Кафедра нервових хвороб

Постійне посилання на фонд

https://repository.pdmu.edu.ua/handle/123456789/30

Переглянути

Зараз показуємо 1 - 20 з 451

A clinical case of adult diagnosis of microduplication syndrome of chromosome 15 at site 15q11.2
(2024) Delva, M. Yu.; Hryn, K. V.; Delva, I. I.; Pinchuk, V. A.; Kryvchun, A. M.; Sylenko, G. Ya.; Purdenko, T. I.; Дельва, Михайло Юрійович; Гринь, Катерина Вікторівна; Дельва, Ірина Іванівна; Пінчук, Вікторія Анатоліївна; Кривчун, Анжеліна Михайлівна; Силенко, Галина Ярославівна; Пурденко, Тетяна Йосипівна
The 15q11.2 microduplication syndrome is a rare genetic disease caused by the duplication of a small segment of the genetic material of the chromosome 15, to date it remains unknown to the physicians. The aim of the study was to compile an algorithm for diagnosing 15q11.2 microduplication syndrome in adults and differentiating it from a phenotypically similar genetically determined condition (Prader-Willi syndrome). Materials and methods – a clinical case of 15q11.2 microduplication syndrome with mild clinical course was described; neurological, clinical and psychopathological examination was performed, functional diagnostic methods were used. The described clinical case of a relatively mild clinical course of the 15q11.2 microduplication syndrome and its diagnosis in adulthood indicates a significant phenotypic variability of this phenomenon. This study demonstrates the coincidence of clinical manifestations present in the patient with the currently described symptoms of microduplication of a fragment of the fifteenth chromosome 15q11.2. The results of molecular genetic study with the detection of duplication at the 15q11.2 locus (by STR marker D15S817) are unquestionable confirmations of this syndrome.
A study of the time-based characteristics of phenomenology of post-stroke fatigue over the first year after stroke occurrence
(Українська медична стоматологічна академія, 2018) Delva, I. I.; Дельва, Ірина Іванівна; Дельва, Ирина Ивановна
Post-stroke fatigue (PSF) is a common medical and social problem. Aim: to analyze time-based characteristics of PSF over the first year after stroke event. Material and methods. Patients were examined through definite time slots: during hospital staying (234 cases), in 1 month (203), in 3 months (176), in 6 months (156), in 9 months (139) and in 12 months (128 cases) after stroke. PSF was measured by fatigue assessment scale (FAS) and multidimensional fatigue inventory-20. (MIF-20) We conditionally divided all PSF cases into early PSF group (presented only within the 1st month after stroke), persistent PSF (presented within the 1st post-stroke month and later) and late PSF (appeared only in 3rd month observation or later). Results. Having analyzed all PSF cases according to FAS, we found out 15 PSF cases (16,0%) were assessed as early PSF, 51 (54,2%) assessed as persistent PSF and 28 (29,8%)– as late PSF. For all timebased types of PSF domains, according to MIF-20, the similar pattern of distribution was observed: early PSF domains – from 16,3% to 20,3%, persistent PSF domains – from 54,15 to 59,8%, late PSF domains – from 23,9% to 26,0%. All domains of early PSF, according to MIF-20, were statistically more intensive than all corresponding domains of persistent PSF and late PSF, whereas intensities of all persistent PSF domains and all late PSF domains were much or less similar. Conclusions. 1. About 20% of all PSF cases are early PSF, 25% are late PSF and slightly more than half of all cases is persistent PSF. 2. Proportions of all domains of early PSF, late PSF and persistent PSF are practically similar. 3. Significant differences between severities of early PSF and persistent PSF as well as late PSF can be as indirect evidences that all timebased PSF types are quite distinctive entities.
Adaptation of polymerase chain reaction-restriction fragment length polymorphism method for polymorphism (rs2583988) analysis in alpha-synuclein gene
(Українська медична стоматологічна академія, 2020) Tarianyk, K. A.; Lytvynenko, N. V.; Oliinychenko, V. K.; Byslik, T. V.; Pochernyaev, K. F.; Таряник, Катерина Анатоліївна; Литвиненко, Наталія Володимирівна; Олійниченко, Є. К.; Буслик, Т. В.; Почерняєв, К. Ф.
The article suggests the polymerase chain reaction-restriction fragment length polymorphism method for a single nucleotide polymorphism (rs2583988) detection for further prediction of Parkinson’s disease risks. Based on the meta-analysis results for the single nucleotide polymorphism rs2583988 (C>T) in αlpha-synuclein gene; current polymorphic variant was chosen by analyzing bioinformatical and genetic studies. We have designed a pair of primers and conditions for restriction analysis to detect different alleles in rs2583988. As a result, there was developed a simple and affordable method for detecting single nucleotide polymorphism rs2583988 alleles. The method is expected to be suitable for clinic laboratories, due to affordable cost and equipment, and to be used in further association studies.
Advantages and Challenges of Global Mobility
(2021-02-12) Lysanets, Yu. V.; Morokhovets, H. Yu.; Purdenko, T. Y.; Ostrovska, L. Y.; Мороховец, Галина Юрьевна; Лисанец, Юлия Валериевна; Пурденко, Татьяна Иосифовна; Островская, Людмила Иосифовна; Мороховець, Галина Юріївна; Лисанець, Юлія Валеріївна; Пурденко, Тетяна Йосипівна; Островська, Людмила Йосипівна
Analysis of primary headaches management in Poltava regions
(Aluna Publishing, 2021) Delva, M. Yu.; Delva, I. I.; Дельва, Михайло Юрійович; Дельва, Ірина Іванівна
The aim: Assess quality of diagnosis and treatment of primary headaches (PH) in Poltava region. Materials and methods: There were examined 195 patients with PH who were previously consulted by different specialists due to headaches. We analyzed previously established diagnoses, previous consultations and prescribed investigations due to headache, drugs that were prescribed for headache treatment. Results: The misdiagnoses of PH were made due to considering the headache as secondary (as sign of dyscirculatory encephalopathy, arterial hypertension, autonomic dysfunction, cervical ostheochondrosis). Patients older 40 years were misdiagnosed more often with dyscirculatory encephalopathy, while patients under 40 years were more frequently misdiagnosed with autonomic dysfunctions. Patients sought medical help for headache problem and were repeatedly examined by different specialists (general practitioner, neurologist, cardiologist, ophthalmologist, oyorhinolaryngologist, neurosurgeon). Doctors prescribed a large number of identical uninformative neuroimaging and neurofunctional methods regardless of PH nosologies. Also it had been often prescribed therapy with the use of vascular, metabolic, nootropic drugs without specific pathogenetic effects for PH. Conclusions: It is necessary to improve the diagnosis and treatment of PH according to international standards by raising awareness among general practitioners, neurologists and other specialists about the basics of PH diagnosis and treatment.
Association between emotional-volitional dysfunction and features of aggression or hostility in mens with different forms of substance addictions: a cross-sectional study
(Aluna Publishing, 2020) Zhyvotovska, L. V.; Boiko, D. I.; Kadzhaia, N. V.; Shkodina, A. D.; Demianenko, I. V.; Borysenko, V. V.; Животовська, Лілія Валентинівна; Бойко, Дмитро Іванович; Шкодіна, Анастасія Дмитрівна; Борисенко, Володимир Васильович
The aim: The research aim was to study features of emotional-volitional sphere and its association in mens with different forms of Substance Addictions. Materials and methods: We examined 146 patients with alcohol and drug addictions using Toronto Alexithymia Scale, Zverkov-Eidmann`s questionnaire and Buss-Durkee questionnaire. Results: The study showed an increase in the overall level of alexithymia, a moderate level of aggressiveness and a sufficient level of volitional self-regulation without a significant difference between the groups. The indirect correlation of “persistence” with the “general level of alexithymia”, “difficulty identifying feelings” and “physical aggression” in group 1 and at the same time the indirect correlation between “self-control” and “verbal aggression” and “volitional self-regulation” with “difficulty describing feelings” can be explained by the opposite meaning of these concepts and phenomena themselves.However, it is interesting that the indicators “physical aggression” and “difficulty describing feelings” in group 2 were significantly lower, but at the same time correlated with “general level of alexithymia” and “irritability”, respectively. On other hand in group 1 the indicator “suspiciousness” is directly related to the “general level of alexithymia”, but its level is significantly lower in comparison with group 2. Conclusions: The phenomenon of alexithymia is not only recorded in the clinical picture of patients with various forms of addiction, but can also induce the development of manifestations of aggressiveness and hostility in them. Correction of alexithymia is necessary to understand the emotional state of these patients and choose the right approach to their treatment and rehabilitation.
Changes of structural organization of human olfactory bulbs under conditions of severe forms of pneumonia and cerebrovascular pathology
(Дніпропетровський державний медичний університет, 2021) Shkodina, A. D.; Grinko, R. M.; Starchenko, I. I.; Vynnyk, N. I.; Sovhyria, S. M.; Kyslyi, V. F.; Шкодіна, Анастасія Дмитрівна; Грінько, Руслана Миколаївна; Старченко, Іван Іванович; Винник, Наталія Іванівна; Совгиря, Світлана Миколаївна; Кислий, Владислав Федорович
The role of human olfactory bulbs remains one of the most interesting questions concerning work of the brain, because this organ is one in which neurogenesis is continuously generated in post-natal and adult periods. Impaired sense of smell is not a pathology that threatens human life, therefore, often remains unnoticed. However, it can directly affect the quality of life, as it leads to malnutrition and certain problems in interpersonal relationships. The study of the functional structure of the olfactory analyzer plays an important role both in clinical and experimental studies, but the question of its features in humans needs detailed research. The material of the research was 18 pairs of the olfactory bulbs of males and females aged from 30 to 90 years that were received at the Poltava Regional Department of Pathology. In order to objectify the data obtained on micropreparations, the following morphometric indices were determined: the specific gravity of the location of cellular elements; the proportion of mitral neurocytes in the entire cell population; percentage ratio of relative quantity between cellular elements, blood microvessels, fibrillar component and homogeneous eosinophilic structures. Correlation analysis of morphometric indices in the general sample revealed the existence of an inverse communication of average strength between the relative number of homogeneous eosinophilic cells and the relative number of cellular elements and blood microvessels, which in turn indicates the etiopathogenetic mechanisms of the formation of these structures. The conducted research makes it possible to conclude that mitral cells as one of the most differentiated in olfactory bulbs are sensitive to the development of hypoxic states; under the conditions of cerebrovascular pathology, the relative amount of the blood vessels of the microvessels decreases, which leads to the disorder of the trophy of the nervous tissue and as a result can lead to neurocytolysis of mitral cells. Changes in the vascular and cellular component indicate a different pathogenesis of changes in human olfactory bulbs in these pathologies and suggest that eosinophilic homogeneous cells are the result of apoptotic neurocytolysis against the background of development of hypoxic states.
Chronotype and daily functioning of patients with different motor subtypes of parkinson disease
(Полтавський державний медичний університет, 2024) Shkodina, A. D.; Bardhan, M.; Tarianyk, K. A.; Delva, M. Yu.; Шкодіна, Анастасія Дмитрівна; Бардхан, Майняк; Таряник, Катерина Анатоліївна; Дельва, Михайло Юрійович
Introduction. Sleep and circadian rhythm disturbances can occur at any stage of Parkinson disease (PD) and significantly affect quality of life. Chronotypes of patients with PD are associated with different phenotypes, in particular with the motor subtype. Thus, we hypothesized that patients with different motor subtypes of PD may have differences in the distribution of chronotypes and patterns of daily activity. Methods and materials. We conducted clinical research on the basis of the Centre for Parkinson Disease and Neurodegenerative Diseases of the Department of Neurological Diseases of Poltava State Medical University. PD was verified according to the recommendations of the International Movement Disorders and Parkinson's Disease Society. The motor subtype of PD was determined by the Stebbin method, which is based on the calculation of the Stebbins coefficient by the sum of the Unified PD Rating Scale scores. The examined patients were divided into 3 groups according to the motor subtype of PD: group 1 (n = 38) - patients with PD subtype with the predominance of postural instability and gait disorders (PIGD); group 2 (n = 26) - patients with PD subtype with the predominance of tremor and mixed subtype; control group (n = 30) - conditionally healthy individuals without CNS lesions. Circadian patterns were analyzed using the Munich Chronotype Questionnaire (MCTQ). Results. It was found that in PD patients sleep onset and time of getting out of bed was later (p<0.001 and p=0.042, respectively), sleep latency was longer (p<0.001), sleep duration was shorter (p=0.001), the mid-sleep corresponded to a later time (p<0.001). Patients with the PIGD subtype had a later time of getting out of bed (p=0.038), longer sleep inertia (p<0.001), shorter sleep duration (p<0.001), and later mid-sleep time (p=0.028). We have shown the tendency of patients with PD, mostly in the PIGD subtype, to later chronotypes (p<0.001). Light exposure indirectly moderately correlated with mid-sleep in all study groups. It was found that both the motor subtype (p<0.001) and the level of light exposure during the day (p<0.001) statistically significantly affect the mid-sleep. Conclusion. Thus, we have found that patients with PD differ from age-matched controls without neurodegenerative diseases by chronotype and circadian pattern of functioning. The motor subtype of the disease is associated with circadian differences, namely, the PIGD subtype is associated with shorter sleep duration, a predisposition to a later chronotype, and longer sleep inertia.
Circadian rhythm disorder and anxiety as mental health complications in post‑COVID‑19
(Springer, 2022) Boiko, D. I.; Skrypnikov, A. M.; Shkodina, A. D.; Hasan, M. M.; Ashraf, G. M.; Rahman, M. H.; Бойко, Дмитро Іванович; Скрипніков, Андрій Миколайович; Шкодіна, Анастасія Дмитрівна
In 2020, the world gained dramatic experience of the development of the 2019 coronavirus disease pandemic (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Recent researches notice an increasing prevalence of anxiety and circadian rhythm disorders during COVID-19 pandemic. The aim of the study was describing clinical features of circadian rhythm disorders and the level of anxiety in persons who have had COVID-19. We have conducted a cohort retrospective study that included 278 patients who were divided into 2 study groups according to medical history: group 1 includes patients with a history of COVID-19; group 2 consists of patients who did not have clinically confrmed COVID-19 and are therefore considered not to have had this disease. To objectify circadian rhythm disorders, they were verifed in accordance with the criteria of the International Classifcation of Sleep Disorders-3. The level of anxiety was assessed by the State-Trait Anxiety Inventory. The most common circadian rhythm disorders were sleep phase shifts. We found that COVID-19 in the anamnesis caused a greater predisposition of patients to the development of circadian rhythm disorders, in particular delayed sleep phase disorder. In addition, it was found that after COVID-19 patients have increased levels of both trait and state anxiety. In our study, it was the frst time that relationships between post-COVID-19 anxiety and circadian rhythm disorders had been indicated. Circadian rhythm disorders are associated with increased trait and state anxiety, which may indicate additional ways to correct post-COVID mental disorders and their comorbidity with sleep disorders.
Circadian rhythm disorders and non-motor symptoms in different motor subtypes of Parkinson's disease
(Georgian Association of Business Press, 2021) Tarianyk, Kateryna A.; Shkodina, Anastasiia D.; Lytvynenko, Nataliya V.; Таряник, Катерина Анатоліївна; Шкодіна, Анастасія Дмитрівна; Литвиненко, Наталія Володимирівна
The phenotype of the disease depends not only on the prevalence of certain motor signs, but also on non-motor symptoms. Determination of different profiles of Parkinson's disease improves disease prognosis and management. A clinical study was conducted in patients with Parkinson's disease. For this purpose, 64 patients with various motor subtypes of the disease were examined. Diagnosis was made according to the UK Brain Bank Criteria. The patients were divided into groups according to the motor subtype verified by the results of interference electroneuromyography. In each group, demographic data were collected, staging according to the Hoehn-Yahr scale and the overall score of the unified UPDRS scale were studied. The study of gait was evaluated using the Nonmotor Symptom Rating Scale for Parkinson's Disease (NMSS). The Munich Chronotype Questionnaire (MCTQ) was used to determine sleep onset, wake-up time, sleep duration, mid-sleep, average sleep duration, average weekly light exposure, chronotype, and for working patients, relative jet lag and average weekly sleep deficit. Circadian rhythm disorders were diagnosed according to the international classification of sleep disorders-3. Patients with Parkinson's disease have a more characteristic evening chronotype and a shorter sleep duration due to late sleep onset. On the other hand, the tendency towards the morning or evening chronotype is not associated with the severity of the disease or the level of daytime sleepiness. It was found that PD patients are characterized by more pronounced disorders of the gastrointestinal, genitourinary systems, sleep and cognitive-affective disorders, and others. In patients with a mixed motor subtype, mood and cognitive impairments are more pronounced, and gait disorders are more pronounced in patients with a mixed motor subtype. Thus, different motor subtypes of Parkinson's disease have differences in the severity of motor manifestations and features of the circadian rhythm. Circadian dysregulation is associated with features of daily functioning and disorders of the motor sphere.
Clinical and psychopathological features of internally displaced women with adjustment disorders
(Українська медична стоматологічна академія, 2021) Isakov, R. I.; Skrypnikov, A. M.; Herasymenko, L. O.; Hryn, K. V.; Kydon, P. V.; Vdovina, O. O.; Ісаков, Рустам Ісроїлович; Исаков, Рустам Исроилович; Скрипніков, Андрій Миколайович; Скрипников, Андрей Николаевич; Герасименко, Лариса Олександрівна; Герасименко, Лариса Александровна; Гринь, Катерина Вікторівна; Гринь, Екатерина Викторовна; Кидонь, Павло Володимирович; Кидонь, Павел Владимирович; Вдовіна, Олена Олександрівна; Вдовина, Елена Александровна
Vast numbers of internally displaced persons and the threatening growth rate of emigration create the need to pay increased attention to various aspects of psychopathological conditions that arise in response to changes in habitual living conditions. In addition to clinical consequences, the prevalence is accompanied by significant negative social and economic consequences both for society as a whole and for the patient himself, significantly deteriorating his quality of life and level of social functioning. There are significant gender differences in crisis response, in particular, women are the most vulnerable in the vast majority of stressful situations. We carried out a comprehensive clinical, psychopathological and psychodiagnostics examination of 48 internally displaced persons with the established adjustment disorder (F43.2) with studying and careful analysis of anamnestic data using a special questionnaire. The study found that the leading clinical manifestations of internally displaced women are the presence of anxiety and depression in the structure of adjustment disorders, social disintegration and the presence of psychosocial maladjustment. Clinical differences of internally displaced women with adjustment disorders affect the quality of life, change the system of social support and values, contribute to the reduction of productive activities in everyday life.
Clinical, pharmacotherapeutic and biorhythmological peculiarities of depressive disorders, comorbid with cardiovascular pathology
(м. Тбілісі, 2021) Hryn, K.; Sydorenko, A.; Vlasova, O.; Kolot, E.; Martynenko, Y.; Гринь, Катерина Вікторівна; Сидоренко, Антоніна Григорівна; Власова, Олена Вікторівна; Колот, Еліна Георгіївна; Мартиненко, Яніна Павлівна
The spread of depressive disorders is extra high nowadays. Depressive disorders are widespread mental disorders in the structure of mental pathology, both causes of psychiatrists’ visit, and causes of medical aid. The presence of depressive syndrome in patients with cardiovascular system leads to deterioration patient’s condition and adaptive abilities and aggravates somatic abnormality. Adequate therapy causes their reduction, prevention of recurrence and decompansation of comorbid somatic pathology, and eliminates severe medical and prevents social consequences. The study of clinical aspects of depressive conditions which are accompanied with pathology is one of the direction not only psychiatric, but also common pharmacotherapeutic investigations. The aim of the investigation was to determine clinical, pharmacotherapeutic and biorhythmic peculiarities of depressive disorders in patients with comorbid cardiac pathology. And also assessment of efficacy of complex therapy based on chronotherapy principle was used. 50 patients (female patients) with depressive disorders were involved in this investigation. This was performed based on “Depressive disorders of organic genesis, characterized by somatic pathology” (F 06.35), “Somatoform disorder” of heart and cardiovascular system (F 45.30), “Mild depressive episode” (F 32.00), and also comorbid arterial hypertension confirmed by physician. Clinical, laboratory, clinical and psychopathological investigations using psychodiagnostic scales (scale HAMD-21, CGI-S, CGI-І) were used. Individual biorhythmic status was established and it requires medicamentous therapy. Comparing patients of both groups, it has been detected a group of patients in whom principles of chronotherapy, especially antihypertensive and antidepressive therapy were prescribed, dynamics of patient’s improvement was better than in the investigated group where the principle of chronotherapy was observed.
Cognitive and affective disturbances in patients with Parkinson's disease: Perspectives for classifying of motor/neuropsychiatric subtypes
(Elsevier, 2022-06) Shkodina, Anastasiia D.; Tarianyk, Kateryna A.; Boiko, Dmytro I.; Zehravi, Mehrukh; Akter, Shamima; Ashraf, Ghulam Md.; Rahman, Md. Habibur; Шкодіна, Анастасія Дмитрівна; Таряник, Катерина Анатоліївна; Бойко, Дмитро Іванович
Parkinson’s disease (PD) is a neurological disorder, related to rigidity, bradykinesia, and resting tremors, among other motor symptoms. It is noticed in the increasing frequency of neuropsychiatric disorders, which may be also caused by non-motor symptoms of PD. Treatment of PD is usually based on the classification of motor subtypes; however, it remains unclear whether motor subtypes have differences in the severity of psychiatric symptoms. It determines the importance of discovering possible neuropsychiatric subtypes of PD. We conducted a clinical study, which included group 1 - patients with postural instability and gait disorders dominant (PIGD) subtype, group 2 - patients with tremor dominant (TD) and indeterminate subtypes (non-PIGD), and group 3 - people who did not have CNS damage. We used the Montreal Cognitive Assessment, Russified 20-point version of the Toronto Alexithymia Scale, State-Trait Anxiety Inventory, and Beck Depression Inventory for assessment of the mental status. It was the first time that neuropsychiatric subtypes of PD had been investigated based on the condition of cognition and mood. Cluster analysis gave us the possibility to classify our patients by the following subtype: affective-cognitive PIGD, anxious PIGD, affective-cognitive non-PIGD, and non-PIGD without psychiatric symptoms. This indicates a closed link between psychiatric and motor symptoms, which can be used for the improved treatment of PD.
Cognitive and motor impairments in different motor subtypes of parkinson disease and patients’ quality of life
(Полтавський державний медичний університет, 2024) Shkodina, A. D.; Шкодіна, Анастасія Дмитрівна
Numerous motor and non-motor symptoms characterize Parkinson's disease. Modern research increasingly focuses on their relationship and role in patients' quality of life. Our study aimed to evaluate cognitive and motor impairment in different motor subtypes of PD and analyze their relationship with quality of life. The study included 64 patients with Parkinson's disease, divided according to motor subtype: group 1 - patients with PD subtype with a predominance of postural instability and gait disorders; group 2 - patients with PD subtype with a predominance of tremor or intermediate subtype. The patients were examined using the Unified Parkinson's Disease Rating Scale, the Hoehn and Yahr scale, the Montreal Cognitive Assessment Scale, and the Parkinson's Disease Quality of Life Scale. It was found that group 1 had a statistically significant higher score on the "mobility" (p=0.004) and "emotional well-being" (p=0.013) scales, indicating a greater severity of motor function impairment and psychoemotional disorders in these patients. At the same time, the score on the "stigmatization" scale was found to be higher in group 2 (p=0.049). There were no differences in the scales of "daily activity", "social support", "cognition", "communication" and "body discomfort". The total score on the PDQ-39 scale was higher in group 1 compared to group 2 (p=0.042), indicating a worse quality of life. We found a worse quality of life in patients with PIGD subtype of PD, in particular in the domains of mobility and "emotional well-being", while patients with non-PIGD subtype were characterized by a more acute perception of disease stigma, in the absence of differences in the severity of clinical symptoms and cognitive impairment.
Contemporary theories of globalization and their relevance to higher education
(Полтавський державний медичний університет, 2022-11-25) Morokhovets, H.; Lysanets, Yu.; Ostrovska, L.; Purdenko, T.; Мороховець, Галина Юріївна; Лисанець, Юлія Валеріївна; Островська, Людмила Йосипівна; Пурденко, Тетяна Йосипівна
У рамках сучасної соціологічної теорії ідеї глобалізації відіграють центральну й вирішальну роль. Серед найбільш суперечливих сучасних концепцій у статті виокремлено та проаналізовано студії прибічників теорій гіперглобалізму та їхніх опонентів – “скептиків”. Обидві концепції прогнозують досить різні результати щодо наслідків процесу глобалізації. Відповідні висновки мають першочергове значення для розуміння тенденцій розвитку світу загалом і вищої освіти зокрема.
Correction of non-motor vegetative fluctuations with Parkinson`s disease based on levodopa treatment
(2014) Tarianyk, K. A.; Таряник, Катерина Анатоліївна
The influence of dopamin receptors agonists in the transdermal and oral forms of drugs and amantadine for non-motor autonomic fluctuations of ptients with different duration of the disease during the treatment of Parkinson`s in a stable dose of levodopa were established. It was analysed, that the dopamin receptors agonists in the transdermal and oral forms of drugs reduce the frequency of duration of vegetative non-motor fluctuations in patients with Parkinson`s disease. The use of amantadine sulfate has little effect in a decrease non-motor autonomic fluctuations.
Devic’s opticomyelitis: a case report from the authors’ clinical practice
(Журнал Польської медичної асоціації, Видавництво ALUNA, Польща, 2021) Purdenko, T. Y.; Lytvynenko, N. V.; Pushko, O. O.; Ostrovska, L. Y.; Hladka, V. M.; Tarianyk, K. A.; Sylenko, H. Ya.; Kolliakova, Y. A.; Пурденко, Тетяна Йосипівна; Литвиненко, Наталія Володимирівна; Пушко, Олександр Олександрович; Островська, Людмила Йосипівна; Гладка, Вікторія Михайлівна; Таряник, Катерина Анатоліївна; Силенко, Галина Ярославівна; Коллякова, Євгенія А.
The aim was to analyze the contemporary scientific literature on Devic’s opticomyelitis and to present a case report from our clinical practice. Based on the patient’s complaints, case history and features of clinical course, objective neurological status, clinical laboratory and additional examination methods, characteristic MR-patterns, consultations of related specialists and differential diagnostics, we made the clinical diagnosis according to ICD-10: G36.0 Devic’s opticomyelitis, exacerbation, with a sustained bilateral lesion of the optic nerves in the form of retrobulbar neuritis with the development of partial atrophy of the optic nerves in both eyes, spinal cord lesions with common cystic, cicatrical and atrophic alterations at C1-Th8 level with moderate lower paraparesis, expressed by sensory ataxia, sensory disturbances by the descending conductive type from Th10, mpaired function of pelvic organs by the type of acute urinary retention, asthenic and neurotic syndrome. Widespread cases of demyelinating pathology in medical practice and complexity of differential diagnostics determine the need for a specific diagnostic algorithm. This algorithm should consider anamnestic data along with the course of the disease, clinical, laboratory and instrumental examination, including neuroimaging, analysis of CSF for oligoclonal bands, analysis for IgG antibodies to AQP4, which will allow to carry out diagnostics and to decide on tactics for further management of patients of this cohort. Further research is needed to conduct additional studies for optimization of tactics for dynamics monitoring and improvement of diagnostic, treatment and rehabilitation measures in patients with Devic’s opticomyelitis, including appropriate immunological control, given the complexity of differential diagnostics and the affinity of this pathology to multiple sclerosis.
Diagnostic errors during intramedullar processes
(Aluna Publishing, 2019) Tarianyk, K. A.; Lytvynenko, N. V.; Purdenko, T. Y.; Hladka, V. M.; Таряник, Катерина Анатоліївна; Литвиненко, Наталія Володимирівна; Пурденко, Тетяна Йосипівна; Гладка, Вікторія Михайлівна
Introduction: The article describes a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which remained undetected for many years and was treated as syringomyelia. Long-term exhausting examinations of the brain and spinal cord, dynamic follow-up of medical specialists, and repeated surgical interventions on the spine helped to differentiate this process and make the correct diagnosis. The aim: The objectives of the present paper are to analyze the existing classifications of syringomyelia; to examine its etiology, pathogenesis, diagnostic approaches and treatment tactics; to present a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which was misdiagnosed as syringomyelia. Materials and methods: The authors analyzed the existing classifications of syringomyelia and studied its etiology, pathogenesis, diagnostic approaches and treatment tactics using the method of content analysis, analyticalб comparative and contrastive methods. Clinical case: The described clinical case is a variant of the course of syringomyelia, associated with the spinal cord tumor, namely, in particular, anaplastic ependymoma. For a long time, the process remained undetected, despite the long-term examination and drainage of the syringomyelic cavity. Analyzing this case, it is highly important to pay attention to careful history collection, examination of the patient, analysis of the occurrence of certain disorders in order to conduct the neuroimaging examinations in time. Conclusions: Favorable outcome of the disease is directly related to the diagnosis at early stages, especially in young people, the clinical variant of the process, progression of the course, the degree of involvement of various parts of the nervous system and extraneural formations, the severity of the lesion. The treatment tactics and the ability to restore the functions will depend on all these factors.
Drug reprofiling history and potential therapies against Parkinson’s disease
(2022-10-26) Latif, Komal; Ullah, Aman; Shkodina, Anastasiia D.; Boiko, Dmytro I.; Rafique, Zakia; Alghamdi, Badrah S.; Alfaleh, Mohamed A.; Ashraf, Ghulam Md.; Шкодіна, Анастасія Дмитрівна; Бойко, Дмитро Іванович
Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old” drugs to treat typical and uncommon illnesses is progressively becoming an appealing proposition. Drug repurposing is the way toward utilizing existing medications in treating diseases other than the purposes they were initially designed for. Faced with scientific and economic challenges, the prospect of discovering new medication indications is enticing to the pharmaceutical sector. Medication repurposing can be used at various stages of drug development, although it has shown to be most promising when the drug has previously been tested for safety. We describe strategies of drug repurposing for Parkinson’s disease, which is a neurodegenerative condition that primarily affects dopaminergic neurons in the substantia nigra. We also discuss the obstacles faced by the repurposing community and suggest new approaches to solve these challenges so that medicine repurposing can reach its full potential.
Dynamics cognitive functions recovery in the acute period of different subtypes of ischemic stroke after systemic thrombolytic therapy
(Полтавський державний медичний університет, м.Полтава, Україна, 2023) Havlovska, Ya. Yu.; Lytvynenko, N. V.; Shkodina, A. D.; Havlovskyi, O. L.; Гавловська, Ярослава Юріївна; Литвиненко, Наталія Володимирівна; Шкодіна, Анастасія Дмитрівна; Гавловський, Олександр Леонідович
Stroke is the second leading cause of death worldwide, the leading cause of disability, and a significant financial burden. Currently, 3 to 4% of the total health care costs of countries are spent on stroke treatment. Studies of stroke survivors have shown that approximately 10% may develop dementia within the first year after a stroke. However, today the issue of early recovery of patients with acute cerebrovascular diseases and the phenomenology of the development of complications, in particular cognitive disorders in the acute period, is an acute issue, which would allow optimizing personalized strategies for the treatment of such patients. The goal is to evaluate the dynamic changes in the cognitive sphere in patients in the acute II period with atherothrombotic and cardioembolic subtypes after thrombolysis. We conducted a prospective two-center study of patients in the acute phase of ischemic stroke. 89 patients were included in the study: group 1aA (n=32) – patients with atherothrombotic subtype of ischemic stroke (IS), who were subject to thrombolytic therapy (sTLT); group 1aK (n=16) – patients with cardioembolic subtype IS who were to undergo sTLT; group 2 (n=20) –healthy patients with no history of acute cerebrovascular disorders (control group). Assessment of cognitive functions was carried out using international standardized scales, in particular: Mini Mental State Examination (MMSE). We established statistically significant differences between the examined groups for 1 day according to indicators of time orientation (р=0.007), attention and calculation (р<0.001), perception and memory (р=0.001) and the total MMSE score (р<0.001). Statistically significant differences were found between the examined groups on the 14th day in the indicators of attention and calculation (p<0.001) and in the total MMSE score (p<0.001). No significant differences in ∆MMSE were found between groups 1aA and 1aK (р=0.701). In patients with cardioembolic subtype IS, the presence of positive dynamics in the acute period was established, while in patients with atherothrombotic subtype it was not detected. Along with this, the difference in recovery of various domains of the cognitive sphere in the acute period according to subtype IS was noted. This is how we discovered. that the dynamic changes of cognitive functions in the acute IS period after sTLT vary depending on the clinical subtype.

Переглянути

Перегляд Кафедра нервових хвороб за Назва

Результатів на сторінці

Налаштування сортування