Separate component forms of right ventricular diastolic dysfunction in patients with chronic obstructive pulmonary disease in the conditions of comorbidity with systemic arterial hypertension

Abstract

Among the most common diseases that have a combined course with chronic obstructive pulmonary disease (COPD) are diseases of the cardiovascular system, and the dominant among them is systemic arterial hypertension. The presence of systemic arterial hypertension (AH) increases the existing risk of developing cardiovascular events in patients with COPD and is directly dependent on the level of systolic blood pressure. In addition, it is the cause of an increase in pulmonary vascular resistance and, subsequently, changes in the function of the right ventricle (RV), which can be considered as an additional factor in the development of RV dysfunction in the conditions of a combination of COPD and AH and which has a negative prognostic value. Among a large number of biological processes that are common in the pathogenesis of both COPD and systemic hypertension, endothelial dysfunction draws attention and, as emphasized, its damage is a factor contributing to the development of diastolic dysfunction.