Kaidashev, I. P.Izmaylova, O. V.Shlykova, O. A.DuBuske, L. M.Кайдашев, Ігор ПетровичІзмайлова, Ольга ВіталіївнаШликова, Оксана Анатоліївна2022-05-272022-05-272010Comparison of the Prevalence of Polymorphisms of TLR4 Asp299Gly in Patients with Bacterial Sexually Transmitted Diseases Versus the General Population in Ukraine / I. P. Kaidashev, O. V. Izmaylova, O. A. Shlykova, L. M. DuBuske // European academy of allergy and clinical immunology : abstracts of 29 th Ellaci Congress, London, 5 th-9th june 2010. – London, 2010. – P. 1297.https://repository.pdmu.edu.ua/handle/123456789/18433Background: Mutations in genes that encode Toll Like Receptors (TLRs) have been associated with increased or decreased susceptibility to various infectious diseases. ’ This study assesses the prevalence of TLR4 Asp299Gly polymorphism in the Poltava, i I Ukraine general population and in patients with common urogenital infections. Methods: T1_R4 Asp299Gly gene polymorphisms were determined by polymerase chain reaction (PCR) using specific primers followed by oligonucleotide restriction i analysis. 299 healthy inhabitants of Poltava region of Ukraine and 156 patients with urogenital infections including Chlamydiosis (n=16). Ureaplasmosis (n=102). Mycoplasmosis (n=4). Gardnerellosis (n=9). Trichomoniasis (n=2). and having multiple urogenital infections (n^23) all diagnosed by PCR. were assessed for TLR4 gene polymorphisms.enThesis