Світ медицини та біології, 2021, № 1 (75)

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The effect of doxorubicin-induced oxidative stress on resistance of intestinal mucosa
(Українська медична стоматологічна академія, 2021) Skrypnyk, R. І.; Maslova, G. S.; Скрипник, Роман Ігорович; Маслова, Ганна Сергіївна
The paper presents the findings of our own studies on the evaluation of the effect of anthracycline-induced oxidative stress on the level of N-acetylneuraminic acid and the state of the processes of free radical oxidation and antioxidant protection in the mucous membrane of rat small and large intestines depending on the presence of nonalcoholic steatohepatitis. 30 mature outbred albino rats were involved into studies. The cumulative dose of doxorubicin was 15 mg/kg. In the mucous membrane of the small intestine of rats with nonalcoholic steatohepatitis, administration of doxorubicin resulted in less pronounced oxidative damage and 1.2-fold decrease in N-acetylneuraminic acid concentration compared to rats without nonalcoholic steatohepatitis. It has been proved that administration of doxorubicin led to the development of doxorubicin-induced oxidative stress in the intestinal mucosa of rats with more severe lesions of the small intestine, regardless of the presence of nonalcoholic steatohepatitis.