and selection of its technique. The state of the bone tissue and presence of the auxiliary septa, intranasal structures, including ostiomeatal complex, presence of edema and exudates, lesions of the mucosa, as well as the state of ostium maxillaris has been estimated. Results: In the projection of the maxillary sinus the thickness of the bone tissue ranged within 1 mm to 10,5 mm; the density of bone tissues was of the D3-D4 type. Inflammatory events were detected in 60,1%, including: thickening of the mucous membrane on the right and on the left (40,6% and 41,1%, respectively), the total edema (8,6% and 9,7%, respectively). Bilateral thickening was found in 38,8%, and bilateral total edema in 28,0% of cases. Remnants of the filling material were found in 1,4% of sinuses on the right and in 2,8% on the left. Bone septum was visualized on the right in 18,8%, and in 17,4% on the left, bilateral in the 31,8%. Cystic masses were detected on the right in 4,2% of cases and in 6,2% on the left, bilateral in 16,7%. Conclusions: Computed tomographic examination provides thorough evaluation of the parameters of the bone tissues, state of mucous membrane and peculiarities of architectonics of maxillary sinuses at the pre-implantation stage.Документ Differential-diagnostic informativeness of the morphological and immunohistochemical study of parotid salivary gland cysts(Aluna Publishing, 2023-09) Tkachenko, P. I. ; Rezvina, K. Yu.; Bilokon, S. O.; Lokhmatova, N. M.; Dolenko, O. B.; Popelo, Yu. V.; Shvets, A. I.; Ткаченко, Павло Іванович; Резвіна, Катерина Юріївна; Білоконь, Сергій Олександрович; Лохматова, Наталія Михайлівна; Доленко, Ольга Борисівна; Попело, Юлія Вікторівна; Швець, Анатолій ІвановичThe aim: To conduct a general analysis of the results of the study of the morphological and immunohistochemical structure of cysts of the parotid salivary glands. Materials and methods: Our study is based on the application of generally accepted, additional and special methods of examination, which concerns 21 patients who underwent surgical intervention to remove cystic formations of the parotid salivary gland. Results: It was established that there are 2-3 HLA-DR+ cells per 100 epithelial cells located in the basal and subbasal layers in the form of their continuous ribbon and their moderate infiltration of tissues within the acinar epithelium. In the epithelium, CD3+ cells were also detected in the number of 1 to 7 per 100 epitheliocytes and they were the most numerous, along with HLA-DR+ cells. Instead, the presence of CD4+ and CD20+ cells was not detected in the epithelium, unlike the subepithelial layer, where they occupied significant areas. In turn, the infiltration of CD8+ cells of the epithelial layer was established in the amount from 1 to 7 per 100 epitheliocytes. A moderate number of them was also determined subepithelially, and they were single directly in the cyst wall. Conclusions: Immunohistochemical study of the structural components of cystic formations is this is the direct way to establish the nature of the redistribution of immune cells in it, which is very important when conducting differential diagnosis in difficult and doubtful cases.Документ Difficulties of the diagnosis and treatment of dermoid and epidermoid cysts of the maxillofacial area and the neck among children(Національний медичний університет імені О. О. Богомольця, 2020) Tkachenko, P. I.; Bilokon, S. O.; Bilokon, Y. S.; Shevchuk, A. R.; Fleischhauer, S.; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Білоконь, Юлія СергіївнаIt is generally accepted that dermoid and epidermoid cysts are the result of malformation of the ectoderm. The asymptomatic course, absence of pathognomonic symptoms and similarity of clinical manifestations at separate stages of growth, despite nosological form and place of occurrence, give this pathology of particular relevance in the practice of pediatric maxillofacial surgery. However, if there are no significant issues regarding the etiology and pathogenesis of dermoids and epidermoids, there is a problem of constant monitoring of their prevalence and structure for the formation of administrative organizational measures for the planning of specialized care for this category of patients. Special attention should also be given to the development of new, minimally invasive surgical interventions, given the increasing aesthetic demands and requirements of patients. The aim of the study is to study in a comparative aspect their own experience on the clinical and morphological features and principles of treatment of dermoid and epidermoid cysts of the maxillofacial area and neck in children with the results of scientific studies, covered in literature. A thorough analysis of fundamental scientific works and publications in periodicals devoted to the scientific development of various directions in relation to these issues is carried out. The clinical section of the work concerns 15 children with dermoids and 8 children with epidermoids who have been treated for 8 years in the surgical ward of the children’s clinical hospital in Poltava. General clinical, additional, and specific examination methods were used to establish clinical diagnosis, including diagnostic puncture, ultrasound, and MRI examination, which was performed in complex and questionable cases. If necessary, the patients were consulted by doctors of related specialties. The microscopic structure of the postoperative material was studied on preparations made by conventional methods. An objective study found that the clinical picture of the dermoid and epidermoid cysts is similar, differing only in slight subjective sensations on palpation. Comparison of clinical diagnosis and results of postoperative morphological verification of removed soft tissue bones showed that in 23.9% of patients the clinical diagnosis did not coincide with pathohistological. The difference in dermoids was the largest (75.0%), which confirms the need for expanded use of additional examination methods both at the prehospital stage and under inpatient conditions immediately before surgery. In general, the obtained morphological picture of the postoperative material coincided with the literature data on the classical structure of the dermoid and epidermoid cysts of the soft tissues of the maxillofacial area. Thus, the dermoid and epidermoid cysts of the maxillofacial area in children, having a dysontogenic origin, are most often diagnosed at younger and older school age. Despite their classic clinical picture, a considerable number of discrepancies between clinical and pathohistological diagnoses are traced, requiring a careful examination at both the hospital and hospital stages using modern, informative supplementary and special methods of investigation in complex and doubtful cases of cases and complex cases. These materials may be the basis for further in-depth scientific studies on immunohistochemical structural features dermoids and epidermoids to determine immunocompetence layers cystic membranes and determine their probable role in causing acute inflammation depending on the type of formation.Документ Difficulties of the diagnosis and treatment of traumatic and aneurysmal cysts of the jaws(Національний медичний університет імені О. О. Богомольця, 2020) Tkachenko, P. I.; Bilokon, S. O.; Shevchuk, A. R.; Bilokon, Y. S.; Fleischhauer, S.; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Білоконь, Юлія СергіївнаThe great diversity of the jaw cysts makes the issues of their diagnosis, differential diagnosis and treatment quite important, always requiring individual approach, given the features of each clinical case. Although the jaw cysts were first mentioned by Scultetus in 1654, the researchers still have different views on the semiotics and group belonging of individual nosological forms in the classifications and, consequently, on120 the choice of treatment method, prevention of possible complications and recurrences, and making prognosis. Asymptomatic clinical course and absence of characteristic clear clinical manifestations of the jaw cysts, similarity of their signs at separate stages of the development, regardless the nosological form and site of origin, make this pathology relevant in the practice of maxillofacial surgery. Traumatic and aneurysmal pseudocysts are common in the nomenclature of tumor-like formations of the jaws. The paper is concerned the etiology and pathogenesis, clinical morphological features and modes of treatment of traumatic and aneurysmal jaw cysts, based on the generalization of the findings of the scientific researches, to emphasize the above nosological forms to the medical community. The study encompassed the thorough analysis of the fundamental scientific works and publications in periodicals on above issues. The clinical part of the study concerned a comprehensive examination of 46 children with traumatic and aneurysmal jaw cysts who received treatment at the surgical unit of the Poltava Municipal Children’s Clinical Hospital during the period of 5 years. In addition, 8 adult patients with traumatic cysts were examined and received outpatient treatment at the Department’s clinic. Common clinical and additional examination methods, diagnostic puncture, EOD, radiography, CT and MRI were used to make the clinical diagnosis in serious cases. The microscopic structure of the specimens made from the postoperative material using conventional techniques, was studied. During 2014-2019, 46 children with neodontogenic jaw cysts (NJC) were treated at the Department of Children’s Oral Surgery, including 24 patients (52.2%) with traumatic cysts (TC) and 15 patients (32.6%) with aneurysmal cysts (AC). That is, TC and AC were accounted for 39 cases (84.8%) of NJC. At the same time, if the general age of patients with NJC ranged from 5 to 15 years, then TC and AC were most common in children aged 10-15 years, which is in concordance with the data of other researchers, who mark their highest percentage in puberty. 25 (64,1%) boys and 14 girls (35.9%) have been involved into study. Generalized statistical analysis revealed that traumatic cysts accounted for 52.2% of children, 32.6% for aneurysmal, 15.2% for other types of non-odontogenic jaw cysts. Among patients, boys predominated, and even121 trauma in the past medical history does not always correspond and confirm the type of cystic formation. The presented material suggests a rather conditional diagnostic «boundary» between traumatic and aneurysmal cysts, when, in fact, the main differential diagnostic criterion is a carefully gathered anamnesis, even at the prehospital stage. The given material can be the basis for further in-depth scientific and practical studies on the study of immunohistochemical structural features of traumatic and aneurysmal jaw cysts.Документ Effectiveness of preventive measures in the inactive course of chronic parenchymatic mumps in children(Aluna Publishing, 2023) Tkachenko, P. I.; Bilokon, S. O.; Lokhmatova, N. M.; Dolenko, O. B.; Popelo, Yu. V.; Korotych, N. M.; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Лохматова, Наталія Михайлівна; Доленко, Ольга Борисівна; Попело, Юлія Вікторівна; Коротич, Наталія МиколаївнаAim: To study the effectiveness of preventive measures in the inactive course of chronic parenchymal mumps in remission. Materials and Methods: In the dynamics of precautionary measures, aimed at preventing of exacerbation of chronic processes in the parotid glands, were examined 29 children aged from 2 months to 16 years with inactive mumps in remission and 10 control persons aged from 7 to 15 years. Results: According to the assessment of the cellular composition of parotid secretion before anti-relapse measures in 9 patients out of 19, it was possible to detect the presence of latent chronic inflammation in symmetrical glands in the absence of classical clinical symptoms and clear secretion. After the completion of the treatment-and-prophylactic complex, the number of inflammatory cells and the degree of its contamination with microorganisms decreased significantly. Conclusions: The study of the composition of parotid secretion with taking into account of the results of ultrasound examination and sialography in the dynamic monitoring of chronic parenchymal mumps indicate its high diagnostic informativeness and allows a rational approach to planning preventive measures. The methodological approach, which was developed and tested by us and which was used in the active course of mumps, showed its high efficiency and inactive form of the disease, for the first year of observation the number of exacerbations decreased by 10 times, and for 5 years term- by 16 times, which allowed to prolong the remission period and improve the rheological properties of parotid secretion.Документ Effectiveness оf correction of psycho-emotional stress in children with traumatic injury to soft tissues and facial bones(Aluna Publishing, 2021) Tkachenko, P. I.; Lokhmatova, N. M.; Bilokon, S. O.; Popelo, Yu. V.; Dolenko, O. B.; Korotych, N. M.; Pankevych, A. I.; Kolisnyk, I. A.; Ткаченко, Павло Іванович; Лохматова, Наталія Михайлівна; Білоконь, Сергій Олександрович; Попело, Юлія Вікторівна; Доленко, Ольга Вячеславівна; Коротич, Наталія Миколаївна; Панькевич, Артур Іванович; Колісник, Інна АнатоліївнаThe aim: To study the effectiveness of correction of psycho-emotional stress in children with traumatic injuries of the tissues of the maxillofacial area. Materials and methods: A comprehensive examination and treatment of 58 children aged 3 to 15 years with traumatic injuries of the maxillofacial area were conducted during the period of 5 years. This applied to soft tissue injuries in 51.7% of cases and in 48.3% - to facial bone injuries. To test the severity of the psycho-emotional state, two homogeneous groups were formed in a total of 41 persons of primary and secondary school age. Results: A comparison of the results of our previous studies, which concerned only the fact of psychological testing and changes in vegetative balance in children with traumatic injuries with a group of patients who underwent comprehensive treatment with additional involvement of targeted psychoneuropharmacological correction allowed to establish, that this approach made it possible to eliminate vegetative disorders and reduce the degree of stress in them for 9-10 days from the time of hospitalization. Conclusions: In children with traumatic injuries of soft tissues and bones of the face, dysregulation of vegetative function and intensity of compensatory-adaptive mechanisms of the body with the predominance of the central mechanism of regulation. With the additional involvement of the drug “Noofen®” in the complex of therapeutic measures, it allows to stabilize their psychological state, which indicates its effectiveness.Документ Features of the course, clinical and morphological characteristics of ameloblastoma and fibrous dysplasia in children(Полтавський державний медичний університет, 2021) Ткаченко, Павло Іванович; Старченко, Іван Іванович; Білоконь, Сергій Олександрович; Резвіна, Катерина Юріївна; Попело, Юлія Вікторівна; Доленко, Ольга Борисівна; Лохматова, Наталія Михайлівна; Коротич, Наталія Миколаївна; Білоконь, Наталія Павлівна; Tkachenko, P. I.; Starchenko, I. I.; Bilokon, S. O.; Rezvina, K. Yu.; Popelo, Yu. V.; Dolenko, O. B.; Lokhmatova, N. M.; Korotych, N. N.; Bilokon, N. P.У статті висвітлені особливості клінічного перебігу та морфологічних характеристик, діагностичних заходів і лікування дітей з амелобластомою та фіброзною дисплазією щелепних кісток. Відсутність чітких клінічних проявів, подібність симптоматики і характер перебігу амелобластоми та фіброзної дисплазії, що є притаманним для усіх доброякісних пухлин щелепно-лицевої ділянки у дітей, обумовлюють значний відсоток діагностичних помилок, роблячи питання їх диференційної діагностики доволі актуальним для хірургічної стоматології і щелепно-лицевої хірургії.Документ Frequency and structure of benign soft tissue formations in the maxillofacial area(Українська медична стоматологічна академія, 2020) Ткаченко, Павло Іванович; Резвіна, Катерина Юріївна; Швець, Анатолій Іванович; Попело, Юлія Вікторівна; Ткаченко, Павел Иванович; Резвина, Екатерина Юрьевна; Швец, Анатолий Иванович; Попело, Юлия Викторовна; Tkachenko, P. I.; Rezvina, K. Yu.; Shvets, A. I.; Popelo, Yu. V.The article considered our own observation results and retrospective analysis of archival material of the Maxillofacial Department of M.V. Sklifosovsky Poltava Regional Clinical Hospital and Surgical Department of the Poltava City Children's Clinical Hospital from 2008 to 2018. It was found that among adults the number of patients with benign soft tissue formations of the face and neck is 4.9%, and in children – 7.8% of the total number of inpatients. Most of them were bronchiogenic cysts of the lateral part of the neck (152 – 26.3%) and atheromatous plaques (147 – 25.4%). They mostly occured at the age of 22 to 60 years, men suffered more often (205 - 35.5%). The largest number of discrepancies in the diagnosis at the prehospital phase were patients with epidermal cysts – 38 (7.9%). As for pediatric population, their number was 7.8% of the total number of inpatients. Neoplasms of dysontogenetic origin predominate, among which the most common were dermoid cysts – 92 patients (32.4%) and haemangiomas– 74 patients (26%). Less common were ranulae – 36 cases (12.7%), bronchiogenic cyst – 17 cases (6%) and atheromatous plaque – 16 cases (5.6%). They were found more often in the nursery age – from 1 to 3 years.Документ Frequency, structure and clinical manifestations of thermal burns of the jaw-facial area in children(Wydawnictwo Aluna, 2021) Tkachenko, P. I.; Bilokon, S. O.; Lokhmatova, N. M.; Dolenko, O. B.; Korotych, N. M.; Popelo, Yu. V.; Rezvina, K. Yu.; Hohol, A. M.; Ткаченко, Павло Іванович; Білоконь, Сергій Олександрович; Лохматова, Наталія Михайлівна; Доленко, Ольга Борисівна; Коротич, Наталія Миколаївна; Попело, Юлія Вікторівна; Резвіна, Катерина Юріївна; Гоголь, Андрій МихайловичThe aim: To establish the frequency, structure and features of the clinical course of facial and neck burns in children. Materials and methods: During 5 years, 78 patients aged from 6 months to 15 years with isolated burns of the face and neck and in combination with lesions of other anatomical areas were treated. In the dynamics of observation of patients were used classical methods of examination, and in their treatment we followed the protocol of medical care for this category of patients. Results: Thermal injuries of the face and neck accounted for 12.6% of the total number of patients with burns. Their isolated lesion was 26.9%, and in combination with other areas it was 73.1%. The most frequently affected were children of nursery, primary school and preschool age, with a predominance of rural residents (52.6%), mostly boys (78.0%). Anesthesia support had to be used in the treatment of 24 patients (30,8%). The features and nature of the burns depended on the relief of the face and the most damaged are its protruding parts. Conclusions: Open flames were the most common cause of thermal burns of the face and neck in children, and the lesions were combined with burns to the chest, abdomen, and limbs. The main reasons were reckless behavior of children, their increased mobility and lack of care for their relatives. It should be noted that in 3.8% of victims there was a delay in mental and physical development.Документ Impact of polychemotherapy on the oral soft tissues in children with malignant abdominal tumors(Wydawnictwo Aluna, 2019) Popelo, Yu. V.; Tkachenko, P. I.; Bilokon, S. O.; Попело, Юлія Вікторівна; Ткаченко, Павло Іванович; Білоконь, Сергій ОлександровичIntroduction: According to modern standards of treatment of malignant neoplasms conducting polychemotherapy requires up to 90% of cancer patients. However, in addition to the expected cytotoxic effects, it is accompanied by disorders in dental health in the vast majority of patients. The aim: To study the effect of cytostatics on soft tissues of the oral cavity in children with malignant tumors of the abdominal cavity. Materials and methods: Material for writing this scientific work served as a synthesis of results for 25 people aged 7 to 15 years with malignant tumors of the abdominal cavity, in which a comprehensive oral examination was performed to determine the manifestations of dental toxicity cytostatics. Results: At the end of the first course of chemotherapy, all patients had dry redness of the lips, 20 - (80,0%) with eruptions, in 18 - (20,0%) erosion. The Green-Vermillion, PMA, and PBI indices grew by 1,8; 7 and 3,3 times respectively. In cytograms with buccal epithelium an increase in the number of cells of polymorphic sizes and forms with signs of gidropic dystrophy was found. The nuclear-cytoplasmic ratio decreased by 1,4 times compared with the primary examination. Conclusions: This situation creates the preconditions for the development of inflammatory process in the tissues of the oral cavity and requires the use in this category of patients of a substantiated pathogenetic correction of existing disorders.Документ Impregnation of oral mucosa over impacted teeth by subpopulations of macrophages M1 and M2(Aluna Publishing, 2021) Tkachenko, P. I.; Dmytrenko, M. І.; Cholovskyi, M. О.; Korovina, L. D.; Mamontova, T. V.; Ткаченко, Павло Іванович; Дмитренко, Марина Іванівна; Чоловський, Микола Олександрович; Коровіна, Лідія Дмитрівна; Мамонтова, Тетяна ВасилівнаThe aim: Of the study is to research quantitative parameters of mucous membrane macrophages populations M1 (CD68+) and M2 (CD163+) over vestibularly and palatally impacted teeth. Materials and methods: A group of 21 people aged from 10 to 16 years was formed to conduct the research. Clinical situation according to diagnostic criteria was identical in all the patients. The group was divided into two groups - control and experimental, which in their turn were fragmented into two subgroups. Immunohistochemical studies of mucosal biopsies were performed in accordance with the recommendations for selection. Results: Study of ratio of CD68+/CD163+ cells revealed imbalance in individuals with vestibularly impacted teeth due to higher infiltration density of CD163+ (p<0,05), compared to CD68+ of control group. In individuals with palatally impacted teeth, ratio of CD68+/CD163+ increased 3,6 times, as well as compared with control group, but due increased infiltration density of CD68+. Conclusions: In the epithelium of oral mucosa located over impacted teeth, both on vestibular and palatal surface, number of CD 68+ and CD163+ cells had no significant differences compared to control group. In biopsies of the lamina propria of mucosa over vestibularly impacted teeth, the ratio M1/M2=0,91±0,11 (p<0,05) decreases, with predominance of macrophages CD163+ subpopulation activity, and over palatally impacted teeth balance of M1/ M2 macrophages elevated (M1/M2= 2,10 ± 0,32, p<0,05), due to increased infiltration density of CD68+.