Expression of periferal core molecular clock genes in oral mucosa depends on the chronotype in patients with maxillofacial cellulitis
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Дата
2023-09
Назва журналу
Номер ISSN
Назва тому
Видавець
Journal of Oral Biology and Craniofacial Research
Анотація
Introduction: Accurate determination of the patient’s chronotype is one of the problems of personalized medicine.
Recent studies have shown that determining of the expression of timing genes is a valuable method that can help
gain molecular insight into a patient’s intrinsic circadian timing. Odontogenic cellulitis is very common pathology. Since acute inflammatory diseases are an urgent pathology, the time of surgical intervention can
correspond depend on the time of the patient’s hospitalization.
Materials and methods: The level of mRNA expression of peripheral circadian clock genes clock and bmal1, per1,
cry1 in buccal epithelial cells in patients with odontogenic purulent inflammatory diseases of maxillofacial area
in the morning and evening was investigated.
Опис
Ключові слова
chronotype, oral mucosa, core clock gene expression, cellulitis, odontogenic infection of soft tissues
Бібліографічний опис
Expression of periferal core molecular clock genes in oral mucosa depends on the chronotype in patients with maxillofacial cellulitis / K. Lokes, V. Lychman, O. Izmailova, O. Shlykova, D. Avetikov, I. Kaidashev // Journal of Oral Biology and Craniofacial Research. – 2023. – Vol. 13, issue 5. – P. 517–521.