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Документ Influence of food additives complex on the morphology of villi of the rats’ duodenum mucosa(Полтавський державний медичний університет, 2022) Yeroshenko, G. A.; Grygorenko, A. S.; Shevchenko, K. V.; Lysachenko, O. D.; Riabushko, O. B.; Pyvovar, N. M.; Klepets, O. V.; Єрошенко, Галина Анатоліївна; Григоренко, Альона Сергіївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Рябушко, Олена Борисівна; Клепець, Олена Вікторівна; Пивовар, Ніна МихайлівнаThe study presents the findings of the study of the effect of food additives, namely, monosodium glutamate, sodium nitrite and Ponceau-4R on the morphological state of the components of the villi of the rats’ duodenal mucosa. The study was aimed at establishing the dynamics of changes in the metric parameters of the components of the villi of rats’ duodenal mucosa in normal conditions and under the action of the complex of food additives. It has been found that consumption of the complex of food additives leads to changes in the metric values of the height and width of the villi, which at the early stages of the experiment leads to a decrease in their mean values due to the immediate direct action on the mucous membrane with subsequent development of inflammatory reaction and edema, which will lead to an increase in metric values and a decrease in the number of epithelial cells of the villus. Adaptive mechanisms do not fully restore the values of the morphometric study, which is manifested by a decrease in the height of the villi by 20.25 % compared with the control group with an increase in the number of enterocytes with brush border and a decrease in the number of goblet cells by 44.41 %.Документ The impact of the complex food additives on the glandular apparatus of the rat’s duodenal mucosa(Полтавський державний медичний університет, 2021) Bilash, V. P.; Grygorenko, A. S.; Yeroshenko, G. А.; Shevchenko, K. V.; Lysachenko, O. D.; Zviaholska, I. M.; Tymoshenko, Yu. V.; Khilinska, T. V.; Білаш, Валентина Павлівна; Григоренко, Альона Сергіївна; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Лисаченко, Ольга Дмитрівна; Звягольська, Ірина Миколаївна; Тимошенко, Юлія Володимирівна; Хілінська, Тетяна ВолодимирівнаThe effect of a complex of food additives of monosodium glutamate, sodium nitrite and Ponceau 4R on the state of the crypt of the mucosa of the duodenum of rats in the early stages of the experiment leads to a decrease in mean morphometric values of crypt body components, which subsequently leads to disorders of microcirculation in blood vessels, the development of hypoxia and the occurrence of an inflammatory reaction. As a result, increasing dystrophic changes in the cells of the epithelium of the intestinal glands develop, which is manifested by a decrease in the average values of the quantitative indicator of the cellular composition of the epithelium of the crypts. Further, as a result of compensatory-restorative reactions, complete recovery does not occur, which is confirmed by a decrease in the mean values of the metric values of the crypt body with decreasing epithelial cell height, against a decrease in epithelial cell composition and local immunity during the experiment.