Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population
dc.contributor.author | Izmailova, Olga | |
dc.contributor.author | Shlykova, Oksana | |
dc.contributor.author | Kabaliei, Alina | |
dc.contributor.author | Vatsenko, Anastasia | |
dc.contributor.author | Ivashchenko, Dmytro | |
dc.contributor.author | Dudchenko, Maksym | |
dc.contributor.author | Volianskyi, Andrii | |
dc.contributor.author | Zelinskyy, Gennadiy | |
dc.contributor.author | Koval, Tetiana | |
dc.contributor.author | Dittmer, Ulf | |
dc.contributor.author | Kaidashev, Igor | |
dc.contributor.author | Ізмайлова, Ольга Віталіївна | |
dc.contributor.author | Дудченко, Максим Олександрович | |
dc.contributor.author | Іващенко, Дмитро Миколайович | |
dc.contributor.author | Кабалєй, Аліна Вікторівна | |
dc.contributor.author | Волянський, Андрій Юрійович | |
dc.contributor.author | Дітмер, Ульф | |
dc.contributor.author | Зелінський, Геннадій | |
dc.contributor.author | Шликова, Оксана Анатоліївна | |
dc.contributor.author | Ваценко, Анастасія Ігорівна | |
dc.contributor.author | Коваль, Тетяна Ігорівна | |
dc.contributor.author | Кайдашев, Ігор Петрович | |
dc.date.accessioned | 2023-02-20T08:41:36Z | |
dc.date.available | 2023-02-20T08:41:36Z | |
dc.date.issued | 2023-02-13 | |
dc.description.abstract | Gene polymorphism, coding the host proteases, which are involved in the virus entry into the cells can influence the susceptibility to and mortality from coronavirus disease 19 (COVID-19). Angiotensin-converting enzyme 2 (ACE2), transmembrane serine 2 and serine 11A proteases (TMPRSS2, TMPRSS11A), and a cell surface cluster of differentiation 147 (CD147) might be a gene candidate that ex-erts such influence. The aim of this study was to investigate the associations between ace2, tmprss2, tmprss11a, and cd147 polymorphic variants and the severity of COVID-19 in the Ukrainian population. Methods: The study population consisted of the Ukrainian population with COVID-19: patients without oxygen therapy (n=62), with non-invasive (n=92) and invasive (n=35) oxygen therapy, as well as control subjects (n=92). Al-lelic polymorphisms of ace2 rs4240157, tmprss2 rs12329760, and tmprss11a rs353163 were determined by real-time PCR, and cd147 rs8259 polymorphism was detected by PCR with subsequent restrictase analysis. We compared investigated polymorphisms distribution with other populations by meta-analysis. Results: Our study is the first to obtain data about the distribution of investigated gene polymorphisms in the Ukrainian population: tmprss2 rs12329760 – CC 60.9%, CT 35.9%, TT 3.2%; tmprss11a rs353163 – CC 46.7%, CT 40.2%, TT 13.1%; ace2 rs4240157 – CC 7.6%, C 18.5%, CT 22.8%, TT 19.6%, T 31.5%; cd147 rs8259 – TT 60.9%, AT 32.6%, AA 6.5%. This distribution was similar to the Northern, Western and Southern European populations. There was a statistically significant difference in the frequency of tmprss2 polymorphic geno-types CC 57.1%, CT 28.6%, and TT 14.3% (P<0.05) in COVID-19 patients with invasive oxygen therapy in comparison with non-invasive oxygen therapy. This tmprss2 mutation occurs in the scavenger receptor cysteine-rich (SRCR) domain and might be important for protein-protein interaction in a calcium-depend-ent manner. Conclusions: Our study indicated the presence of an association between the tmprss2 rs12329760 polymorphism and the severity of COVID-19 in the Ukrainian population. | uk_UA |
dc.identifier.citation | Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population / O. Izmailova, O. Shlykova, A. Kabaliei [et al.] // Acta Biomed. – 2023. – Vol. 94, №. 1 – e2023030. doi: 10.23750/abm.v94i1.13543. | uk_UA |
dc.identifier.doi | 10.23750/abm.v94i1.13543 | |
dc.identifier.uri | https://repository.pdmu.edu.ua/handle/123456789/20108 | |
dc.language.iso | en | uk_UA |
dc.publisher | Acta Biomed | uk_UA |
dc.subject | transmembrane serine proteases | uk_UA |
dc.subject | TMPRSS2 | uk_UA |
dc.subject | TMPRSS11A | uk_UA |
dc.subject | CD147 | uk_UA |
dc.subject | angiotensin-converting enzyme 2 | uk_UA |
dc.subject | polymorphism | uk_UA |
dc.subject | COVID-19 | uk_UA |
dc.subject | oxygen therapy | uk_UA |
dc.title | Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population | uk_UA |
dc.type | Article | uk_UA |
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