Quercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of Salmonella typhi

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dc.contributor.authorYelinska, A. M.
dc.contributor.authorLiashenko, L. I.
dc.contributor.authorKostenko, V. O.
dc.contributor.authorЄлінська, Аліна Миколаївна
dc.contributor.authorЛяшенко, Лілія Іванівна
dc.contributor.authorКостенко, Віталій Олександрович
dc.date.accessioned2021-03-26T07:10:31Z
dc.date.available2021-03-26T07:10:31Z
dc.date.issued2019
dc.description.abstractThere has been demonstrated that pharmaceutical effect of epigallocatechin-3-gallate (EGCG), a polyphenol, which is found in green tea (Camellia sinensis), is implemented through the activation of Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2).The importance of Keap1 / Nrf2 / antioxidant response element (ARE) system is determined by the fact that the state of NF-κB- and АР-1-associated pathways depends on its activity. Recent studies have demonstrated the property of quercetin to suppress ubiquitin-dependent proteolysis of complex of NF-κB and its inhibitory protein IκB. All this provides preconditions to eliminate the potentiality of NF-κB-dependent expression of the number of genes of pro-oxidant and pro-inflammatory proteins. However, co-effect produced by quercetin and EGCG on the oxidative nitrosative stress markers in the periodontal tissues is still unclear.uk_UA
dc.identifier.citationYelins’ka A. M. Quercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of Salmonella typhi / A. M. Yelins’ka, L. I. Liashenko, V. O. Kostenko // Wiadomości Lekarskie. – 2019. – T. LXXII, № 8. – P. 1499–1503.uk_UA
dc.identifier.issn0043-5147
dc.identifier.urihttps://repository.pdmu.edu.ua/handle/123456789/15313
dc.language.isoenuk_UA
dc.publisherWydawnictwo Alunauk_UA
dc.subjectsignal pathway Keap1 / Nrf2 / AREuk_UA
dc.subjectperiodontiumuk_UA
dc.subjectepigallocatechin-3-gallateuk_UA
dc.subjectquercetinuk_UA
dc.subjectlipopolysaccharide-induced systemic inflammatory responseuk_UA
dc.subjectoxidative-nitrosative stressuk_UA
dc.titleQuercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of Salmonella typhiuk_UA
dc.typeArticleuk_UA

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