Кафедра пропедевтики внутрішньої медицини

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Anti-inflammatory activity of resveratrolin coronary heart disease
(Publishing Group "Vědecká perspektiva", 2023) Chekalina, N. I.; Чекаліна, Наталія Ігорівна
Treatment of Coronary Heart Disease (CHD) remains an open pressing issue of modern medicine. Worldwide, despite the numerous methods of correction of CHD that are being developed, there has been no improvement in the situation with morbidity and mortality. In developed countries, CHD remains in the first place in the structure of mortality from all causes. In Ukraine over the past decade, CHD accounted for 65-68% of all deaths in the structure of cardiovascular diseases (CVD). Among the able-bodied population in Ukraine, CHD leads to disability in 38.5%, and the average age of patients becomes younger.
Anti-inflammatory effects of resveratrol in stable coronary artery disease and concomitant autoimmune thyroiditis
(2016) Chekalina, N. I.; Чекалина, Наталья Игоревна; Чекаліна, Наталія Ігорівна
This study aims to examine the effect produced by resveratrol on markers of chronic systemic inflammation in patients with coronary artery disease (CAD) and concomitant autoimmune thyroiditis (Hashimoto's thyroiditis).The study enrolled 85 patients with coronary artery disease: stable exertional angina, class II, 30 of them were found out to have diagnosis of autoimmune thyroiditis (AIT) in its euthyroid state (experimental group), 55 patients made up the control group. In a month of CAD stabilization therapy (β-blockers, statins, aspirin), the levels of interleukin-1β (IL-1β), IL-10, tumor necrosis factor (TNF-α) and expression of mRNA inhibitor of kappa B gene (IkB) nuclear factor kB (NF-kB) transcription were measured in the blood of the patients. Then, the experimental group was additionally prescribed to take resveratrol in a dose of 100 mg per day. In 2 months since the beginning of the therapy including resveratrol the patients underwent re-examination. The patients with CAD and AIT comorbidity were found to have increased levels of IL-1β and TNF-α, moderate increase in IL-10. The findings obtained did not significantly differ from the data from those in the control group. Expression of mRNA IkB was identical in both groups. Under the influence of resveratrol in the patients of the experimental group the levels IL-1β and TNF-α were significantly decreased, the level of IL-10 was unchanged, and the expression of mRNA IkBα decreased (p <0,05). All these findings of the control group stayed unchanged. The results of the study demonstrate the anti-inflammatory properties of resveratrol in cases of CAD and concomitant AIT that are associated with reduced transcriptional activity of NF-kB; Целта на проучването е да се изследва ефекта на ресвератрол върху маркери на хронично системно възпаление при пациенти с исхемична болест на сърцето (CHD) във връзка с автоимунно тиреоидит (тиреоидит на Хашимото). В изследването са участвали 85 пациенти с исхемична болест на сърцето: ангина, стабилно напрежение, FC II, 30 от които имаше допълнителна диагностика на тиреоидит (проучвателна група) на Хашимото, тиреоиден опция, 55 пациенти, направени от групата сравнение. След един месец за стабилизиране CHD терапия (бета-блокери, статини, аспирин), при пациенти определяне нивата на интерлевкин-1β кръвта (IL-1β), IL-10, тумор некрозен фактор (TNF-α) и експресия на ген мРНК инхибитор капа В (IkB ) ядрен транскрипционен фактор kB (NF-kB). След това групата на проучване допълнително назначен ресвератрол в доза от 100 мг на ден и 2 месеца са повтори проучвания. ИБС пациенти в комбинация с повишени нива на AIT намерени IL-1β, TNF-α, IL-умерено повишаване на 10, данните не са значително различни от резултатите на контролната група. Експресията на мРНК IkB е идентичен и в двете групи. Под влиянието на ресвератрол при пациенти с нива на изследването IL-1β, TNF-α значително намалява нивото на IL-10 не се променя експресията на мРНК IkBα намалява (р <0,05), в сравнение, тези показатели не са се променили група. Тези резултати показват, противовъзпалителните свойства на ресвератрол в комбинация с CHD AIT, свързани с намалена транскрипционна активност на NF-кВ.
Application of the principles of socionics in the work of the curator of the academic group
(Полтавський державний медичний університет, 2023-10) Chekalina, N. I.; Чекаліна, Наталія Ігорівна
Relationships in an academic group are an essential component of the effectiveness of the educational process. Achieving psychological comfort and building friendly relations between students based on mutual respect and tolerance is also the responsibility of the academic group curator. One of the useful tools for implementing this task is socionics. The aim is to substantiate the feasibility of the practical application of socionics to create optimal relationships in the team and effective creative interaction in the educational process.
Bronchial obstruction as a factor of hemodynamic disturbances and electrical instability of the myocardium
(Полтавський державний медичний університет, 2023-03-23) Olatunji, Victor Oluwatimilehin; Чекаліна, Наталія Ігорівна; Боряк, Віктор Петрович; Chekalina, N. I.; Boriak, V. P.
Chronic obstructive pulmonary disease (COPD) is characterized by significant morbidity, which is contributed by risk factors of the modern environment, as well as high mortality due to respiratory failure and cardiovascular complications.
Changes in the indicators of stiffness and remodeling of magistral arteries in young patients at the early stage of essential hypertension under conditions of syntropy with obesity
(Aluna Publishing, 2024) Ivanytska, T. A.; Kazakov, Y. M.; Petrov, Y. Y.; Burmak, Y. H.; Ivanytskyi, I. V.; Chekalina, N. I.; Shut, S. V.; Іваницька, Тетяна Анатоліївна; Казаков, Юрій Михайлович; Петров, Євген Євгенович; Бурмак, Юрій Григорович; Іваницький, Ігор Валерійович; Чекаліна, Наталія Ігорівна; Шуть, Світлана Володимирівна
The study and analysis of indicators of remodeling and rigidity of magistral vessels in young essential hypertension patients with abdominal obesity and determination of the detected changes as a possible criterion for their remodeling.
Changes of endothelial function indices and pro-inflammatory cytokines level in comorbid course of essential hypertension
(NGO European Scientific Platform, 2022-08-05) Burmak, Y. H.; Petrov, Ye. Ye.; Ivanytska, T. A.; Іvanytskyi, І. V.; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Іваницька, Тетяна Анатоліївна; Іваницький, Ігор Валерійович
It should be noted that the peculiarity of internal pathology at present time is its comorbidity, besides essential hypertension (EH) sintropy worsens disease on the whole. Combination of EH with duodenal peptic ulcer (DPU) is frequent. It can complicate diagnostics, modify clinical symptoms and worsen treatment quality. The study aimed to identify the features of the changes of endothelial function parameters and pro-inflummatory cytokines level in patients with EH and comorbid DPU.
Changes of some immune and metabolic indices as burdening criterion of chronic systemic inflamation in the presence of the essential hypertension comorbidity
(2017) Burmak, Yu. G.; Kazakov, Yu. M.; Treumova, S. I.; Shilkina, L. N.; Petrov, Ye. Ye.; Kozlenko, T. V.; Бурмак, Юрій Григорович; Казаков, Юрій Михайлович; Треумова, Світлана Іванівна; Шилкіна, Людмила Миколаївна; Петров, Євген Євгенович; Козленко, Тетяна Вікторівна
The article highlights the cytokine profile features, severity of oxidative stress, changes of endothelium functions in patients with isolated course of essential hypertension and its combination with duodenal peptic ulcer. It describes evaluation of chronic systemic inflammation data: the level of serum cytokines (tumor necrosis factor -α, interleukins -1β, -6, -10), content of intermediate and end products of lipid peroxidation in blood (conjugated dienes, malondialdehyde), activity of antioxidant defense enzymes (superoxide dismutase, catalase), change of endothelium function (level of stable metabolites of nitrogen oxide in blood serum and severity of ristomycin-induced platelet aggregation). It was discovered that in the presence of tendency to increasing of interleukin-10 (р>0,05) , content of tumor necrosis factor -α, interleukins -1β and -6 in patients under condition of comorbidity significantly exceeded the reference data (р<0,001) and the data of patients with isolated course of essential hypertension. Thus was predetermined significant increase of ratio of pro-inflammatory cytokines to interleukin-10 that emphasized the presence of the highest pro-inflammatory activity of blood in patients with comorbid pathology. Later on in patients with comorbid pathology were identified the most significant manifestations of oxidative stress that was reflected in the highest level of conjugated dienes and malondialdehyde (р<0,001). It also turned out that the process of lipid peroxidation was proceeding under the condition of superoxide dismutase and catalase activity deficit that caused the greatest decrease of integrated indscator of the antioxidant capacity of the blood (р<0,001). It was discovered the negative relationship between high pro-inflammatory activity and low antioxidant ability of blood, reflecting the commonality of immune and metabolic processes in the mechanisms of the comorbid pathology development. This was also confirmed by the presence of inverse relationship between low total content of stable metabolites of nitrogen oxide in blood, as a reflection of the severity of endothelium dysfunction, and high pro-inflammatory blood activity (р<0,01) that also had a direct relationship with high ristomycin-induced platelet aggregation (р<0,01), as a high thrombogenic risk indicator in this category of persons. Therefore, identifying the relationship between indicators of chronic systemic inflammation in patients with essential hypertension in combination with duodenal peptic ulcer should be considered as a manifestation of a single mechanism of comorbid pathology formation, and most of their severity - as a burdening criterion of essential hypertension comorbidity.
Comparative analysis of assessment and self-assessment of media literacy of students of higher medical education at bachelor's and master's level
(Полтавський державний медичний університет, 2023) Ivanytska, T. A.; Petrov, Ye. Ye.; Kuzmenko, N. V.; Burmak, Yu. H.; Sakevych, V. D.; Іваницька, Тетяна Анатоліївна; Петров, Євген Євгенович; Кузьменко, Наталія Валентинівна; Бурмак, Юрій Григорович; Сакевич, Вікторія Дмитрівна
The article is devoted to the study of the level of media competence among students of higher medical education at the master's and bachelor's levels and a comparative analysis of the obtained results. The difference in the use of media literacy skills among the surveyed students was revealed. Part of the interviewees does not know how to check the source of information correctly, which causes the spread of unreliable information. The skill of correctly searching for medical data on the Internet and checking it is also insufficiently developed. Almost half of the respondents in both groups use the links offered by the search engine regardless of the source of information. A rather low number of medical education students use specialized medical databases. The majority of the students use information from textbooks to avoid mistakes. Some respondents believe that medical information cannot be unreliable. The vast majority of students, regardless of the educational level of higher education (bachelor's or master's), believe that they have mastered the basics of media literacy, although the skill of showing a critical attitude to information sources in the course of independent activities is not sufficiently developed. Therefore, there is a need to deepen media competences not only among students of higher medical education at the bachelor's level, but also at the master's level.
Comparative evaluation of the effectiveness of resveratrol and quercetin in patients with coronary heart disease according to daily Holter monitoring of electrocardiogram
(Видавнича група «Наукові перспективи», 2023) Chekalina, N. I.; Чекаліна, Наталія Ігорівна
The leading cause of death in the world remains Coronary Heart Disease (CHD), despite the many treatments being developed. Therefore, the search for new effective methods of treating CHD is extremely relevant. One of the pathogenetic mechanisms of atherosclerosis progression, which is the morphological basis of CHD, is chronic systemic inflammation. Anti-inflammatory activity at different levels of pro-inflammatory signaling has polyphenols of plant origin, which determined the direction of our scientific search.
COVID-19 в інтернатних установах системи соціального захисту населення: ефективні практики реагування
(Полтавський державний медичний університет, 2022-10-06) Соколенко, Лілія Олександрівна; Sokolenko, L. O.; Сакевич, Вікторія Дмитрівна; Козакевич, Олена Борисівна; Sakevych, V. D.; Kozakevych, E. B.
Нова коронавірусна інфекція, викликана вірусом SARS-CoV-2 (COVID-19), становить особливу загрозу для людей похилого та старечого віку. Однією з основних груп ризику є особи похилого віку, особи з інвалідністю, які проживають (перебувають) в інтернатних установах системи соціального захисту.
Daily monitoring of arterial pressure as a method of early diagnosis of arterial hypertension in young patients
(HSEE of Ukraine “Ukrainian Medical Stomatological Academy”, 2018) Ivanytska, T.; Burmak, Y.; Petrov, Ye.; Treumova, S.; Ivanytskyi, I.; Іваницька, Тетяна Анатоліївна; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Треумова, Світлана Іванівна; Іваницький, Ігор Валерійович
Thus, it can be concluded that daily monitoring of blood pressure is a highly sensitive method that allows diagnosing arterial hypertension in young patients in the early stages. It should be noted that the majority of patients with arterial hypertension had pathological daily profiles, which indicates an unfavorable prognosis and it needs for more careful management of such patients. It seems that we should change our traditional practice to diagnose and manage BP according to office measurements and more broadly use 24-h ABPM, particularly in young patients, to optimize BP control.
Differential diagnosis of soft tissue tumors
(Aluna Publishing, 2022) Kapustianskyi, Denys; Ivanytskyi, Ihor; Ivanytska, Tetiana; Zhamardiy, Valeriy; Donchenko, Viktoriia; Капустянський, Денис Васильович; Іваницький, Ігор Валерійович; Іваницька, Тетяна Анатоліївна; Жамардій, Валерій Олександрович; Донченко, Вікторія Іванівна
The aim of the study is to identify clinical signs of neurilemmoma of the upper limb, its main ultrasound and X-ray distinctions from other benign tumors of soft tissues. To make a preliminary diagnosis, it is advisable to use different methods of imaging, such as: ultrasound, MRI, radiography. Radiological diagnosis of soft tissue tumors should be based on the integrated use of radiological and ultrasound methods with mandatory consideration of clinical and anamnestic data such as patient age, topographic location of the tumor and its growth rate. Although ultrasound and MRI do not allow to completely differentiate the tumor, but they help to choose the right tactics of the patient. Treatment is to remove the tumor and includes cesium dissection and removal from the nerve bundle, using magnification.
Effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease
(Higher State Educational Establishment of Ukraine “Ukrainian Medical Stomatological Academy” — Poltava, Ukraine, 2017) Chekalina, N.; Shut`, S.; Trybrat, T.; Burmak, Yu.; Petrov, Ye.; Manusha, Y.; Kazakov, Yu.; Чекаліна, Наталія Ігорівна; Шуть, Світлана Володимирівна; Трибрат, Тетяна Анатоліївна; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Мануша, Юлія Іванівна; Казаков, Юрій Михайлович
The aim: The aim of our research was to study the effect of quercetin on parameters of central hemodynamics and myocardial ischemia in patients with stable coronary heart disease (CHD). Material and methods: The research involved 85 patients with CHD: stable angina pectoris, FC II, and 30 healthy individuals made up the control group. After 1.5 months of stabilizing therapy (β-blockers, statins, aspirin) patients with CHD were randomized into 2 groups — the research group (30 people) and the comparison group (55 people). Quercetin at a dose of 120 mg per os daily was added to standard treatment of the patients of the research group (with CHD), patients of the comparison group continued receiving the same treatment. The day before randomization and 2 months after prescribing differentiation therapy to the patients, echocardiography (echo) and 24 hour Holter ECG monitoring were made. Results: Clinical evaluation of echocardiography revealed that diastolic dysfunction of the left ventricle (LV) had been found in 100% of patients studied: in 97.6% — in the form of violation of relaxation (type I), in 2.4% of patients — in the form of pseudonormalization (type II). The 24 hour Holter ECG monitoring revealed episodes of myocardial ischemia (10.7+2.7 episodes a day), premature atrial contractions (PACs) and premature ventricular contractions (PVCs) in patients with stable CHD. After a two-month term of therapy in patients of both research and comparison groups left ventricular systolic function in terms of ejection fraction (EF) of LV significantly improved (by 4.5% and 3.2% respectively). LV diastolic function improved in both groups in terms of the ratio of the phases of the transmitral flow E/A, also IVRT significance decreased (p<0.05). DT value dropped significantly influenced by quercetin, in the comparison group it didn`t change. According to the 24 hour Holter ECG monitoring, the total time and number of episodes of ST segment depression decreased with dominative results in quercetin group. PVC number was significantly reduced only by influence of therapy with quercetin (р=0.0022). Conclusions: The data have shown cardioprotective properties of quercetin in conditions of CHD.
Estimation of systolic and diastolic function of the left ventricular myocardium among patients with chronic cor pulmonale of broncho-pulmonary genesis in combination with hypertensive disease
(2020) Treumova, S. I.; Petrov, Ye. Ye.; Burmak, Yu. G.; Треумова, Світлана Іванівна; Петров, Євген Євгенович; Бурмак, Юрій Григорович
Chronic obstructive lung disease is the main reason for the development of chronic cor pulmonale. Comorbidity of this disease with cardiovascular pathology is the most important, reflecting the unity of cardiorespiratory system, becoming a summary integral factor of a negative prognosis: chronic obstructive lung disease and cardiovascular diseases are considered as “criminal partners”. The aim of the study was to investigate the functional state of left ventricular myocardium in patients with chronic cor pulmonale of broncho-pulmonary genesis combined with hypertensive disease.
Evaluation and self-assessment of media literacy level of medical university students with an undergraduate degree and those who are high school graduates: there is still work to be done
(Полтавський державний медичний університет, 2022) Ivanytska, T. A.; Petrov, Ye. Ye.; Burmak, Yu. G.; Kuzmenko, N. V.; Sakevych, V. D.; Іваницька, Тетяна Анатоліївна; Петров, Євген Євгенович; Бурмак, Юрій Григорович; Кузьменко, Наталія Валентинівна; Сакевич, Вікторія Дмитрівна
The article highlights the main components of media competence. Special attention is paid to the level of media literacy of medical university students. The survey showed that there was no significant difference between the level of media literacy among undergraduate students and high school graduates. But there is a noticeable difference in the practical use of these soft skills, especially when using medical information. The majority of students of higher medical education believe they have media literacy skills and independently search for the necessary data on the Internet without noticing the source of information. Only 35% of respondents are interested in the author of the message or article. When preparing for classes, more than 75% of students use textbooks. Among high school graduates, only 20% use specialized medical databases, in the group with undergraduate degree, this share is below 10%. Almost 40% of high school graduates do not check the reliability of the source of medical information. To improve the skills of medical university students for selective perception of information, teachers of clinical disciplines should pay more attention to the development of critical thinking skills and data analysis of the professional information.
Evaluation of indicators of endothelial dysfunction and intracardiac hemodynamics of the left ventricle in patients with chronic pulmonary heart bronchopulmonary genesis of comorbidity with essential arterial hypertension
(Wydawnictwo Aluna, 2019) Treumova, S. I.; Redchyts, I. V.; Trybrat, T. A.; Shut, S. V.; Honcharova, O. O.; Boriak, V. P.; Треумова, Світлана Іванівна; Трибрат, Тетяна Анатоліївна; Шуть, Світлана Володимирівна; Гончарова, Олена Олегівна; Боряк, Віктор Петрович; Редчиць, Іван Васильович
Chronic obstructive pulmonary disease (COPD) is the main cause of progression chronic pulmonary heart (CPH), it is a serious worldwide problem. The combination of COPD with essential arterial hypertension (EAH) ranges from 4 to 27.7% with increasing age.
Features of cytokine profile and endothelial function in comorbid course of essential hypertension
(2018) Burmak, Yu. G.; Petrov, Ye. Ye.; Treumova, S. I.; Ivanitskaya, T. A.; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Треумова, Світлана Іванівна; Іваницька, Тетяна Анатоліївна
Appearance of the new terminology such as “endothelial dysfunction” and “chronic systemic inflammation” has designated a new round in the study of essential hypertension (EH), namely – to defining the role of the immune inflammatory mechanisms in the development and progression of vascular pathology [1, 6, 8]. It should be noted that the peculiarity of internal pathology at present time is its comorbidity [2, 9, 10], besides EH comorbidity worsens disease on the whole [3, 4]. Combination of EH with duodenal peptic ulcer (DPU) is frequent. It can complicate diagnostics, modify clinical symptoms and worsen treatment quality [7]. The foregoing formed basis of this study. The study aimed to identify the features of the changes of the cytokine profile and endothelial function in patients with EH and comorbid DPU.
Gender and age aspects in the pathogenesis of bone mineral density disorders
(Aluna Publishing, 2023-09) Chekalina, N. I.; Plaksa, V. M.; Kazakov, Yu. M.; Tribrat, T. A.; Shut, S. V.; Petrov, Ye. Ye.; Ivanytskay, T. A.; Чекаліна, Наталія Ігорівна; Плакса, Вікторія Михайлівна; Казаков, Юрій Михайлович; Трибрат, Тетяна Анатоліївна; Шуть, Світлана Володимирівна; Петров, Євген Євгенович; Іваницька, Тетяна Анатоліївна
Osteoporosis is a systemic progressive disease of the musculoskeletal system, caused by the loss of bone mass with the disrupted microarchitectonics of bone tissue, which leads to an increase in bone fragility and the risk of fractures. This disease is observed in all age groups, regardless of gender and race, but the highest prevalence is observed in Caucasians (white race), postmenopausal women, and the elderly. With an aging population and a decrease in life expectancy, osteoporosis is increasingly becoming a global epidemic
Hypomagnesemiaas a predictor of early remodeling of blood vessels in young men with essential hypertension
(Yerevan State Medical University #2 Koryun St., Yerevan. 0025, Armenia, 2020-04) Ivanitskaya, T. A.; Burmak, Yu. G.; Ivanitskiy, I. V.; Petrov, Ye. Ye.; Kazakov, Yu. M.; Shut, S. V.; Іваницька, Тетяна Анатоліївна; Бурмак, Юрій Григорович; Іваницький, Ігор Олексійович; Петров, Євген Євгенович; Казаков, Юрій Михайлович; Шуть, Світлана Володимирівна
The article highlights the features of changes in the level of magnesium in the serum, the elasticity of the vascular wall and shows their relationship in young men with essential hypertension and abdominal obesity. The indices of magnesemia, the markers of the arterial wall elasticity (the augmentation index, the arterial stiffness index and the pulse wave velocity), and the thickness of the perivascular adipose tissue (extra-media of car otid arteries) were evaluated. Clinical manifestations of magnesium deficiency were identified in more than half of the cases and the risk of its development was found in a third of patients with essential hypertension and obesity, it correlated with the results of laboratory studies of serum magnesium levels. Besides, the severity of hypomagnesemia was inversely proportional to the blood pressure (r=-0.58, p=0,022).Evaluation of vascular wall stiffness markers in patients with essential hypertension and obesity showed their significant increase not only in comparison with the similar indicators of practically healthy individuals but also with the parameters of patients with essential hypertension without obesity. The correlation analysis revealed that the magnesium level in the serum of such patients had a strong negative relationship with both the augmentation index (r =-0.68, p =0.023) and the arterial stiffness index (r=-0.55, p=0,042).The extra media index in patients with essential hypertension and obesity was twice as high as one in practically healthy individuals. It was also revealed that the extra-media indicator in these patients was positively related to the level of blood pressure (r=+0.68, p=0.033), the augmentation index (r =+0.48, p=0.018), and negatively related to magnesium content in serum (r= +0.61, p=0.023). It was concluded that young men with essential hypertension and abdominal obesity have clinical signs of hypomagnesemia. The identified correlations between the serum magnesium content, the increase in arterial wall stiffness and the level of the blood pressure in such patients make it possible to consider hypomagnesemia as a predictor of early vascular remodeling.
Influence of betargin and quercetin on indicators of chronic systemic inflammation in patients with coronary heart disease concurrent with non-alcoholic fatty liver disease
(2019) Kazakov, Yu.; Manucha, Yu.; Hliebov, V.; Boriak, V.; Sakevych, V.; Казаков, Юрій Михайлович; Мануша, Юлія Іванівна; Сакевич, Вікторія Дмитрівна; Боряк, Віктор Петрович
Introduction. Comorbidity is one of the major issues of modern medicine, characterized by masking of pathological conditions, aggravated course and unfavorable prognosis

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