Yelinska, A. M.Liashenko, L. I.Kostenko, V. O.Єлінська, Аліна МиколаївнаЛяшенко, Лілія ІванівнаКостенко, Віталій Олександрович2021-03-262021-03-262019Yelins’ka A. M. Quercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of Salmonella typhi / A. M. Yelins’ka, L. I. Liashenko, V. O. Kostenko // Wiadomości Lekarskie. – 2019. – T. LXXII, № 8. – P. 1499–1503.0043-5147https://repository.pdmu.edu.ua/handle/123456789/15313There has been demonstrated that pharmaceutical effect of epigallocatechin-3-gallate (EGCG), a polyphenol, which is found in green tea (Camellia sinensis), is implemented through the activation of Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2).The importance of Keap1 / Nrf2 / antioxidant response element (ARE) system is determined by the fact that the state of NF-κB- and АР-1-associated pathways depends on its activity. Recent studies have demonstrated the property of quercetin to suppress ubiquitin-dependent proteolysis of complex of NF-κB and its inhibitory protein IκB. All this provides preconditions to eliminate the potentiality of NF-κB-dependent expression of the number of genes of pro-oxidant and pro-inflammatory proteins. However, co-effect produced by quercetin and EGCG on the oxidative nitrosative stress markers in the periodontal tissues is still unclear.ensignal pathway Keap1 / Nrf2 / AREperiodontiumepigallocatechin-3-gallatequercetinlipopolysaccharide-induced systemic inflammatory responseoxidative-nitrosative stressArticle