Hasiuk, Petro A.Ramus, MykhailoVorobets, AnnaTkachenko, IrynaDzetsiukh, TetianaKalashnikov, DmytroRosolovska, SvitlanaГасюк, Петро АнатолійовичРамусь, Михайло ОлександровичКалашніков, Дмитро ВікторовичТкаченко, Ірина Михайлівна2021-11-262021-11-262021-09Comparative evaluation of histotoxicity indicators of metal alloys for the manufacture of metal ceramic dental constructions / P. A. Hasiuk, М. Ramus, A.Vorobets [et al.] // Wiadomości Lekarskie. – 2021. – Vol. LXXIV, issue 9, p. 1. – P. 2100–2104.https://repository.pdmu.edu.ua/handle/123456789/17161The aim: To carry out a comparative assessment of metal alloys for the manufacture of metal-ceramic constructions of dentures by determining the indicator of their histotoxicity. Materials and methods: To identify the effect of metal alloys on cobalt and nickel bases on the tissue of organism, we carried out an experimental-morphological study of standard samples of metal alloys “Shot-alloy”, “Remanium-2000”, “Cerium”, “Dent-NCB”, “Cellite-N”. Results: A careful histological analysis of the capsules formed around the metal alloy samples during two periods of the experiment showed that the healing time of the subcutaneous tissue was not the same. The most complete healing, that is, the formation of mature fibrous connective tissue, occurred during the implantation of the cobalt based alloy “Remanium-2000” and the capsule formed at the end of the experiment around the implanted sample from the “Shot-alloy” alloy, and during the implantation of the “Cerium” alloy, healing the wound surface and the formation of a connective tissue capsule occurs fully than in previous cases. Conclusions: The analysis of the performed experiment testifies in favor of the point of view that the speed and quality of healing of damaged subcutaneous tissue upon the introduction of implanted research alloys depend largely on the individual chemical components that make up the alloys, or on their combination.enmetal alloysmetal-ceramic constructionshistotoxic researchtissue culture methodArticle10.36740/WLek202109113