Application efficiency of bifidobacterium bifidum 1 and lactobacillus reuteri dsm 17938 cell-free extracts in vivo
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Дата
2020
Назва журналу
Номер ISSN
Назва тому
Видавець
Анотація
Insufficient efficiency and safety of cellular probiotics encourages the search
for new effective means of correction of microecological disorders. Most of the
beneficial effects of probiotics are due to the biological activity of their
structural components and metabolites. Recently, great hope is pinned on
postbiotic products as a means of restoring the balance of intestinal microbial
populations. The data obtained in this experimental study demonstrate the
ability of cell-free extracts from Bifidobacterium bifidum 1 and Lactobacillus
reuteri DSM 17938 cultures, cultivated in their own disintegrates supplemented
with ascorbic acid, to provide anti-infection protection and correct
microecological disturbances at modeling an infectious process against a
background of antibiotic-induced dysbiosis in mice. The beneficial effects of
cell-free extracts showed up in the acceleration of the pathogen elimination and
an increase in the number of representatives of the positive intestinal
microbiota. The results of the study justify the need for further clinical trials to
determine the therapeutic efficacy of cell-free extracts when included in the
protocols of dysbiosis treatment.
Опис
Ключові слова
probiotic cell-free extracts,, Bifidobacterium bifidum 1, Lactobacillus reuteri DSM 17938, antibiotic-induced dysbiosis, murine model of intestinal staphylococcal infection
Бібліографічний опис
Knysh O. Application efficiency of BifIdobacterium BifIdum 1 and Lactobacillus reuteri DSM 17938 cell-free extracts in vivo / O. Knysh, M. Pogorila, V. Polianska, S. Zachepylo // Science Review. – 2020. – № 5 (32). – P. 9–15.