Vasko, M. Yu.Tkachenko, I. M.Vodoriz, Ya. Yu.Dvornyk, A. V.Pysarenko, Oleh A.Васько, Марина ЮріївнаТкаченко, Ірина МихайлівнаВодоріз, Ярослав ЮрійовичДворник, Анна ВалентинівнаПисаренко, Олег Анатолійович2024-09-252024-09-252024-07Index assessment of periodontal status in patients on the background of administering a drug with circadian activity / M. Y. Vasko, I. M. Tkachenko, Y. Y. Vodoriz [et al.] // Wiadomosci Lekarskie. – 2024. – Vol. 77, issue 7. – P. 1325–1330.PMID: 39241129https://repository.pdmu.edu.ua/handle/123456789/24804Objective: Aim: The aim of this study was to determine the effect of application of drug with circadian activity (pioglitazone) for treatment of patients with periodontist. Patients and methods: Materials and Methods: Group I - 18 individuals with healthy periodontium. Group II - 12 participants with stage II, grade B periodontitis treated with a standard treatment protocol. Group III - 12 participants with stage II, grade B periodontitis, treated with a regimen that included the standard protocol along with the administration of pioglitazone prescribed at recommended times of intake. Group IV - 12 participants with stage II, grade B periodontitis treated with the standard protocol and pioglitazone against the recommended intake hours. Results: Results: The Simplified Oral Hygiene Index in Group I was 0.406±0.034. In Group II, it was 2.5±0.06. In Group III, the hygiene index was 2.633±0.056 and in Group IV it was 2.5±0.059. The Papillary-Marginal-Alveolar Index in Group I was 0.033±0.004. In Group II, it was 0.366±0.011. For Group III, the PMA index was 0.38±0.012 and for Group IV it was 0.378±0.01. The Russell's Periodontal Index in Group I was 0.111±0.008. In Group II, it was 4.668±0.155. For Group III - 4.708±0.132 and for Group IV it was 4.575±0.089. The Gingival Bleeding Index (GBI) in Group I was 0.031±0.003, while in Group II, it was 0.266±0.009, in Group III, it was 0.273±0.007 and in Group IV it was 0.278±0.006. Conclusion: Conclusions: The administration of pioglitazone (the drug with circadian activity) according to its circadian stage indeed has a positive effect on the periodontal status changes of patients with stage II, grade B periodontitis.encircadian rhythmchronotypeperiodontitispioglitazoneArticle10.36740/WLek202407104