Shaienko, Z. O.Bobyreva, L. Ye.Шаєнко, Златослава ОлексіївнаБобирьова, Людмила Єгорівна2018-10-102018-10-102018Shaienko Z. O. Combination of Metformin and Pioglitazone and its Effect in Treatment of Comorbid Pathology / Z. O. Shaienko, L. Ye. Bobyreva // Wiadomości Lekarskie. – 2018. – № 2, P. ІІ. – P. 278–280.https://repository.pdmu.edu.ua/handle/123456789/8733Introduction: The early development and high incidence of cardiovascular lesion in patients with type 2 diabetes mellitus is one of the most serious challenges for the diabetology worldwide. Aim: The purpose of the paper is to determine the dynamics of the insulin resistance indices in patients with type 2 diabetes mellitus concomitant with coronary heart disease in the combination therapy with metformin and pioglitazone during 3 and 6 months. Materials and Methods: 95 patients with type 2 diabetes mellitus and coronary heart disease have been treated and randomized into two groups: the comparison group (n=37), treated with metformin and sulfonylureas, and the study group (n=58), treated with metformin in combination with pioglitazone. Prior, after 3 and 6 months of treatment C-peptide was assessed and index of the insulin resistance was calculated. Results: The resulting data proved the statistically significant lowering of the markers and level of the insulin resistance under the effect of combination treatment with metformin and pioglitazone. Conclusions: The proposed variant of the combination therapy has a positive effect on the clinical course of the coronary heart disease in patients with type 2 diabetes mellitus, well tolerated by the patients and can be considered as the pathogenetic factor in the treatment of these diseases.endiabetes mellituscoronary heart diseaseinsulin resistanceArticle